Mechanisms of Altered Ca2+ Handling in Heart Failure

Mechanisms of Altered Ca2+ Handling in Heart Failure

Ca plays a crucial role in connecting membrane excitability with contraction in myocardium. The hallmark features of heart failure are mechanical dysfunction and arrhythmias; defective intracellular Ca homeostasis is a central cause of contractile dysfunction and arrhythmias in failing myocardium. D...

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Veröffentlicht in:Circulation research 2013-08, Vol.113 (6), p.690-708
Hauptverfasser: Luo, Min, Anderson, Mark E.
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Sprache:eng
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Animals
Calcium - metabolism
Excitation Contraction Coupling
Heart Failure - metabolism
Humans
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Anderson, Mark E.
description Ca plays a crucial role in connecting membrane excitability with contraction in myocardium. The hallmark features of heart failure are mechanical dysfunction and arrhythmias; defective intracellular Ca homeostasis is a central cause of contractile dysfunction and arrhythmias in failing myocardium. Defective Ca homeostasis in heart failure can result from pathological alteration in the expression and activity of an increasingly understood collection of Ca homeostatic and structural proteins, ion channels, and enzymes. This review focuses on the molecular mechanisms of defective Ca cycling in heart failure and considers how fundamental understanding of these pathways may translate into novel and innovative therapies.
doi_str_mv 10.1161/CIRCRESAHA.113.301651
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source Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Animals
Calcium - metabolism
Excitation Contraction Coupling
Heart Failure - metabolism
Humans
title Mechanisms of Altered Ca2+ Handling in Heart Failure
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