Recombinant human histidine triad nucleotide-binding protein 1 attenuates liver fibrosis induced by carbon tetrachloride in rats

It is currently thought that the transforming growth factor-β (TGF-β)/Smad signaling pathway acts as a central pathway leading to liver fibrosis, and that the aberrant Wnt/β-catenin signaling pathway also plays a vital role in the development of liver fibrosis. There is evidence that the histidine t...

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Veröffentlicht in:	Molecular medicine reports 2013-10, Vol.8 (4), p.1023-1028
Hauptverfasser:	WU, FEI, HUANG, SHAOFANG, ZHU, NANLAN, LIU, WEI, ZHANG, YANAN, HE, YONGWEN
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Alcohol Animals Bile Carbon Tetrachloride Cell cycle Collagen Cyclin D1 Fibrosis Gene expression Genetic engineering Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Histidine histidine triad nucleotide-binding protein 1 Humans Hydroxyproline Hydroxyproline - metabolism Laboratory animals Liver Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis - chemically induced Liver Cirrhosis - drug therapy liver fibrosis Male Nerve Tissue Proteins - pharmacology Nerve Tissue Proteins - therapeutic use Pathogenesis Proteins Rats Rats, Sprague-Dawley recombinant protein Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Rodents Signal transduction Smad protein Smad3 protein Smad3 Protein - genetics Smad3 Protein - metabolism Smad7 protein Smad7 Protein - genetics Smad7 Protein - metabolism Smooth muscle Studies transforming growing factor-β Transforming growth factor Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming growth factor-b Transforming growth factor-b1 Wnt protein β-Catenin
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