Qualitative Rather than Quantitative Changes Are Hallmarks of Fibroblasts in Bleomycin-Induced Pulmonary Fibrosis

Pulmonary fibrosis is characterized by accumulation of activated fibroblasts that produce excessive amounts of extracellular matrix components such as collagen type I. However, the dynamics and activation signatures of fibroblasts during fibrogenesis remain poorly understood, especially in vivo . We...

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Veröffentlicht in:	The American journal of pathology 2013-09, Vol.183 (3), p.758-773
Hauptverfasser:	Tsukui, Tatsuya, Ueha, Satoshi, Abe, Jun, Hashimoto, Shin-ichi, Shichino, Shigeyuki, Shimaoka, Takeshi, Shand, Francis H.W, Arakawa, Yasuka, Oshima, Kenshiro, Hattori, Masahira, Inagaki, Yutaka, Tomura, Michio, Matsushima, Kouji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers - metabolism Bleomycin Bone Marrow Cells - pathology Cell Proliferation Collagen Type I - metabolism Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Profiling Gene Ontology Green Fluorescent Proteins - metabolism Lung - metabolism Lung - pathology Mice Mice, Inbred C57BL Osteopontin - metabolism Pathology Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Recombinant Fusion Proteins - metabolism Up-Regulation - genetics
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