KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603
The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new Paenibacillus species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated...
Gespeichert in:
| Veröffentlicht in: | Journal of antibiotics 2013-08, Vol.66 (8), p.465-471 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 471 |
|---|---|
| container_issue | 8 |
| container_start_page | 465 |
| container_title | Journal of antibiotics |
| container_volume | 66 |
| creator | Kai, Hirohito Yamashita, Midori Takase, Shigehiro Hashimoto, Michizane Muramatsu, Hideyuki Nakamura, Ikuko Yoshikawa, Koji Ezaki, Masami Nitta, Kumiko Watanabe, Masato Inamura, Noriaki Fujie, Akihiko |
| description | The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new
Paenibacillus
species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C
79
H
115
N
19
O
18
. KB425796-A (1) showed antifungal activities against
Aspergillus fumigatus
and the micafungin-resistant infectious fungi
Trichosporon asahii
,
Rhizopus oryza
e,
Pseudallescheria boydii
and
Cryptococcus neoformans
. |
| doi_str_mv | 10.1038/ja.2013.63 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1428514970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1428514970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-ef71bf72846124047f011a34708313c99b1de02766d60d55befb332d5489f2653</originalsourceid><addsrcrecordid>eNpl0F1LwzAUBuAgipsfN_4ACXgjaus5SZqkl3P4hUO90OuQtuno6NrZtML-vR2dInp1AufhzeEl5AQhROD6emFDBshDyXfIGLXGAIWMd8kYgGGgNYMROfB-AcAVV3qfjBhXSiOqMXl-uhEsUrEMJlfU0qr-dCW1VVvkXTW3wzMp6rZI6aqpsy51GU3W9NW6qkhsWpRl56lfhTTiIIEfkb3clt4db-cheb-7fZs-BLOX-8fpZBakQkAbuFxhkiumhUQmQKgcEC0XCjRHnsZxgpkDpqTMJGRRlLg84ZxlkdBxzmTED8n5kNsf9dE535pl4VNXlrZydecNCqYjFLGCnp79oYu6a6r-OoNKq0jwGFSvLgaVNrX3jcvNqimWtlkbBLNp2Sys2bRsJO_x6TayS5Yu-6HftfbgcgC-X1Vz1_z683_cF2jPgF0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1787543907</pqid></control><display><type>article</type><title>KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Kai, Hirohito ; Yamashita, Midori ; Takase, Shigehiro ; Hashimoto, Michizane ; Muramatsu, Hideyuki ; Nakamura, Ikuko ; Yoshikawa, Koji ; Ezaki, Masami ; Nitta, Kumiko ; Watanabe, Masato ; Inamura, Noriaki ; Fujie, Akihiko</creator><creatorcontrib>Kai, Hirohito ; Yamashita, Midori ; Takase, Shigehiro ; Hashimoto, Michizane ; Muramatsu, Hideyuki ; Nakamura, Ikuko ; Yoshikawa, Koji ; Ezaki, Masami ; Nitta, Kumiko ; Watanabe, Masato ; Inamura, Noriaki ; Fujie, Akihiko</creatorcontrib><description>The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new
Paenibacillus
species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C
79
H
115
N
19
O
18
. KB425796-A (1) showed antifungal activities against
Aspergillus fumigatus
and the micafungin-resistant infectious fungi
Trichosporon asahii
,
Rhizopus oryza
e,
Pseudallescheria boydii
and
Cryptococcus neoformans
.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2013.63</identifier><identifier>PMID: 23778117</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/22/1292 ; Antifungal Agents - chemistry ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Aspergillus fumigatus - drug effects ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Chromatography, High Pressure Liquid - methods ; Cryptococcus neoformans - drug effects ; Depsipeptides - chemistry ; Depsipeptides - isolation & purification ; Depsipeptides - pharmacology ; Drug Resistance, Fungal ; Fermentation ; Freeze Drying ; Life Sciences ; Medicinal Chemistry ; Microbial Sensitivity Tests ; Microbiology ; Organic Chemistry ; original-article ; Paenibacillus - metabolism ; Pseudallescheria - drug effects ; Rhizopus - drug effects ; RNA, Bacterial - genetics ; RNA, Ribosomal, 16S - genetics ; Sequence Analysis, RNA ; Solvent extraction ; Solvents - chemistry ; Trichosporon - drug effects</subject><ispartof>Journal