Four-week toxicity study of phenyl isothiocyanate in rats
In a subacute toxicity study, phenyl isothiocyanate (PIT) was administered to male rats on 5 days/wk by gastric intubation at dose levels of 0, 2.5, 10 and 40 mg/kg body weight/day for 4 wk. Body-weight gain was recorded weekly and a complete haematological examination and determinations of alanine...
Gespeichert in:
| Veröffentlicht in: | Food and chemical toxicology 1985-11, Vol.23 (11), p.1015-1017 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1017 |
|---|---|
| container_issue | 11 |
| container_start_page | 1015 |
| container_title | Food and chemical toxicology |
| container_volume | 23 |
| creator | Speijers, G.J.A. Danse, L.H.J.C. van Leeuwen, F.X.R. Loeber, J.G. |
| description | In a subacute toxicity study, phenyl isothiocyanate (PIT) was administered to male rats on 5 days/wk by gastric intubation at dose levels of 0, 2.5, 10 and 40 mg/kg body weight/day for 4 wk. Body-weight gain was recorded weekly and a complete haematological examination and determinations of alanine aminotransferase, aspartate aminotransferase and thyroxine in serum were performed. The heart, liver, spleen, kidneys, thyroid, adrenals and mesenteric lymph nodes were weighed and examined microscopically. In the highest dose group, slightly decreased growth and a statistically significant increase in mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were noted. Relative heart, liver, kidney and adrenal weights also showed a statistically significant increase in the highest dose group. Total serum thyroxine and free thyroxine were decreased in the groups given 10 or 40 mg PIT/kg. Microscopic examinations revealed no abnormalities. The measurement of the serum thyroxine concentration appeared to be the most sensitive indicator of an effect in this experiment. |
| doi_str_mv | 10.1016/0278-6915(85)90253-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_14295875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0278691585902534</els_id><sourcerecordid>14295875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-9b92ce15bcfa78d9db8cbb4a248e667b273ccec374c684a23caf1b3a6f562f383</originalsourceid><addsrcrecordid>eNqFkE1rFEEQhhtR4ib6DxTmIKKHif39cREkGBMIeInnpqemhrTOTq_dPer8e2ezyx71VFD1vC_FQ8grRi8ZZfoD5ca22jH1zqr3jnIlWvmEbJg1otVCsadkc0Kek_NSvlNKDTP6jJxJarTjbkPcdZpz-xvxR1PTnwixLk2pc780aWh2DzgtYxNLqg8xwRKmULGJU5NDLS_IsyGMBV8e5wX5dv35_uqmvfv65fbq010LQrPaus5xQKY6GIKxves7C10nA5cWtTYdNwIAQRgJ2q5rAWFgnQh6UJoPwooL8vbQu8vp54yl-m0sgOMYJkxz8Uxyp6xRKygPIORUSsbB73Lchrx4Rv3emN_r8Hsd3ir_aMzLNfb62D93W-xPoaOi9f7meA8FwjjkMEEsJ8xqJZ3l_8WkoFqKFft4wHBV9iti9gUiToB9zAjV9yn--92_5xaUIw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14295875</pqid></control><display><type>article</type><title>Four-week toxicity study of phenyl isothiocyanate in rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Speijers, G.J.A. ; Danse, L.H.J.C. ; van Leeuwen, F.X.R. ; Loeber, J.G.</creator><creatorcontrib>Speijers, G.J.A. ; Danse, L.H.J.C. ; van Leeuwen, F.X.R. ; Loeber, J.G.</creatorcontrib><description>In a subacute toxicity study, phenyl isothiocyanate (PIT) was administered to male rats on 5 days/wk by gastric intubation at dose levels of 0, 2.5, 10 and 40 mg/kg body weight/day for 4 wk. Body-weight gain was recorded weekly and a complete haematological examination and determinations of alanine aminotransferase, aspartate aminotransferase and thyroxine in serum were performed. The heart, liver, spleen, kidneys, thyroid, adrenals and mesenteric lymph nodes were weighed and examined microscopically. In the highest dose group, slightly decreased growth and a statistically significant increase in mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were noted. Relative heart, liver, kidney and adrenal weights also showed a statistically significant increase in the highest dose group. Total serum thyroxine and free thyroxine were decreased in the groups given 10 or 40 mg PIT/kg. Microscopic examinations revealed no abnormalities. The measurement of the serum thyroxine concentration appeared to be the most sensitive indicator of an effect in this experiment.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/0278-6915(85)90253-4</identifier><identifier>PMID: 4076929</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - drug effects ; Fat industries ; Food industries ; Food toxicology ; Fundamental and applied biological sciences. Psychology ; Isothiocyanates ; Male ; Medical sciences ; Organ Size - drug effects ; Rats ; Rats, Inbred Strains ; Thiocyanates - toxicity ; Thyroid Gland - drug effects ; Thyroxine - blood ; Toxicology</subject><ispartof>Food and chemical toxicology, 1985-11, Vol.23 (11), p.1015-1017</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-9b92ce15bcfa78d9db8cbb4a248e667b273ccec374c684a23caf1b3a6f562f383</citedby><cites>FETCH-LOGICAL-c361t-9b92ce15bcfa78d9db8cbb4a248e667b273ccec374c684a23caf1b3a6f562f383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0278-6915(85)90253-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8430643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8654982$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4076929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Speijers, G.J.A.</creatorcontrib><creatorcontrib>Danse, L.H.J.C.</creatorcontrib><creatorcontrib>van Leeuwen, F.X.R.</creatorcontrib><creatorcontrib>Loeber, J.G.