Use of global assays to understand clinical phenotype in congenital factor VII deficiency

Summary Congenital factor VII (FVII) deficiency is characterized by genotypic variability and phenotypic heterogeneity. Traditional screening and factor assays are unable to reliably predict clinical bleeding phenotype and guide haemorrhage prevention strategy. Global assays of coagulation and fibri...

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Veröffentlicht in:	Haemophilia : the official journal of the World Federation of Hemophilia 2013-09, Vol.19 (5), p.765-772
Hauptverfasser:	Greene, L. A., Goldenberg, N. A., Simpson, M. L., Villalobos-Menuey, E., Bombardier, C., Acharya, S. S., Santiago-Borrero, P. J., Cambara, A., DiMichele, D. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Child Child, Preschool clot formation Cross-Sectional Studies factor VII deficiency Factor VII Deficiency - blood Factor VII Deficiency - diagnosis Factor VII Deficiency - genetics Female Fibrinolysis global assay Hemorrhage - blood Hemorrhage - diagnosis Hemorrhage - etiology Hemorrhage - genetics Humans Male Phenotype plasmin generation Prospective Studies thrombin generation Young Adult
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