Michaelis and Menten and the long road to the discovery of cooperativity
This article sketches the road from the establishment of the principles of enzyme kinetics, at the beginning of the 20th century, to the discovery of regulatory mechanisms and the models to explain them, from the middle of the century onwards. A long gap in time separates the two periods, in which t...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 2013-09, Vol.587 (17), p.2767-2771 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2771 |
|---|---|
| container_issue | 17 |
| container_start_page | 2767 |
| container_title | FEBS letters |
| container_volume | 587 |
| creator | Cárdenas, María Luz |
| description | This article sketches the road from the establishment of the principles of enzyme kinetics, at the beginning of the 20th century, to the discovery of regulatory mechanisms and the models to explain them, from the middle of the century onwards. A long gap in time separates the two periods, in which technological advances were made that allowed the discovery of feedback inhibition and cooperativity. In particular, these discoveries and the theory needed to explain them could not have been made without knowledge of the major metabolic pathways and the enzymes and metabolites involved in them. |
| doi_str_mv | 10.1016/j.febslet.2013.07.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1428272171</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014579313005292</els_id><sourcerecordid>1428272171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4302-8c4d9b2d9421573fc995f36fc030f1e2bc69f671cf3391cba73403e0b4e5a17a3</originalsourceid><addsrcrecordid>eNqNkU1P3DAQhq2qqGyhP6FVjr0keGwnjk9Vi6CLBOLQcrYcZ1y8ysaLnd1q_30ddssVTvOhd94ZPUPIZ6AVUGguVpXDLg04VYwCr6isKIh3ZAGt5CUXTfueLGhulbVU_JR8TGlFc92C-kBOGW_rRjRsQZZ33j4aHHwqzNgXdzhOOD6n0yMWQxj_FDGYXIXnRu-TDTuM-yK4woawwWgmv_PT_pycODMk_HSMZ-Th-ur35bK8vf95c_n9trSCU1a2VvSqY70SDGrJnVWqdrxxlnLqAFlnG-UaCdZxrsB2RnJBOdJOYG1AGn5Gvh58NzE8bTFNep1vwmEwI4Zt0iBYyyQDCVlaH6Q2hpQiOr2Jfm3iXgPVM0S90keIeoaoqdSZWJ77clyx7dbYv0z9p5YFy4Pgrx9w_zZXfX31g_2aPzI_BDilNVOz1beDFWZmO49RJ-txtNj7iHbSffCvXPsP4U6aMg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1428272171</pqid></control><display><type>article</type><title>Michaelis and Menten and the long road to the discovery of cooperativity</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>ScienceDirect Journals (5 years ago - present)</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Cárdenas, María Luz</creator><creatorcontrib>Cárdenas, María Luz</creatorcontrib><description>This article sketches the road from the establishment of the principles of enzyme kinetics, at the beginning of the 20th century, to the discovery of regulatory mechanisms and the models to explain them, from the middle of the century onwards. A long gap in time separates the two periods, in which technological advances were made that allowed the discovery of feedback inhibition and cooperativity. In particular, these discoveries and the theory needed to explain them could not have been made without knowledge of the major metabolic pathways and the enzymes and metabolites involved in them.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2013.07.014</identifier><identifier>PMID: 23856462</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Algorithms ; Allosteric Regulation ; Allostery ; Cooperativity ; Enzyme Assays ; Feedback ; Feedback, Physiological ; Glucokinase - chemistry ; Humans ; Kinetics ; Michaelis–Menten ; Models, Chemical</subject><ispartof>FEBS letters, 2013-09, Vol.587 (17), p.2767-2771</ispartof><rights>2013 Federation of European Biochemical Societies</rights><rights>FEBS Letters 587 (2013) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4302-8c4d9b2d9421573fc995f36fc030f1e2bc69f671cf3391cba73403e0b4e5a17a3</citedby><cites>FETCH-LOGICAL-c4302-8c4d9b2d9421573fc995f36fc030f1e2bc69f671cf3391cba73403e0b4e5a17a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2013.07.014$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2013.07.014$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3549,27923,27924,45573,45574,45994,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23856462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cárdenas, María Luz</creatorcontrib><title>Michaelis and Menten and the long road to the discovery of cooperativity</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>This article sketches the road from the establishment of the principles of enzyme kinetics, at the beginning of the 20th century, to the discovery of regulatory mechanisms and the models to explain them, from the middle of the century onwards. A long gap in time separates the two periods, in which technological advances were made that allowed the discovery of feedback inhibition and cooperativity. In particular, these discoveries and the theory needed to explain them could not have been made without knowledge of the major metabolic pathways and the enzymes and metabolites involved in them.