</creatorcontrib><title>Four-week toxicity study of phenyl isothiocyanate in rats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>In a subacute toxicity study, phenyl isothiocyanate (PIT) was administered to male rats on 5 days/wk by gastric intubation at dose levels of 0, 2.5, 10 and 40 mg/kg body weight/day for 4 wk. Body-weight gain was recorded weekly and a complete haematological examination and determinations of alanine aminotransferase, aspartate aminotransferase and thyroxine in serum were performed. The heart, liver, spleen, kidneys, thyroid, adrenals and mesenteric lymph nodes were weighed and examined microscopically. In the highest dose group, slightly decreased growth and a statistically significant increase in mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were noted. Relative heart, liver, kidney and adrenal weights also showed a statistically significant increase in the highest dose group. Total serum thyroxine and free thyroxine were decreased in the groups given 10 or 40 mg PIT/kg. Microscopic examinations revealed no abnormalities. The measurement of the serum thyroxine concentration appeared to be the most sensitive indicator of an effect in this experiment.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Fat industries</subject><subject>Food industries</subject><subject>Food toxicology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isothiocyanates</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Thiocyanates - toxicity</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroxine - blood</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFEEQhhtR4ib6DxTmIKKHif39cREkGBMIeInnpqemhrTOTq_dPer8e2ezyx71VFD1vC_FQ8grRi8ZZfoD5ca22jH1zqr3jnIlWvmEbJg1otVCsadkc0Kek_NSvlNKDTP6jJxJarTjbkPcdZpz-xvxR1PTnwixLk2pc780aWh2DzgtYxNLqg8xwRKmULGJU5NDLS_IsyGMBV8e5wX5dv35_uqmvfv65fbq010LQrPaus5xQKY6GIKxves7C10nA5cWtTYdNwIAQRgJ2q5rAWFgnQh6UJoPwooL8vbQu8vp54yl-m0sgOMYJkxz8Uxyp6xRKygPIORUSsbB73Lchrx4Rv3emN_r8Hsd3ir_aMzLNfb62D93W-xPoaOi9f7meA8FwjjkMEEsJ8xqJZ3l_8WkoFqKFft4wHBV9iti9gUiToB9zAjV9yn--92_5xaUIw</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>Speijers, G.J.A.</creator><creator>Danse, L.H.J.C.</creator><creator>van Leeuwen, F.X.R.</creator><creator>Loeber, J.G.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198511</creationdate><title>Four-week toxicity study of phenyl isothiocyanate in rats</title><author>Speijers, G.J.A. ; Danse, L.H.J.C. ; van Leeuwen, F.X.R. ; Loeber, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-9b92ce15bcfa78d9db8cbb4a248e667b273ccec374c684a23caf1b3a6f562f383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Fat industries</topic><topic>Food industries</topic><topic>Food toxicology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Isothiocyanates</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Thiocyanates - toxicity</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroxine - blood</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Speijers, G.J.A.</creatorcontrib><creatorcontrib>Danse, L.H.J.C.</creatorcontrib><creatorcontrib>van Leeuwen, F.X.R.</creatorcontrib><creatorcontrib>Loeber, J.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Speijers, G.J.A.</au><au>Danse, L.H.J.C.</au><au>van Leeuwen, F.X.R.</au><au>Loeber, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Four-week toxicity study of phenyl isothiocyanate in rats</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>1985-11</date><risdate>1985</risdate><volume>23</volume><issue>11</issue><spage>1015</spage><epage>1017</epage><pages>1015-1017</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>In a subacute toxicity study, phenyl isothiocyanate (PIT) was administered to male rats on 5 days/wk by gastric intubation at dose levels of 0, 2.5, 10 and 40 mg/kg body weight/day for 4 wk. Body-weight gain was recorded weekly and a complete haematological examination and determinations of alanine aminotransferase, aspartate aminotransferase and thyroxine in serum were performed. The heart, liver, spleen, kidneys, thyroid, adrenals and mesenteric lymph nodes were weighed and examined microscopically. In the highest dose group, slightly decreased growth and a statistically significant increase in mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were noted. Relative heart, liver, kidney and adrenal weights also showed a statistically significant increase in the highest dose group. Total serum thyroxine and free thyroxine were decreased in the groups given 10 or 40 mg PIT/kg. Microscopic examinations revealed no abnormalities. The measurement of the serum thyroxine concentration appeared to be the most sensitive indicator of an effect in this experiment.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>4076929</pmid><doi>10.1016/0278-6915(85)90253-4</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 1985-11, Vol.23 (11), p.1015-1017 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14295875 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Body Weight - drug effects Fat industries Food industries Food toxicology Fundamental and applied biological sciences. Psychology Isothiocyanates Male Medical sciences Organ Size - drug effects Rats Rats, Inbred Strains Thiocyanates - toxicity Thyroid Gland - drug effects Thyroxine - blood Toxicology |
| title | Four-week toxicity study of phenyl isothiocyanate in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T07%3A56%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Four-week%20toxicity%20study%20of%20phenyl%20isothiocyanate%20in%20rats&rft.jtitle=Food%20and%20chemical%20toxicology&rft.au=Speijers,%20G.J.A.&rft.date=1985-11&rft.volume=23&rft.issue=11&rft.spage=1015&rft.epage=1017&rft.pages=1015-1017&rft.issn=0278-6915&rft.eissn=1873-6351&rft.coden=FCTOD7&rft_id=info:doi/10.1016/0278-6915(85)90253-4&rft_dat=%3Cproquest_cross%3E14295875%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14295875&rft_id=info:pmid/4076929&rft_els_id=0278691585902534&rfr_iscdi=true |