Full-Length Human Chromogranin-A Cardioactivity: Myocardial, Coronary, and Stimulus-Induced Processing Evidence in Normotensive and Hypertensive Male Rat Hearts

Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an antiadrenergic/nitric oxide-cGMP mediated mechanism. Whether these phenomena are related is unknown. We here investigated whether...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-09, Vol.154 (9), p.3353-3365
Hauptverfasser:	Pasqua, Teresa, Corti, Angelo, Gentile, Stefano, Pochini, Lorena, Bianco, Mimma, Metz-Boutigue, Marie-Hélène, Cerra, Maria Carmela, Tota, Bruno, Angelone, Tommaso
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Affinity chromatography AKT protein Allostasis Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiotonic Agents - pharmacology Cardiovascular diseases Chromogranin A - metabolism Coronary Circulation - drug effects Coronary Vessels - drug effects Coronary Vessels - metabolism Cyclic GMP Endothelin 1 Endothelin-1 - agonists Endothelin-1 - metabolism Experimental diseases Fragments Fundamental and applied biological sciences. Psychology Heart - drug effects Heart diseases Hemodynamics Homeostasis Hypertension Hypertension - drug therapy Hypertension - metabolism In Vitro Techniques Information processing Inotropism Kinases Male Medical sciences Myocardial Contraction - drug effects Myocardium - metabolism Nitric oxide Nitric-oxide synthase Osmolar Concentration Perfusion Phosphorylation Protein kinase G Proteolysis - drug effects Rats Rats, Inbred SHR Rats, Inbred WKY Rats, Wistar Second Messenger Systems - drug effects Signal transduction Stimulation Vasodilation - drug effects Vertebrates: endocrinology Western blotting
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