Evaluation of ovarian function in 35–40-year-old women with polycystic ovary syndrome
Abstract Objective To assess gonadotrophin secretion, ovarian steroid production and ovarian reserve in PCOS women during the onset of reproductive decline, in order to characterize their ovarian function at this age. Study design Forty PCOS patients and 35 healthy women (35–40 years of age) were in...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2013-09, Vol.170 (1), p.165-170 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | de Guevara, Amanda Ladrón Crisosto, Nicolás Echiburú, Bárbara Preisler, Jessica Vantman, Natalie Bollmann, Josefina Pérez-Bravo, Francisco Sir-Petermann, Teresa |
| description | Abstract Objective To assess gonadotrophin secretion, ovarian steroid production and ovarian reserve in PCOS women during the onset of reproductive decline, in order to characterize their ovarian function at this age. Study design Forty PCOS patients and 35 healthy women (35–40 years of age) were included. Clinical history, anthropometry, transvaginal ultrasound and a leuprolide acetate test (10 μg/kg s.c.) were performed. Gonadotrophins, steroid hormones, SHBG, inhibin B and AMH were determined. Results Basal and peak LH levels were similar in both groups. Basal and peak FSH levels were significantly higher in the control group. Androgens, peak oestradiol, ovarian volume, antral follicle count and AMH levels were significantly higher in PCOS patients. Conclusion These observations suggest that during late reproductive age, gonadotrophin secretion in women with PCOS is clearly different from that observed in control women and may also differ from that of younger PCOS patients. New features like normal LH and lower FSH levels associated with a higher ovarian reserve may give a different reproductive profile to these women. |
| doi_str_mv | 10.1016/j.ejogrb.2013.06.013 |
| format | Article |
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Study design Forty PCOS patients and 35 healthy women (35–40 years of age) were included. Clinical history, anthropometry, transvaginal ultrasound and a leuprolide acetate test (10 μg/kg s.c.) were performed. Gonadotrophins, steroid hormones, SHBG, inhibin B and AMH were determined. Results Basal and peak LH levels were similar in both groups. Basal and peak FSH levels were significantly higher in the control group. Androgens, peak oestradiol, ovarian volume, antral follicle count and AMH levels were significantly higher in PCOS patients. Conclusion These observations suggest that during late reproductive age, gonadotrophin secretion in women with PCOS is clearly different from that observed in control women and may also differ from that of younger PCOS patients. New features like normal LH and lower FSH levels associated with a higher ovarian reserve may give a different reproductive profile to these women.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2013.06.013</identifier><identifier>PMID: 23845170</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Aging - physiology ; Anti-Mullerian Hormone - blood ; Case-Control Studies ; Female ; Follicle Stimulating Hormone - blood ; Gonadal axis ; Humans ; Late reproductive age ; Luteinizing Hormone - blood ; Obstetrics and Gynecology ; Ovarian reserve ; Ovary - cytology ; Ovary - physiopathology ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - physiopathology</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2013-09, Vol.170 (1), p.165-170</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-fd02a615b4c3c7b0162cc9063ccad2bde73f3ec4ff0c6607a8528b6db361598d3</citedby><cites>FETCH-LOGICAL-c417t-fd02a615b4c3c7b0162cc9063ccad2bde73f3ec4ff0c6607a8528b6db361598d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030121151300273X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23845170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Guevara, Amanda Ladrón</creatorcontrib><creatorcontrib>Crisosto, Nicolás</creatorcontrib><creatorcontrib>Echiburú, Bárbara</creatorcontrib><creatorcontrib>Preisler, Jessica</creatorcontrib><creatorcontrib>Vantman, Natalie</creatorcontrib><creatorcontrib>Bollmann, Josefina</creatorcontrib><creatorcontrib>Pérez-Bravo, Francisco</creatorcontrib><creatorcontrib>Sir-Petermann, Teresa</creatorcontrib><title>Evaluation of ovarian function in 35–40-year-old women with polycystic ovary syndrome</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objective To assess gonadotrophin secretion, ovarian steroid production and ovarian reserve in PCOS women during the onset of reproductive decline, in order to characterize their ovarian function at this age. Study design Forty PCOS patients and 35 healthy women (35–40 years of age) were included. Clinical history, anthropometry, transvaginal ultrasound and a leuprolide acetate test (10 μg/kg s.c.) were performed. Gonadotrophins, steroid hormones, SHBG, inhibin B and AMH were determined. Results Basal and peak LH levels were similar in both groups. Basal and peak FSH levels were significantly higher in the control group. Androgens, peak oestradiol, ovarian volume, antral follicle count and AMH levels were significantly higher in PCOS patients. Conclusion These observations suggest that during late reproductive age, gonadotrophin secretion in women with PCOS is clearly different from that observed in control women and may also differ from that of younger PCOS patients. New features like normal LH and lower FSH levels associated with a higher ovarian reserve may give a different reproductive profile to these women.