Antitumor activity of Pulsatilla koreana extract in anaplastic thyroid cancer via apoptosis and anti-angiogenesis

Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. However, the effect of PK...

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Veröffentlicht in:	Molecular medicine reports 2013-01, Vol.7 (1), p.26-30
Hauptverfasser:	PARK, BYUNG HEE, JUNG, KYUNG HEE, SON, MI KWON, SEO, JU HYEON, LEE, HEE-SEUNG, LEE, JU-HEE, HONG, SOON-SUN
Format:	Artikel
Sprache:	eng
Schlagworte:	anaplastic thyroid cancer Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents, Phytogenic - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Cancer therapies Caspase Caspase-3 Cell Line, Tumor Cell Proliferation - drug effects Disease Models, Animal DNA fragmentation DNA nucleotidylexotransferase Dysentery Endothelial cells Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hypoxia-inducible factors Immunoglobulins Inflammation Male Metastasis Mice Neovascularization, Pathologic - drug therapy Plant Extracts - pharmacology Poly(ADP-ribose) polymerase Pulsatilla - chemistry Pulsatilla koreana extract Rodents Studies Thyroid cancer Thyroid Carcinoma, Anaplastic Thyroid Neoplasms - drug therapy Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Tumor Burden - drug effects Tumors Umbilical vein Vascular endothelial growth factor Xenograft Model Antitumor Assays Xenografts
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