Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

Members of the cytochromes P450 superfamily (P450s) catalyze a huge variety of oxidation reactions in microbes and higher organisms. Most P450 families are highly divergent, but in contrast the cytochrome P450 14α-sterol demethylase (CYP51) family is one of the most ancient and conserved, catalyzing...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-08, Vol.110 (35), p.E3360-E3367
Hauptverfasser:	Geisler, Katrin, Hughes, Richard K, Sainsbury, Frank, Lomonossoff, George P, Rejzek, Martin, Fairhurst, Shirley, Olsen, Carl-Erik, Motawia, Mohammed Saddik, Melton, Rachel E, Hemmings, Andrew M, Bak, Søren, Osbourn, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Amino Acid Sequence animals anti-infective agents Anti-Infective Agents - metabolism antifungal properties Avena - metabolism Bioassays Biological Sciences catalytic activity cytochrome P-450 epoxides Flowers & plants fungi genes hydroxylation Intramolecular Transferases - metabolism Metabolism Models, Molecular molecular models Molecular Sequence Data mutants Mutation Nicotiana - enzymology oats oxidation PNAS Plus Sequence Homology, Amino Acid Sterol 14-Demethylase - chemistry Sterol 14-Demethylase - genetics Sterol 14-Demethylase - metabolism Triterpenes - metabolism triterpenoids
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