Flavoring Extracts of Hemidesmus indicus Roots and Vanilla planifolia Pods Exhibit In vitro Acetylcholinesterase Inhibitory Activities
Acetylcholinesterase inhibitors (AChEIs) are important for treatment of Alzheimer’s disease and other neurological disorders. Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods,...
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| Veröffentlicht in: | Plant foods for human nutrition (Dordrecht) 2013-09, Vol.68 (3), p.247-253 |
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| creator | Kundu, Anish Mitra, Adinpunya |
| description | Acetylcholinesterase inhibitors (AChEIs) are important for treatment of Alzheimer’s disease and other neurological disorders. Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, as possible sources for AChEI. Root and pod extracts of H. indicus and V. planifolia, respectively, produce fragrant phenolic compounds, 2-hydroxy-4-methoxybenzaldehyde (MBALD) and 4-hydroxy-3-methoxybenzaldehyde (vanillin). These methoxybenzaldehydes were shown to have inhibitory potential against acetylcholinesterase (AChE). Vanillin (IC₅₀ = 0.037 mM) was detected as more efficient inhibitor than MBALD (IC₅₀ = 0.047 mM). This finding was supported by kinetic analysis. Thus, plant-based food flavoring agents showed capacity in curing Alzheimer’s disease and other neurological dysfunctions. |
| doi_str_mv | 10.1007/s11130-013-0363-z |
| format | Article |
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Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, as possible sources for AChEI. Root and pod extracts of H. indicus and V. planifolia, respectively, produce fragrant phenolic compounds, 2-hydroxy-4-methoxybenzaldehyde (MBALD) and 4-hydroxy-3-methoxybenzaldehyde (vanillin). These methoxybenzaldehydes were shown to have inhibitory potential against acetylcholinesterase (AChE). Vanillin (IC₅₀ = 0.037 mM) was detected as more efficient inhibitor than MBALD (IC₅₀ = 0.047 mM). This finding was supported by kinetic analysis. Thus, plant-based food flavoring agents showed capacity in curing Alzheimer’s disease and other neurological dysfunctions.</description><identifier>ISSN: 0921-9668</identifier><identifier>EISSN: 1573-9104</identifier><identifier>DOI: 10.1007/s11130-013-0363-z</identifier><identifier>PMID: 23715789</identifier><language>eng</language><publisher>Boston: Springer-Verlag</publisher><subject>acetylcholinesterase ; Alzheimer disease ; Alzheimer Disease - drug therapy ; Benzaldehydes - pharmacology ; Biological and medical sciences ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Cholinesterase Inhibitors - pharmacology ; Ecology ; Feeding. Feeding behavior ; Flavoring Agents - chemistry ; flavorings ; Food Additives ; Food Science ; Fundamental and applied biological sciences. Psychology ; Hemidesmus - chemistry ; Hemidesmus indicus ; inhibitory concentration 50 ; Kinetics ; Nervous System Diseases - drug therapy ; Nutrition ; Original Paper ; phenolic compounds ; Phytotherapy ; plant extracts ; Plant Extracts - pharmacology ; Plant Physiology ; Plant Roots - chemistry ; plant-based foods ; pods ; roots ; Seeds - chemistry ; Vanilla - chemistry ; Vanilla planifolia ; vanillin ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Plant foods for human nutrition (Dordrecht), 2013-09, Vol.68 (3), p.247-253</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-c27e128a5e8b2c95df979caaf575690b819461e9333d55afa3ff6299844e18d73</citedby><cites>FETCH-LOGICAL-c464t-c27e128a5e8b2c95df979caaf575690b819461e9333d55afa3ff6299844e18d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11130-013-0363-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11130-013-0363-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27734302$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23715789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kundu, Anish</creatorcontrib><creatorcontrib>Mitra, Adinpunya</creatorcontrib><title>Flavoring Extracts of Hemidesmus indicus Roots and Vanilla planifolia Pods Exhibit In vitro Acetylcholinesterase Inhibitory Activities</title><title>Plant foods for human nutrition (Dordrecht)</title><addtitle>Plant Foods Hum Nutr</addtitle><addtitle>Plant Foods Hum Nutr</addtitle><description>Acetylcholinesterase inhibitors (AChEIs) are important for treatment of Alzheimer’s disease and other neurological disorders. Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, as possible sources for AChEI. Root and pod extracts of H. indicus and V. planifolia, respectively, produce fragrant phenolic compounds, 2-hydroxy-4-methoxybenzaldehyde (MBALD) and 4-hydroxy-3-methoxybenzaldehyde (vanillin). These methoxybenzaldehydes were shown to have inhibitory potential against acetylcholinesterase (AChE). Vanillin (IC₅₀ = 0.037 mM) was detected as more efficient inhibitor than MBALD (IC₅₀ = 0.047 mM). This finding was supported by kinetic analysis. Thus, plant-based food flavoring agents showed capacity in curing Alzheimer’s disease and other neurological dysfunctions.