Effect of NSAIDs on Na⁺/H⁺ exchanger activity in rat colonic crypts

Nonsteroidal anti-inflammatory drugs (NSAIDs; 1) are widely recommended for several acute and chronic conditions. For example, both indomethacin and aspirin are taken for pain relief. Aspirin is also used for prevention of myocardial infarction, and indomethacin can be administered orally or as a su...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2013-09, Vol.305 (5), p.C512-C518
Hauptverfasser:	Roginiel, Aliya C, Kohut, Daniel L, Kaur, Sumanpreet, Saleh, Ahmad M A, Weber, Theresa, Geibel, Peter, Singh, Harmeet, Geibel, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - analogs & derivatives Amiloride - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin - pharmacology Colon - drug effects Colon - metabolism Epithelial Sodium Channel Blockers - pharmacology Gastroenterology Gene Expression Regulation - drug effects Guanidines - pharmacology Humans Hydrogen-Ion Concentration Indomethacin - pharmacology Ion Transport - drug effects Male Nonsteroidal anti-inflammatory drugs Protons Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Rheumatoid arthritis Rodents Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - agonists Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - metabolism
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