Combined screening for open spina bifida at 11-13 weeks using fetal biparietal diameter and maternal serum markers

Objective Screening at 11-13 weeks with ultrasound biparietal diameter (BPD) can detect half of open spina bifida cases. Maternal serum α-fetoprotein (AFP) levels at 15-19 weeks are increased 3- to 4-fold, in open spina bifida. We assessed whether combined screening using BPD, AFP, and other serum m...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2013-09, Vol.209 (3), p.223.e1-223.e5
Hauptverfasser:	Bernard, Jean-Pierre, MD, Cuckle, Howard S., MSC, DPhil, Bernard, Maguy A., MD, PhD, Brochet, Christine, MD, Salomon, Laurent J., MD, PhD, Ville, Yves, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha-Fetoproteins - analysis Biomarkers - blood Chorionic Gonadotropin, beta Subunit, Human - blood False Positive Reactions Female fetus first trimester Humans neural tube defects Obstetrics and Gynecology Pregnancy Pregnancy-Associated Plasma Protein-A - analysis Spina Bifida Cystica - diagnosis Spina Bifida Cystica - diagnostic imaging Ultrasonography, Prenatal ultrasound
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