</description><subject>acetylcholinesterase</subject><subject>Alzheimer disease</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Benzaldehydes - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Ecology</subject><subject>Feeding. Feeding behavior</subject><subject>Flavoring Agents - chemistry</subject><subject>flavorings</subject><subject>Food Additives</subject><subject>Food Science</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemidesmus - chemistry</subject><subject>Hemidesmus indicus</subject><subject>inhibitory concentration 50</subject><subject>Kinetics</subject><subject>Nervous System Diseases - drug therapy</subject><subject>Nutrition</subject><subject>Original Paper</subject><subject>phenolic compounds</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Physiology</subject><subject>Plant Roots - chemistry</subject><subject>plant-based foods</subject><subject>pods</subject><subject>roots</subject><subject>Seeds - chemistry</subject><subject>Vanilla - chemistry</subject><subject>Vanilla planifolia</subject><subject>vanillin</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0921-9668</issn><issn>1573-9104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhAdiAN0hsAv6LHS-rqqWVKoGAsrXuOHbrKhMPdlIxfQCemztkgB0L61o63zm2jwl5ydk7zph5XznnkjWMy4ZJLZuHR2TFWyMby5l6TFbMCt5Yrbsj8qzWO4Yerdun5EhIg1xnV-Tn-QD3uaTxhp79mAr4qdIc6UXYpD7UzVxpGvvkcX7OGTUYe_oNxjQMQLcDbmIeEtBPua8YcJvWaaKXI71PU8n0xIdpN_hbRMZQp1CgBlR_U7nsUJ8SkinU5-RJhKGGF4d5TK7Pz76eXjRXHz9cnp5cNV5pNTVemMBFB23o1sLbto_WWA8QW9Nqy9Ydt0rzYKWUfdtCBBmjFtZ2SgXe9UYek7dL7rbk7zPeyW1S9QFfM4Y8V8eV6IxRkmtE-YL6kmstIbptSRsoO8eZ29fvlvod1u_29bsH9Lw6xM_rTej_Ov70jcCbAwDVwxALjD7Vf5wxUkkmkBMLV7f7vwnF3eW5jFjNf09_vZgiZAc3BYOvvwjGFcMlrZbyF_E8qPs</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Kundu, Anish</creator><creator>Mitra, Adinpunya</creator><general>Springer-Verlag</general><general>Springer US</general><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Flavoring Extracts of Hemidesmus indicus Roots and Vanilla planifolia Pods Exhibit In vitro Acetylcholinesterase Inhibitory Activities</title><author>Kundu, Anish ; Mitra, Adinpunya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-c27e128a5e8b2c95df979caaf575690b819461e9333d55afa3ff6299844e18d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acetylcholinesterase</topic><topic>Alzheimer disease</topic><topic>Alzheimer Disease - drug therapy</topic><topic>Benzaldehydes - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Ecology</topic><topic>Feeding. Feeding behavior</topic><topic>Flavoring Agents - chemistry</topic><topic>flavorings</topic><topic>Food Additives</topic><topic>Food Science</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemidesmus - chemistry</topic><topic>Hemidesmus indicus</topic><topic>inhibitory concentration 50</topic><topic>Kinetics</topic><topic>Nervous System Diseases - drug therapy</topic><topic>Nutrition</topic><topic>Original Paper</topic><topic>phenolic compounds</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Physiology</topic><topic>Plant Roots - chemistry</topic><topic>plant-based foods</topic><topic>pods</topic><topic>roots</topic><topic>Seeds - chemistry</topic><topic>Vanilla - chemistry</topic><topic>Vanilla planifolia</topic><topic>vanillin</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kundu, Anish</creatorcontrib><creatorcontrib>Mitra, Adinpunya</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kundu, Anish</au><au>Mitra, Adinpunya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flavoring Extracts of Hemidesmus indicus Roots and Vanilla planifolia Pods Exhibit In vitro Acetylcholinesterase Inhibitory Activities</atitle><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle><stitle>Plant Foods Hum Nutr</stitle><addtitle>Plant Foods Hum Nutr</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>68</volume><issue>3</issue><spage>247</spage><epage>253</epage><pages>247-253</pages><issn>0921-9668</issn><eissn>1573-9104</eissn><abstract>Acetylcholinesterase inhibitors (AChEIs) are important for treatment of Alzheimer’s disease and other neurological disorders. Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, as possible sources for AChEI. Root and pod extracts of H. indicus and V. planifolia, respectively, produce fragrant phenolic compounds, 2-hydroxy-4-methoxybenzaldehyde (MBALD) and 4-hydroxy-3-methoxybenzaldehyde (vanillin). These methoxybenzaldehydes were shown to have inhibitory potential against acetylcholinesterase (AChE). Vanillin (IC₅₀ = 0.037 mM) was detected as more efficient inhibitor than MBALD (IC₅₀ = 0.047 mM). This finding was supported by kinetic analysis. Thus, plant-based food flavoring agents showed capacity in curing Alzheimer’s disease and other neurological dysfunctions.</abstract><cop>Boston</cop><pub>Springer-Verlag</pub><pmid>23715789</pmid><doi>10.1007/s11130-013-0363-z</doi><tpages>7</tpages></addata></record> |
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| subjects | acetylcholinesterase Alzheimer disease Alzheimer Disease - drug therapy Benzaldehydes - pharmacology Biological and medical sciences Chemistry Chemistry and Materials Science Chemistry/Food Science Cholinesterase Inhibitors - pharmacology Ecology Feeding. Feeding behavior Flavoring Agents - chemistry flavorings Food Additives Food Science Fundamental and applied biological sciences. Psychology Hemidesmus - chemistry Hemidesmus indicus inhibitory concentration 50 Kinetics Nervous System Diseases - drug therapy Nutrition Original Paper phenolic compounds Phytotherapy plant extracts Plant Extracts - pharmacology Plant Physiology Plant Roots - chemistry plant-based foods pods roots Seeds - chemistry Vanilla - chemistry Vanilla planifolia vanillin Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Flavoring Extracts of Hemidesmus indicus Roots and Vanilla planifolia Pods Exhibit In vitro Acetylcholinesterase Inhibitory Activities |
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