of antibiotics, 2013-08, Vol.66 (8), p.465-471</ispartof><rights>Japan Antibiotics Research Association 2013</rights><rights>Copyright Nature Publishing Group Aug 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-ef71bf72846124047f011a34708313c99b1de02766d60d55befb332d5489f2653</citedby><cites>FETCH-LOGICAL-c440t-ef71bf72846124047f011a34708313c99b1de02766d60d55befb332d5489f2653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23778117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kai, Hirohito</creatorcontrib><creatorcontrib>Yamashita, Midori</creatorcontrib><creatorcontrib>Takase, Shigehiro</creatorcontrib><creatorcontrib>Hashimoto, Michizane</creatorcontrib><creatorcontrib>Muramatsu, Hideyuki</creatorcontrib><creatorcontrib>Nakamura, Ikuko</creatorcontrib><creatorcontrib>Yoshikawa, Koji</creatorcontrib><creatorcontrib>Ezaki, Masami</creatorcontrib><creatorcontrib>Nitta, Kumiko</creatorcontrib><creatorcontrib>Watanabe, Masato</creatorcontrib><creatorcontrib>Inamura, Noriaki</creatorcontrib><creatorcontrib>Fujie, Akihiko</creatorcontrib><title>KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new
Paenibacillus
species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C
79
H
115
N
19
O
18
. KB425796-A (1) showed antifungal activities against
Aspergillus fumigatus
and the micafungin-resistant infectious fungi
Trichosporon asahii
,
Rhizopus oryza
e,
Pseudallescheria boydii
and
Cryptococcus neoformans
.</description><subject>631/326/22/1292</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Aspergillus fumigatus - drug effects</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Cryptococcus neoformans - drug effects</subject><subject>Depsipeptides - chemistry</subject><subject>Depsipeptides - isolation & purification</subject><subject>Depsipeptides - pharmacology</subject><subject>Drug Resistance, Fungal</subject><subject>Fermentation</subject><subject>Freeze Drying</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Paenibacillus - metabolism</subject><subject>Pseudallescheria - drug effects</subject><subject>Rhizopus - drug effects</subject><subject>RNA, Bacterial - genetics</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Sequence Analysis, RNA</subject><subject>Solvent extraction</subject><subject>Solvents - chemistry</subject><subject>Trichosporon - drug effects</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpl0F1LwzAUBuAgipsfN_4ACXgjaus5SZqkl3P4hUO90OuQtuno6NrZtML-vR2dInp1AufhzeEl5AQhROD6emFDBshDyXfIGLXGAIWMd8kYgGGgNYMROfB-AcAVV3qfjBhXSiOqMXl-uhEsUrEMJlfU0qr-dCW1VVvkXTW3wzMp6rZI6aqpsy51GU3W9NW6qkhsWpRl56lfhTTiIIEfkb3clt4db-cheb-7fZs-BLOX-8fpZBakQkAbuFxhkiumhUQmQKgcEC0XCjRHnsZxgpkDpqTMJGRRlLg84ZxlkdBxzmTED8n5kNsf9dE535pl4VNXlrZydecNCqYjFLGCnp79oYu6a6r-OoNKq0jwGFSvLgaVNrX3jcvNqimWtlkbBLNp2Sys2bRsJO_x6TayS5Yu-6HftfbgcgC-X1Vz1_z683_cF2jPgF0</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Kai, Hirohito</creator><creator>Yamashita, Midori</creator><creator>Takase, Shigehiro</creator><creator>Hashimoto, Michizane</creator><creator>Muramatsu, Hideyuki</creator><creator>Nakamura, Ikuko</creator><creator>Yoshikawa, Koji</creator><creator>Ezaki, Masami</creator><creator>Nitta, Kumiko</creator><creator>Watanabe, Masato</creator><creator>Inamura, Noriaki</creator><creator>Fujie, Akihiko</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130801</creationdate><title>KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603</title><author>Kai, Hirohito ; Yamashita, Midori ; Takase, Shigehiro ; Hashimoto, Michizane ; Muramatsu, Hideyuki ; Nakamura, Ikuko ; Yoshikawa, Koji ; Ezaki, Masami ; Nitta, Kumiko ; Watanabe, Masato ; Inamura, Noriaki ; Fujie, Akihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-ef71bf72846124047f011a34708313c99b1de02766d60d55befb332d5489f2653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/326/22/1292</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Aspergillus