A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn
Polygonum chinense Linn., a folk medicine, has long been used for the treatment of diarrhea and enteritis in southwestern China. However, the components responsible for its anti-diarrheal activity are still poorly understood. To determine anti-diarrheal activities of Polygonum chinense L. and to ide...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 2013-09, Vol.149 (2), p.499-505 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 505 |
|---|---|
| container_issue | 2 |
| container_start_page | 499 |
| container_title | Journal of ethnopharmacology |
| container_volume | 149 |
| creator | Xiao, Hai-Tao Tsang, Siu-Wai Qin, Hong-Yan Choi, Franky F.K. Yang, Zhi-Jun Han, Quan-Bin Chen, Hu-Biao Xu, Hong-Xi Shen, Hong Lu, Ai-Ping Bian, Zhao-Xiang |
| description | Polygonum chinense Linn., a folk medicine, has long been used for the treatment of diarrhea and enteritis in southwestern China. However, the components responsible for its anti-diarrheal activity are still poorly understood.
To determine anti-diarrheal activities of Polygonum chinense L. and to identify its active components through bioactivity-guided isolation technique.
Animals were orally administered with the extract of Polygonum chinense L. The anti-diarrheal effects of 75% ethanol extract, four fractions with different polarities from 75% ethanol extract, different eluates collected from Diaion HP-20 macroporous resin chromatography, ellagic acid and corilagin, were examined based on mouse models of castor oil- and magnesium sulfate-induced diarrhea.
The results showed that the 75% ethanol extract of Polygonum chinense L. exhibited significant anti-diarrheal activities in a dose-dependent manner in two mouse models. Through in vivo bioactivity-guided fractionation processes, n-butanol and aqueous fractions were found to exhibit prominent anti-diarrheal activities, and two major compounds, ellagic acid and corilagin, from these active fractions were found to possess anti-diarrheal effects.
Present study provides evidence of the utilization of Polygonum chinense L. for diarrhea, and ellagic acid and corilagin are two components contributing to the anti-diarrheal effect.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2013.07.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1428515335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874113004960</els_id><sourcerecordid>1428515335</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-9cdbc57baa314686e8c86e5ff3eee51fd84e1bc10490200d89631aeb3b4768613</originalsourceid><addsrcrecordid>eNp90E1v3CAQgGFUtWq2SX9ALy3HXuwwBhusnqIo_ZBWaqUkZ4RhvMvKC1uwI-2_D6tNeuyFuTwzQi8hn4DVwKC73tU7PNQNA14zWTMm35AVKNlUspX8LVkxLlWlpIAL8iHnHSsCBHtPLhqu-rYHuSIPN3Tw0djZP_n5WG0W79DRPC_uSGOg8xapCbOvnDcpbdFM9NXSONI_cTpuYlj21G59wJCRrn0IV-TdaKaMH1_mJXn8fvdw-7Na__7x6_ZmXVku5Vz11g22lYMxHESnOlS2PO04ckRsYXRKIAwWmOhZw5hTfcfB4MAHIQsHfkm-nu8eUvy7YJ713meL02QCxiVrEI1qoeW8LRTO1KaYc8JRH5Lfm3TUwPQppt7pElOfYmomdUlVdj6_nF-GPbp_G6_1CvhyBqOJ2mySz_rxvlwQpbRQbXcS384CS4Ynj0ln6zFYdD6hnbWL_j8feAaF745e</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1428515335</pqid></control><display><type>article</type><title>A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Xiao, Hai-Tao ; Tsang, Siu-Wai ; Qin, Hong-Yan ; Choi, Franky F.K. ; Yang, Zhi-Jun ; Han, Quan-Bin ; Chen, Hu-Biao ; Xu, Hong-Xi ; Shen, Hong ; Lu, Ai-Ping ; Bian, Zhao-Xiang</creator><creatorcontrib>Xiao, Hai-Tao ; Tsang, Siu-Wai ; Qin, Hong-Yan ; Choi, Franky F.K. ; Yang, Zhi-Jun ; Han, Quan-Bin ; Chen, Hu-Biao ; Xu, Hong-Xi ; Shen, Hong ; Lu, Ai-Ping ; Bian, Zhao-Xiang</creatorcontrib><description>Polygonum chinense Linn., a folk medicine, has long been used for the treatment of diarrhea and enteritis in southwestern China. However, the components responsible for its anti-diarrheal activity are still poorly understood.
