Near-unity nuclear polarization with an open-source ¹²⁹Xe hyperpolarizer for NMR and MRI

The exquisite NMR spectral sensitivity and negligible reactivity of hyperpolarized xenon-129 (HP ¹²⁹Xe) make it attractive for a number of magnetic resonance applications; moreover, HP ¹²⁹Xe embodies an alternative to rare and nonrenewable ³He. However, the ability to reliably and inexpensively prod...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2013-08, Vol.110 (35), p.14150-14155
Hauptverfasser: Nikolaou, Panayiotis, Coffey, Aaron M., Walkup, Laura L., Gust, Brogan M., Whiting, Nicholas, Newton, Hayley, Barcus, Scott, Muradyan, Iga, Dabaghyan, Mikayel, Moroz, Gregory D., Rosen, Matthew S., Patz, Samuel, Barlow, Michael J., Chekmenev, Eduard Y., Goodson, Boyd M.
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container_issue 35
container_start_page 14150
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 110
creator Nikolaou, Panayiotis
Coffey, Aaron M.
Walkup, Laura L.
Gust, Brogan M.
Whiting, Nicholas
Newton, Hayley
Barcus, Scott
Muradyan, Iga
Dabaghyan, Mikayel
Moroz, Gregory D.
Rosen, Matthew S.
Patz, Samuel
Barlow, Michael J.
Chekmenev, Eduard Y.
Goodson, Boyd M.
description The exquisite NMR spectral sensitivity and negligible reactivity of hyperpolarized xenon-129 (HP ¹²⁹Xe) make it attractive for a number of magnetic resonance applications; moreover, HP ¹²⁹Xe embodies an alternative to rare and nonrenewable ³He. However, the ability to reliably and inexpensively produce large quantities of HP ¹²⁹Xe with sufficiently high ¹²⁹Xe nuclear spin polarization (P Xₑ) remains a significant challenge—particularly at high Xe densities. We present results from our “open-source” large-scale (∼1 L/h) ¹²⁹Xe polarizer for clinical, preclinical, and materials NMR and MRI research. Automated and composed mostly of off-the-shelf components, this “hyperpolarizer” is designed to be readily implementable in other laboratories. The device runs with high resonant photon flux (up to 200 W at the Rb D ₁ line) in the xenon-rich regime (up to 1,800 torr Xe in 500 cc) in either single-batch or stopped-flow mode, negating in part the usual requirement of Xe cryocollection. Excellent agreement is observed among four independent methods used to measure spin polarization. In-cell P Xₑ values of ∼90%, ∼57%, ∼50%, and ∼30% have been measured for Xe loadings of ∼300, ∼500, ∼760, and ∼1,570 torr, respectively. P Xₑ values of ∼41% and ∼28% (with ∼760 and ∼1,545 torr Xe loadings) have been measured after transfer to Tedlar bags and transport to a clinical 3 T scanner for MR imaging, including demonstration of lung MRI with a healthy human subject. Long “in-bag” ¹²⁹Xe polarization decay times have been measured (T ₁ ∼38 min and ∼5.9 h at ∼1.5 mT and 3 T, respectively)—more than sufficient for a variety of applications.
doi_str_mv 10.1073/pnas.1306586110
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subjects Gas spectroscopy
Humans
Imaging
Lasers
Lung - pathology
Lungs
Magnetic fields
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Nuclear magnetic resonance
Optical pumping
Physical Sciences
Polarized light
Research universities
Xenon
Xenon Isotopes - chemistry
title Near-unity nuclear polarization with an open-source ¹²⁹Xe hyperpolarizer for NMR and MRI
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