</description><subject>Algorithms</subject><subject>Allosteric Regulation</subject><subject>Allostery</subject><subject>Cooperativity</subject><subject>Enzyme Assays</subject><subject>Feedback</subject><subject>Feedback, Physiological</subject><subject>Glucokinase - chemistry</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Michaelis–Menten</subject><subject>Models, Chemical</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhq2qqGyhP6FVjr0keGwnjk9Vi6CLBOLQcrYcZ1y8ysaLnd1q_30ddssVTvOhd94ZPUPIZ6AVUGguVpXDLg04VYwCr6isKIh3ZAGt5CUXTfueLGhulbVU_JR8TGlFc92C-kBOGW_rRjRsQZZ33j4aHHwqzNgXdzhOOD6n0yMWQxj_FDGYXIXnRu-TDTuM-yK4woawwWgmv_PT_pycODMk_HSMZ-Th-ur35bK8vf95c_n9trSCU1a2VvSqY70SDGrJnVWqdrxxlnLqAFlnG-UaCdZxrsB2RnJBOdJOYG1AGn5Gvh58NzE8bTFNep1vwmEwI4Zt0iBYyyQDCVlaH6Q2hpQiOr2Jfm3iXgPVM0S90keIeoaoqdSZWJ77clyx7dbYv0z9p5YFy4Pgrx9w_zZXfX31g_2aPzI_BDilNVOz1beDFWZmO49RJ-txtNj7iHbSffCvXPsP4U6aMg</recordid><startdate>20130902</startdate><enddate>20130902</enddate><creator>Cárdenas, María Luz</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130902</creationdate><title>Michaelis and Menten and the long road to the discovery of cooperativity</title><author>Cárdenas, María Luz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4302-8c4d9b2d9421573fc995f36fc030f1e2bc69f671cf3391cba73403e0b4e5a17a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Algorithms</topic><topic>Allosteric Regulation</topic><topic>Allostery</topic><topic>Cooperativity</topic><topic>Enzyme Assays</topic><topic>Feedback</topic><topic>Feedback, Physiological</topic><topic>Glucokinase - chemistry</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Michaelis–Menten</topic><topic>Models, Chemical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cárdenas, María Luz</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cárdenas, María Luz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Michaelis and Menten and the long road to the discovery of cooperativity</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2013-09-02</date><risdate>2013</risdate><volume>587</volume><issue>17</issue><spage>2767</spage><epage>2771</epage><pages>2767-2771</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>This article sketches the road from the establishment of the principles of enzyme kinetics, at the beginning of the 20th century, to the discovery of regulatory mechanisms and the models to explain them, from the middle of the century onwards. A long gap in time separates the two periods, in which technological advances were made that allowed the discovery of feedback inhibition and cooperativity. In particular, these discoveries and the theory needed to explain them could not have been made without knowledge of the major metabolic pathways and the enzymes and metabolites involved in them.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>23856462</pmid><doi>10.1016/j.febslet.2013.07.014</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2013-09, Vol.587 (17), p.2767-2771 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1428272171 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; ScienceDirect Journals (5 years ago - present); Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Algorithms Allosteric Regulation Allostery Cooperativity Enzyme Assays Feedback Feedback, Physiological Glucokinase - chemistry Humans Kinetics Michaelis–Menten Models, Chemical |
| title | Michaelis and Menten and the long road to the discovery of cooperativity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T08%3A29%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Michaelis%20and%20Menten%20and%20the%20long%20road%20to%20the%20discovery%20of%20cooperativity&rft.jtitle=FEBS%20letters&rft.au=C%C3%A1rdenas,%20Mar%C3%ADa%20Luz&rft.date=2013-09-02&rft.volume=587&rft.issue=17&rft.spage=2767&rft.epage=2771&rft.pages=2767-2771&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/j.febslet.2013.07.014&rft_dat=%3Cproquest_cross%3E1428272171%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1428272171&rft_id=info:pmid/23856462&rft_els_id=S0014579313005292&rfr_iscdi=true |