To determine anti-diarrheal activities of Polygonum chinense L. and to identify its active components through bioactivity-guided isolation technique.
Animals were orally administered with the extract of Polygonum chinense L. The anti-diarrheal effects of 75% ethanol extract, four fractions with different polarities from 75% ethanol extract, different eluates collected from Diaion HP-20 macroporous resin chromatography, ellagic acid and corilagin, were examined based on mouse models of castor oil- and magnesium sulfate-induced diarrhea.
The results showed that the 75% ethanol extract of Polygonum chinense L. exhibited significant anti-diarrheal activities in a dose-dependent manner in two mouse models. Through in vivo bioactivity-guided fractionation processes, n-butanol and aqueous fractions were found to exhibit prominent anti-diarrheal activities, and two major compounds, ellagic acid and corilagin, from these active fractions were found to possess anti-diarrheal effects.
Present study provides evidence of the utilization of Polygonum chinense L. for diarrhea, and ellagic acid and corilagin are two components contributing to the anti-diarrheal effect.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2013.07.007</identifier><identifier>PMID: 23895917</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>animal models ; Animals ; Anti-diarrheal activity ; antidiarrheal effect ; Antidiarrheals - therapeutic use ; Castor Oil ; Chemical Fractionation ; chromatography ; Corilagin ; diarrhea ; Diarrhea - drug therapy ; Ellagic acid ; Ellagic Acid - therapeutic use ; enteritis ; ethanol ; fractionation ; Glucosides - therapeutic use ; Hydrolyzable Tannins ; isolation techniques ; magnesium ; Magnesium Sulfate ; Mice ; Mice, Inbred ICR ; oral administration ; Phytotherapy ; Plant Components, Aerial ; Plant Extracts - therapeutic use ; Polygonum ; Polygonum chinense Linn ; Solvents - chemistry ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 2013-09, Vol.149 (2), p.499-505</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-9cdbc57baa314686e8c86e5ff3eee51fd84e1bc10490200d89631aeb3b4768613</citedby><cites>FETCH-LOGICAL-c377t-9cdbc57baa314686e8c86e5ff3eee51fd84e1bc10490200d89631aeb3b4768613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2013.07.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23895917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Hai-Tao</creatorcontrib><creatorcontrib>Tsang, Siu-Wai</creatorcontrib><creatorcontrib>Qin, Hong-Yan</creatorcontrib><creatorcontrib>Choi, Franky F.K.</creatorcontrib><creatorcontrib>Yang, Zhi-Jun</creatorcontrib><creatorcontrib>Han, Quan-Bin</creatorcontrib><creatorcontrib>Chen, Hu-Biao</creatorcontrib><creatorcontrib>Xu, Hong-Xi</creatorcontrib><creatorcontrib>Shen, Hong</creatorcontrib><creatorcontrib>Lu, Ai-Ping</creatorcontrib><creatorcontrib>Bian, Zhao-Xiang</creatorcontrib><title>A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Polygonum chinense Linn., a folk medicine, has long been used for the treatment of diarrhea and enteritis in southwestern China. However, the components responsible for its anti-diarrheal activity are still poorly understood.
To determine anti-diarrheal activities of Polygonum chinense L. and to identify its active components through bioactivity-guided isolation technique.
Animals were orally administered with the extract of Polygonum chinense L. The anti-diarrheal effects of 75% ethanol extract, four fractions with different polarities from 75% ethanol extract, different eluates collected from Diaion HP-20 macroporous resin chromatography, ellagic acid and corilagin, were examined based on mouse models of castor oil- and magnesium sulfate-induced diarrhea.
The results showed that the 75% ethanol extract of Polygonum chinense L. exhibited significant anti-diarrheal activities in a dose-dependent manner in two mouse models. Through in vivo bioactivity-guided fractionation processes, n-butanol and aqueous fractions were found to exhibit prominent anti-diarrheal activities, and two major compounds, ellagic acid and corilagin, from these active fractions were found to possess anti-diarrheal effects.
