Evidence for a Specific Uptake and Retention Mechanism for 25-Hydroxyvitamin D (25OHD) in Skeletal Muscle Cells

Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In vitro studies investigated the capacity of differentiated C2...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-09, Vol.154 (9), p.3022-3030
Hauptverfasser:	Abboud, M, Puglisi, D. A, Davies, B. N, Rybchyn, M, Whitehead, N. P, Brock, K. E, Cole, L, Gordon-Thomson, C, Fraser, D. R, Mason, R. S
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Actin Animals Biological and medical sciences Blood Calcifediol - blood Calcifediol - metabolism Cell Differentiation Cell Line Cells, Cultured Confocal microscopy Endocytosis Extracellular Fluid - metabolism Female Fundamental and applied biological sciences. Psychology Immunofluorescence Low Density Lipoprotein Receptor-Related Protein-2 - antagonists & inhibitors Low Density Lipoprotein Receptor-Related Protein-2 - metabolism Male Membranes Mice Mice, Inbred BALB C Motor Activity Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscles Musculoskeletal system Myoblasts Myoblasts, Skeletal - cytology Myoblasts, Skeletal - metabolism Myotubes Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Proteins Random Allocation Receptors Receptors, Cell Surface - metabolism Skeletal muscle Striated muscle. Tendons Time dependence Vertebrates: endocrinology Vertebrates: osteoarticular system, musculoskeletal system Vitamin D Vitamin D-Binding Protein - metabolism
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