</description><subject>Adult</subject><subject>Aging - physiology</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadal axis</subject><subject>Humans</subject><subject>Late reproductive age</subject><subject>Luteinizing Hormone - blood</subject><subject>Obstetrics and Gynecology</subject><subject>Ovarian reserve</subject><subject>Ovary - cytology</subject><subject>Ovary - physiopathology</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EokvhDaoqRy4JYzuxs5dKVdUWpEocAMHNcsZOccjaWzvZKjfegTfsk-DtFg5c8OWX7P-f8XxDyAmFigIV74bKDuE2dhUDyisQVZZnZEVbyUopmvo5WQEHWjJKmyPyKqUB8uF8_ZIcMd7WDZWwIl8vd3qc9eSCL0JfhJ2OTvuinz0-3jlf8Obh568aysXqWIbRFPdhY31x76bvxTaMCy5pcvgYXYq0eBPz-2vyotdjsm-e9Jh8ubr8fPG-vPl4_eHi_KbEmsqp7A0wLWjT1chRdnkuhrgGwRG1YZ2xkvfcYt33gEKA1G3D2k6YjufQujX8mLw91N3GcDfbNKmNS2jHUXsb5qRozVommZDrbK0PVowhpWh7tY1ukz-tKKg9UjWoA1K1R6pAqCw5dvrUYe421vwN_WGYDWcHg81z7pyNKqGzHq1x0eKkTHD_6_BvARydd6jHH3axaQhz9JmhoioxBerTfq37rVIOwCT_xn8DzGKfiA</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>de Guevara, Amanda Ladrón</creator><creator>Crisosto, Nicolás</creator><creator>Echiburú, Bárbara</creator><creator>Preisler, Jessica</creator><creator>Vantman, Natalie</creator><creator>Bollmann, Josefina</creator><creator>Pérez-Bravo, Francisco</creator><creator>Sir-Petermann, Teresa</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Evaluation of ovarian function in 35–40-year-old women with polycystic ovary syndrome</title><author>de Guevara, Amanda Ladrón ; Crisosto, Nicolás ; Echiburú, Bárbara ; Preisler, Jessica ; Vantman, Natalie ; Bollmann, Josefina ; Pérez-Bravo, Francisco ; Sir-Petermann, Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-fd02a615b4c3c7b0162cc9063ccad2bde73f3ec4ff0c6607a8528b6db361598d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aging - physiology</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadal axis</topic><topic>Humans</topic><topic>Late reproductive age</topic><topic>Luteinizing Hormone - blood</topic><topic>Obstetrics and Gynecology</topic><topic>Ovarian reserve</topic><topic>Ovary - cytology</topic><topic>Ovary - physiopathology</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Guevara, Amanda Ladrón</creatorcontrib><creatorcontrib>Crisosto, Nicolás</creatorcontrib><creatorcontrib>Echiburú, Bárbara</creatorcontrib><creatorcontrib>Preisler, Jessica</creatorcontrib><creatorcontrib>Vantman, Natalie</creatorcontrib><creatorcontrib>Bollmann, Josefina</creatorcontrib><creatorcontrib>Pérez-Bravo, Francisco</creatorcontrib><creatorcontrib>Sir-Petermann, Teresa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Guevara, Amanda Ladrón</au><au>Crisosto, Nicolás</au><au>Echiburú, Bárbara</au><au>Preisler, Jessica</au><au>Vantman, Natalie</au><au>Bollmann, Josefina</au><au>Pérez-Bravo, Francisco</au><au>Sir-Petermann, Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of ovarian function in 35–40-year-old women with polycystic ovary syndrome</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>170</volume><issue>1</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><abstract>Abstract Objective To assess gonadotrophin secretion, ovarian steroid production and ovarian reserve in PCOS women during the onset of reproductive decline, in order to characterize their ovarian function at this age. Study design Forty PCOS patients and 35 healthy women (35–40 years of age) were included. Clinical history, anthropometry, transvaginal ultrasound and a leuprolide acetate test (10 μg/kg s.c.) were performed. Gonadotrophins, steroid hormones, SHBG, inhibin B and AMH were determined. Results Basal and peak LH levels were similar in both groups. Basal and peak FSH levels were significantly higher in the control group. Androgens, peak oestradiol, ovarian volume, antral follicle count and AMH levels were significantly higher in PCOS patients. Conclusion These observations suggest that during late reproductive age, gonadotrophin secretion in women with PCOS is clearly different from that observed in control women and may also differ from that of younger PCOS patients. New features like normal LH and lower FSH levels associated with a higher ovarian reserve may give a different reproductive profile to these women.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23845170</pmid><doi>10.1016/j.ejogrb.2013.06.013</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aging - physiology Anti-Mullerian Hormone - blood Case-Control Studies Female Follicle Stimulating Hormone - blood Gonadal axis Humans Late reproductive age Luteinizing Hormone - blood Obstetrics and Gynecology Ovarian reserve Ovary - cytology Ovary - physiopathology Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - physiopathology |
| title | Evaluation of ovarian function in 35–40-year-old women with polycystic ovary syndrome |
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