Synthetic biology: Tools to design microbes for the production of chemicals and fuels
The engineering of biological systems to achieve specific purposes requires design tools that function in a predictable and quantitative manner. Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have incre...
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Veröffentlicht in: | Biotechnology advances 2013-11, Vol.31 (6), p.811-817 |
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container_title | Biotechnology advances |
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creator | Seo, Sang Woo Yang, Jina Min, Byung Eun Jang, Sungho Lim, Jae Hyung Lim, Hyun Gyu Kim, Seong Cheol Kim, Se Yeon Jeong, Jun Hong Jung, Gyoo Yeol |
description | The engineering of biological systems to achieve specific purposes requires design tools that function in a predictable and quantitative manner. Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have increased our ability to efficiently design and optimize biological systems to perform designed tasks. Furthermore, implementation of these designs in biological systems highlights the potential of using these tools to build microbial cell factories for the production of chemicals and fuels. In this paper, we review current developments in the design of tools for controlling gene expression at transcriptional, post-transcriptional and post-translational levels, and consider potential applications of these tools. |
doi_str_mv | 10.1016/j.biotechadv.2013.03.012 |
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Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have increased our ability to efficiently design and optimize biological systems to perform designed tasks. Furthermore, implementation of these designs in biological systems highlights the potential of using these tools to build microbial cell factories for the production of chemicals and fuels. 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Economical aspects ; Industrial Microbiology - statistics & numerical data ; Industrial Microbiology - trends ; Metabolic engineering ; Microbial cell factory ; microorganisms ; Synthetic biology ; Synthetic Biology - trends ; Systems Biology - trends ; transcription (genetics)</subject><ispartof>Biotechnology advances, 2013-11, Vol.31 (6), p.811-817</ispartof><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. 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Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have increased our ability to efficiently design and optimize biological systems to perform designed tasks. Furthermore, implementation of these designs in biological systems highlights the potential of using these tools to build microbial cell factories for the production of chemicals and fuels. 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subjects | Biochemical Biofuel Biofuel production Biofuels - microbiology Biological and medical sciences Biotechnology Energy Expression control Fermentation - genetics fuels Fundamental and applied biological sciences. Psychology gene expression Genetic Engineering - methods Industrial applications and implications. Economical aspects Industrial Microbiology - statistics & numerical data Industrial Microbiology - trends Metabolic engineering Microbial cell factory microorganisms Synthetic biology Synthetic Biology - trends Systems Biology - trends transcription (genetics) |
title | Synthetic biology: Tools to design microbes for the production of chemicals and fuels |
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