TNF-α–mediated bronchial barrier disruption and regulation by src-family kinase activation

Background Because TNF-α is increased in severe asthma, we hypothesized that TNF-α contributes to barrier dysfunction and cell activation in bronchial epithelial cells. We further hypothesized that src-family kinase inhibition would improve barrier function in healthy cells in the presence of TNF-α...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-09, Vol.132 (3), p.665-675.e8
Hauptverfasser:	Hardyman, Michelle A., PhD, Wilkinson, Emily, BSc, Martin, Emma, BMedSci, Jayasekera, Nivenka P., MD, Blume, Cornelia, PhD, Swindle, Emily J., PhD, Gozzard, Neil, PhD, Holgate, Stephen T., MD, DSc, Howarth, Peter H., MD, DM, Davies, Donna E., PhD, Collins, Jane E., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions - drug effects Adherens Junctions - metabolism Airway Allergy and Immunology Asthma - metabolism barrier Biological and medical sciences Bronchi - cytology Bronchi - metabolism bronchial Cadherins - metabolism Catenins - metabolism Cells, Cultured cytokines Cytokines - metabolism Delta Catenin epithelial Epithelial Cells - drug effects Epithelial Cells - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunopathology Indoles - pharmacology Medical sciences proMMP-9 Protein Kinase Inhibitors - pharmacology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis src kinase src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism SU6656 Sulfonamides - pharmacology Tight Junctions - drug effects Tight Junctions - metabolism TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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