Present study provides evidence of the utilization of Polygonum chinense L. for diarrhea, and ellagic acid and corilagin are two components contributing to the anti-diarrheal effect.
[Display omitted]</description><subject>animal models</subject><subject>Animals</subject><subject>Anti-diarrheal activity</subject><subject>antidiarrheal effect</subject><subject>Antidiarrheals - therapeutic use</subject><subject>Castor Oil</subject><subject>Chemical Fractionation</subject><subject>chromatography</subject><subject>Corilagin</subject><subject>diarrhea</subject><subject>Diarrhea - drug therapy</subject><subject>Ellagic acid</subject><subject>Ellagic Acid - therapeutic use</subject><subject>enteritis</subject><subject>ethanol</subject><subject>fractionation</subject><subject>Glucosides - therapeutic use</subject><subject>Hydrolyzable Tannins</subject><subject>isolation techniques</subject><subject>magnesium</subject><subject>Magnesium Sulfate</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>oral administration</subject><subject>Phytotherapy</subject><subject>Plant Components, Aerial</subject><subject>Plant Extracts - therapeutic use</subject><subject>Polygonum</subject><subject>Polygonum chinense Linn</subject><subject>Solvents - chemistry</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1v3CAQgGFUtWq2SX9ALy3HXuwwBhusnqIo_ZBWaqUkZ4RhvMvKC1uwI-2_D6tNeuyFuTwzQi8hn4DVwKC73tU7PNQNA14zWTMm35AVKNlUspX8LVkxLlWlpIAL8iHnHSsCBHtPLhqu-rYHuSIPN3Tw0djZP_n5WG0W79DRPC_uSGOg8xapCbOvnDcpbdFM9NXSONI_cTpuYlj21G59wJCRrn0IV-TdaKaMH1_mJXn8fvdw-7Na__7x6_ZmXVku5Vz11g22lYMxHESnOlS2PO04ckRsYXRKIAwWmOhZw5hTfcfB4MAHIQsHfkm-nu8eUvy7YJ713meL02QCxiVrEI1qoeW8LRTO1KaYc8JRH5Lfm3TUwPQppt7pElOfYmomdUlVdj6_nF-GPbp_G6_1CvhyBqOJ2mySz_rxvlwQpbRQbXcS384CS4Ynj0ln6zFYdD6hnbWL_j8feAaF745e</recordid><startdate>20130916</startdate><enddate>20130916</enddate><creator>Xiao, Hai-Tao</creator><creator>Tsang, Siu-Wai</creator><creator>Qin, Hong-Yan</creator><creator>Choi, Franky F.K.</creator><creator>Yang, Zhi-Jun</creator><creator>Han, Quan-Bin</creator><creator>Chen, Hu-Biao</creator><creator>Xu, Hong-Xi</creator><creator>Shen, Hong</creator><creator>Lu, Ai-Ping</creator><creator>Bian, Zhao-Xiang</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130916</creationdate><title>A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn</title><author>Xiao, Hai-Tao ; Tsang, Siu-Wai ; Qin, Hong-Yan ; Choi, Franky F.K. ; Yang, Zhi-Jun ; Han, Quan-Bin ; Chen, Hu-Biao ; Xu, Hong-Xi ; Shen, Hong ; Lu, Ai-Ping ; Bian, Zhao-Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-9cdbc57baa314686e8c86e5ff3eee51fd84e1bc10490200d89631aeb3b4768613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Anti-diarrheal activity</topic><topic>antidiarrheal effect</topic><topic>Antidiarrheals - therapeutic use</topic><topic>Castor Oil</topic><topic>Chemical Fractionation</topic><topic>chromatography</topic><topic>Corilagin</topic><topic>diarrhea</topic><topic>Diarrhea - drug therapy</topic><topic>Ellagic acid</topic><topic>Ellagic Acid - therapeutic use</topic><topic>enteritis</topic><topic>ethanol</topic><topic>fractionation</topic><topic>Glucosides - therapeutic use</topic><topic>Hydrolyzable Tannins</topic><topic>isolation techniques</topic><topic>magnesium</topic><topic>Magnesium Sulfate</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>oral administration</topic><topic>Phytotherapy</topic><topic>Plant Components, Aerial</topic><topic>Plant Extracts - therapeutic use</topic><topic>Polygonum</topic><topic>Polygonum chinense Linn</topic><topic>Solvents - chemistry</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Hai-Tao</creatorcontrib><creatorcontrib>Tsang, Siu-Wai</creatorcontrib><creatorcontrib>Qin, Hong-Yan</creatorcontrib><creatorcontrib>Choi, Franky F.K.