Preparation of rat brain membranes highly enriched with opiate kappa binding sites using site-directed acylating agents: Optimization of assay conditions

The goal of this study was to determine optimal conditions with which to measure opiate kappa binding sites in rat brain. Membranes were pretreated with mu-selective (BIT) and delta-selective (FIT) site-directed acylating agents (Rice et al., Science 220, 314–316), and the binding of [ 3H]bremazocin...

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Veröffentlicht in:	Neuropeptides (Edinburgh) 1985-12, Vol.6 (6), p.503-516
Hauptverfasser:	Rothman, Richard B., Bykov, Victor, Danks, Janine A., Jacobson, Arthur E., Burke, Terrence R., Rice, Kenner C., Herkenham, Miles
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Animals Autoradiography Benzomorphans - metabolism Benzomorphans - pharmacology brain Brain - metabolism Enkephalin, Leucine - analogs & derivatives Enkephalin, Leucine - metabolism Enkephalin, Leucine-2-Alanine In Vitro Techniques Membranes - metabolism opiates Rats Receptors, Opioid - metabolism Receptors, Opioid, kappa Sodium Chloride - pharmacology
Online-Zugang:	Volltext
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