Synthetic biology: Tools to design microbes for the production of chemicals and fuels

The engineering of biological systems to achieve specific purposes requires design tools that function in a predictable and quantitative manner. Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have incre...

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Veröffentlicht in:Biotechnology advances 2013-11, Vol.31 (6), p.811-817
Hauptverfasser: Seo, Sang Woo, Yang, Jina, Min, Byung Eun, Jang, Sungho, Lim, Jae Hyung, Lim, Hyun Gyu, Kim, Seong Cheol, Kim, Se Yeon, Jeong, Jun Hong, Jung, Gyoo Yeol
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container_end_page 817
container_issue 6
container_start_page 811
container_title Biotechnology advances
container_volume 31
creator Seo, Sang Woo
Yang, Jina
Min, Byung Eun
Jang, Sungho
Lim, Jae Hyung
Lim, Hyun Gyu
Kim, Seong Cheol
Kim, Se Yeon
Jeong, Jun Hong
Jung, Gyoo Yeol
description The engineering of biological systems to achieve specific purposes requires design tools that function in a predictable and quantitative manner. Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have increased our ability to efficiently design and optimize biological systems to perform designed tasks. Furthermore, implementation of these designs in biological systems highlights the potential of using these tools to build microbial cell factories for the production of chemicals and fuels. In this paper, we review current developments in the design of tools for controlling gene expression at transcriptional, post-transcriptional and post-translational levels, and consider potential applications of these tools.
doi_str_mv 10.1016/j.biotechadv.2013.03.012
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subjects Biochemical
Biofuel
Biofuel production
Biofuels - microbiology
Biological and medical sciences
Biotechnology
Energy
Expression control
Fermentation - genetics
fuels
Fundamental and applied biological sciences. Psychology
gene expression
Genetic Engineering - methods
Industrial applications and implications. Economical aspects
Industrial Microbiology - statistics & numerical data
Industrial Microbiology - trends
Metabolic engineering
Microbial cell factory
microorganisms
Synthetic biology
Synthetic Biology - trends
Systems Biology - trends
transcription (genetics)
title Synthetic biology: Tools to design microbes for the production of chemicals and fuels
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