Enantioselective binding of chiral 1,14-dimethyl[5]helicene–spermine ligands with B- and Z-DNA

Duplex DNA adopts a right-handed B-DNA conformation under physiological conditions. Z-DNA, meanwhile, has a left-handed helical structure and is in equilibrium with right-handed B-DNA. We recently reported that the bisnaphthyl maleimide–spermine conjugate (1) induced a B- to Z-DNA transition with hi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-10, Vol.21 (19), p.6063-6068
Hauptverfasser:	Tsuji, Genichiro, Kawakami, Kyoko, Sasaki, Shigeki
Format:	Artikel
Sprache:	eng
Schlagworte:	B-DNA Chiral recognition Chromatography, High Pressure Liquid DNA binding ligand DNA, B-Form - chemistry DNA, Z-Form - chemistry electrostatic interactions Helicene Hydrogen-Ion Concentration Isothermal titration calorimetry Ligands Models, Molecular salt concentration spermine Spermine - chemistry Static Electricity Stereoisomerism Surface plasmon resonance Thermodynamics Z-DNA
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