</creatorcontrib><creatorcontrib>Yang, Zhi-Jun</creatorcontrib><creatorcontrib>Han, Quan-Bin</creatorcontrib><creatorcontrib>Chen, Hu-Biao</creatorcontrib><creatorcontrib>Xu, Hong-Xi</creatorcontrib><creatorcontrib>Shen, Hong</creatorcontrib><creatorcontrib>Lu, Ai-Ping</creatorcontrib><creatorcontrib>Bian, Zhao-Xiang</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Hai-Tao</au><au>Tsang, Siu-Wai</au><au>Qin, Hong-Yan</au><au>Choi, Franky F.K.</au><au>Yang, Zhi-Jun</au><au>Han, Quan-Bin</au><au>Chen, Hu-Biao</au><au>Xu, Hong-Xi</au><au>Shen, Hong</au><au>Lu, Ai-Ping</au><au>Bian, Zhao-Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2013-09-16</date><risdate>2013</risdate><volume>149</volume><issue>2</issue><spage>499</spage><epage>505</epage><pages>499-505</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Polygonum chinense Linn., a folk medicine, has long been used for the treatment of diarrhea and enteritis in southwestern China. However, the components responsible for its anti-diarrheal activity are still poorly understood.
To determine anti-diarrheal activities of Polygonum chinense L. and to identify its active components through bioactivity-guided isolation technique.
Animals were orally administered with the extract of Polygonum chinense L. The anti-diarrheal effects of 75% ethanol extract, four fractions with different polarities from 75% ethanol extract, different eluates collected from Diaion HP-20 macroporous resin chromatography, ellagic acid and corilagin, were examined based on mouse models of castor oil- and magnesium sulfate-induced diarrhea.
The results showed that the 75% ethanol extract of Polygonum chinense L. exhibited significant anti-diarrheal activities in a dose-dependent manner in two mouse models. Through in vivo bioactivity-guided fractionation processes, n-butanol and aqueous fractions were found to exhibit prominent anti-diarrheal activities, and two major compounds, ellagic acid and corilagin, from these active fractions were found to possess anti-diarrheal effects.
Present study provides evidence of the utilization of Polygonum chinense L. for diarrhea, and ellagic acid and corilagin are two components contributing to the anti-diarrheal effect.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23895917</pmid><doi>10.1016/j.jep.2013.07.007</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2013-09, Vol.149 (2), p.499-505 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1428515335 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | animal models Animals Anti-diarrheal activity antidiarrheal effect Antidiarrheals - therapeutic use Castor Oil Chemical Fractionation chromatography Corilagin diarrhea Diarrhea - drug therapy Ellagic acid Ellagic Acid - therapeutic use enteritis ethanol fractionation Glucosides - therapeutic use Hydrolyzable Tannins isolation techniques magnesium Magnesium Sulfate Mice Mice, Inbred ICR oral administration Phytotherapy Plant Components, Aerial Plant Extracts - therapeutic use Polygonum Polygonum chinense Linn Solvents - chemistry traditional medicine |
| title | A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T13%3A13%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20bioactivity-guided%20study%20on%20the%20anti-diarrheal%20activity%20of%20Polygonum%20chinense%20Linn&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Xiao,%20Hai-Tao&rft.date=2013-09-16&rft.volume=149&rft.issue=2&rft.spage=499&rft.epage=505&rft.pages=499-505&rft.issn=0378-8741&rft.eissn=1872-7573&rft_id=info:doi/10.1016/j.jep.2013.07.007&rft_dat=%3Cproquest_cross%3E1428515335%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1428515335&rft_id=info:pmid/23895917&rft_els_id=S0378874113004960&rfr_iscdi=true |