X-ray crystallographic evidence for the presence of the cysteine tryptophylquinone cofactor in L-lysine ε-oxidase from Marinomonas mediterranea

We have determined the x-ray crystal structure of L-lysine ε-oxidase from Marinomonas mediterranea in its native and L-lysine-complex forms at 1.94- and 1.99-Å resolution, respectively. In the native enzyme, electron densities clearly indicate the presence of cysteine tryptophylquinone (CTQ) previou...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2013-09, Vol.154 (3), p.233-236
Hauptverfasser:	Okazaki, Seiji, Nakano, Shogo, Matsui, Daisuke, Akaji, Shusaku, Inagaki, Kenji, Asano, Yasuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - chemistry Bacterial Proteins - chemistry Catalytic Domain Coenzymes - chemistry Crystallography, X-Ray Dipeptides - chemistry Electrons Indolequinones - chemistry Kinetics Marinomonas - chemistry Marinomonas - enzymology Models, Molecular Schiff Bases - chemistry
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