fumigatus - drug effects</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Cryptococcus neoformans - drug effects</topic><topic>Depsipeptides - chemistry</topic><topic>Depsipeptides - isolation & purification</topic><topic>Depsipeptides - pharmacology</topic><topic>Drug Resistance, Fungal</topic><topic>Fermentation</topic><topic>Freeze Drying</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Paenibacillus - metabolism</topic><topic>Pseudallescheria - drug effects</topic><topic>Rhizopus - drug effects</topic><topic>RNA, Bacterial - genetics</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Sequence Analysis, RNA</topic><topic>Solvent extraction</topic><topic>Solvents - chemistry</topic><topic>Trichosporon - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kai, Hirohito</creatorcontrib><creatorcontrib>Yamashita, Midori</creatorcontrib><creatorcontrib>Takase, Shigehiro</creatorcontrib><creatorcontrib>Hashimoto, Michizane</creatorcontrib><creatorcontrib>Muramatsu, Hideyuki</creatorcontrib><creatorcontrib>Nakamura, Ikuko</creatorcontrib><creatorcontrib>Yoshikawa, Koji</creatorcontrib><creatorcontrib>Ezaki, Masami</creatorcontrib><creatorcontrib>Nitta, Kumiko</creatorcontrib><creatorcontrib>Watanabe, Masato</creatorcontrib><creatorcontrib>Inamura, Noriaki</creatorcontrib><creatorcontrib>Fujie, Akihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kai, Hirohito</au><au>Yamashita, Midori</au><au>Takase, Shigehiro</au><au>Hashimoto, Michizane</au><au>Muramatsu, Hideyuki</au><au>Nakamura, Ikuko</au><au>Yoshikawa, Koji</au><au>Ezaki, Masami</au><au>Nitta, Kumiko</au><au>Watanabe, Masato</au><au>Inamura, Noriaki</au><au>Fujie, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>66</volume><issue>8</issue><spage>465</spage><epage>471</epage><pages>465-471</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new
Paenibacillus
species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C
79
H
115
N
19
O
18
. KB425796-A (1) showed antifungal activities against
Aspergillus fumigatus
and the micafungin-resistant infectious fungi
Trichosporon asahii
,
Rhizopus oryza
e,
Pseudallescheria boydii
and
Cryptococcus neoformans
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23778117</pmid><doi>10.1038/ja.2013.63</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | Journal of antibiotics, 2013-08, Vol.66 (8), p.465-471 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1428514970 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 631/326/22/1292 Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Aspergillus fumigatus - drug effects Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Chromatography, High Pressure Liquid - methods Cryptococcus neoformans - drug effects Depsipeptides - chemistry Depsipeptides - isolation & purification Depsipeptides - pharmacology Drug Resistance, Fungal Fermentation Freeze Drying Life Sciences Medicinal Chemistry Microbial Sensitivity Tests Microbiology Organic Chemistry original-article Paenibacillus - metabolism Pseudallescheria - drug effects Rhizopus - drug effects RNA, Bacterial - genetics RNA, Ribosomal, 16S - genetics Sequence Analysis, RNA Solvent extraction Solvents - chemistry Trichosporon - drug effects |
| title | KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T07%3A47%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=KB425796-A,%20a%20novel%20antifungal%20antibiotic%20produced%20by%20Paenibacillus%20sp.%20530603&rft.jtitle=Journal%20of%20antibiotics&rft.au=Kai,%20Hirohito&rft.date=2013-08-01&rft.volume=66&rft.issue=8&rft.spage=465&rft.epage=471&rft.pages=465-471&rft.issn=0021-8820&rft.eissn=1881-1469&rft_id=info:doi/10.1038/ja.2013.63&rft_dat=%3Cproquest_cross%3E1428514970%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1787543907&rft_id=info:pmid/23778117&rfr_iscdi=true |