One-Pot Synthesis of Iron Oxide Nanoparticles with Functional Silane Shells: A Versatile General Precursor for Conjugations and Biomedical Applications
Iron oxide nanoparticles (IONPs) and their surface modifications with therapeutic or diagnostic (theranostic, TN) agents are of great interest. Here we present a novel one-pot synthesis of a versatile general TN precursor (aminosilane-coated IONPs [IONP-Sil(NH2)]) with surface amine groups. Surface...
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| Veröffentlicht in: | Langmuir 2013-08, Vol.29 (34), p.10850-10858 |
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| creator | Yathindranath, Vinith Sun, Zhizhi Worden, Matthew Donald, Lynda J Thliveris, James A Miller, Donald W Hegmann, Torsten |
| description | Iron oxide nanoparticles (IONPs) and their surface modifications with therapeutic or diagnostic (theranostic, TN) agents are of great interest. Here we present a novel one-pot synthesis of a versatile general TN precursor (aminosilane-coated IONPs [IONP-Sil(NH2)]) with surface amine groups. Surface functional group conversion to carboxylic acid was accomplished by conjugating poly(ethylene glycol) diacid to IONP-Sil(NH2). The NPs were characterized using powder X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM, selected area electron diffraction (SAED), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared (FT-IR) spectroscopy. Biocompatibility and cell uptake profile of the nanoparticles were evaluated in-vitro using cultured liver cells (HepG2). Oleylamine (hydrophobic) and bovine serum albumin (BSA) as model drugs were attached to IONP-Sil-PEG(COOH). The ability of IONP-Sil(NH2) to bind small interfering RNA (siRNA) is also shown. |
| doi_str_mv | 10.1021/la402007d |
| format | Article |
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Here we present a novel one-pot synthesis of a versatile general TN precursor (aminosilane-coated IONPs [IONP-Sil(NH2)]) with surface amine groups. Surface functional group conversion to carboxylic acid was accomplished by conjugating poly(ethylene glycol) diacid to IONP-Sil(NH2). The NPs were characterized using powder X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM, selected area electron diffraction (SAED), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared (FT-IR) spectroscopy. Biocompatibility and cell uptake profile of the nanoparticles were evaluated in-vitro using cultured liver cells (HepG2). Oleylamine (hydrophobic) and bovine serum albumin (BSA) as model drugs were attached to IONP-Sil-PEG(COOH). 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The ability of IONP-Sil(NH2) to bind small interfering RNA (siRNA) is also shown.</description><subject>Chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Exact sciences and technology</subject><subject>Ferric Compounds - chemistry</subject><subject>General and physical chemistry</subject><subject>Nanoparticles - chemistry</subject><subject>Physical and chemical studies. Granulometry. 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Granulometry. Electrokinetic phenomena</topic><topic>Silanes - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yathindranath, Vinith</creatorcontrib><creatorcontrib>Sun, Zhizhi</creatorcontrib><creatorcontrib>Worden, Matthew</creatorcontrib><creatorcontrib>Donald, Lynda J</creatorcontrib><creatorcontrib>Thliveris, James A</creatorcontrib><creatorcontrib>Miller, Donald W</creatorcontrib><creatorcontrib>Hegmann, Torsten</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yathindranath, Vinith</au><au>Sun, Zhizhi</au><au>Worden, Matthew</au><au>Donald, Lynda J</au><au>Thliveris, James A</au><au>Miller, Donald W</au><au>Hegmann, Torsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-Pot Synthesis of Iron Oxide Nanoparticles with Functional Silane Shells: A Versatile General Precursor for Conjugations and Biomedical Applications</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2013-08-27</date><risdate>2013</risdate><volume>29</volume><issue>34</issue><spage>10850</spage><epage>10858</epage><pages>10850-10858</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><coden>LANGD5</coden><abstract>Iron oxide nanoparticles (IONPs) and their surface modifications with therapeutic or diagnostic (theranostic, TN) agents are of great interest. 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| subjects | Chemistry Colloidal state and disperse state Exact sciences and technology Ferric Compounds - chemistry General and physical chemistry Nanoparticles - chemistry Physical and chemical studies. Granulometry. Electrokinetic phenomena Silanes - chemistry |
| title | One-Pot Synthesis of Iron Oxide Nanoparticles with Functional Silane Shells: A Versatile General Precursor for Conjugations and Biomedical Applications |
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