The Complement Cascade in Kidney Disease: From Sideline to Center Stage
Activation of the complement pathway is implicated in the pathogenesis of many kidney diseases. The pathologic and clinical features of these diseases are determined in part by the mechanism and location of complement activation within the kidney parenchyma. This review describes the physiology, act...
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| Veröffentlicht in: | American journal of kidney diseases 2013-09, Vol.62 (3), p.604-614 |
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| container_title | American journal of kidney diseases |
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| creator | McCaughan, Jennifer A., MBChB O'Rourke, Declan M., MBChB, BAO Courtney, Aisling E., MBChB, BAO, MPhil |
| description | Activation of the complement pathway is implicated in the pathogenesis of many kidney diseases. The pathologic and clinical features of these diseases are determined in part by the mechanism and location of complement activation within the kidney parenchyma. This review describes the physiology, action, and control of the complement cascade and explains the role of complement overactivation and dysregulation in kidney disease. There have been recent advances in the understanding of the effects of upregulation of the complement cascade after kidney transplantation. Complement plays an important role in initiating and propagating damage to transplanted kidneys in ischemia-reperfusion injury, antibody-mediated rejection, and cell-mediated rejection. Complement-targeting therapies presently are in development, and the first direct complement medication for kidney disease was licensed in 2011. The potential therapeutic targets for anticomplement drugs in kidney disease are described. Clinical and experimental studies are ongoing to identify further roles for complement-targeting therapy. |
| doi_str_mv | 10.1053/j.ajkd.2012.12.033 |
| format | Article |
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The pathologic and clinical features of these diseases are determined in part by the mechanism and location of complement activation within the kidney parenchyma. This review describes the physiology, action, and control of the complement cascade and explains the role of complement overactivation and dysregulation in kidney disease. There have been recent advances in the understanding of the effects of upregulation of the complement cascade after kidney transplantation. Complement plays an important role in initiating and propagating damage to transplanted kidneys in ischemia-reperfusion injury, antibody-mediated rejection, and cell-mediated rejection. Complement-targeting therapies presently are in development, and the first direct complement medication for kidney disease was licensed in 2011. The potential therapeutic targets for anticomplement drugs in kidney disease are described. Clinical and experimental studies are ongoing to identify further roles for complement-targeting therapy.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2012.12.033</identifier><identifier>PMID: 23489674</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Complement activation ; complement dysregulation ; Complement Pathway, Alternative - immunology ; Complement Pathway, Classical - immunology ; Complement System Proteins - immunology ; Complement System Proteins - metabolism ; Female ; Humans ; kidney disease ; Kidney Diseases - diagnosis ; Kidney Diseases - immunology ; Kidney Diseases - metabolism ; Medical sciences ; Nephrology ; Nephrology. 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The pathologic and clinical features of these diseases are determined in part by the mechanism and location of complement activation within the kidney parenchyma. This review describes the physiology, action, and control of the complement cascade and explains the role of complement overactivation and dysregulation in kidney disease. There have been recent advances in the understanding of the effects of upregulation of the complement cascade after kidney transplantation. Complement plays an important role in initiating and propagating damage to transplanted kidneys in ischemia-reperfusion injury, antibody-mediated rejection, and cell-mediated rejection. Complement-targeting therapies presently are in development, and the first direct complement medication for kidney disease was licensed in 2011. The potential therapeutic targets for anticomplement drugs in kidney disease are described. Clinical and experimental studies are ongoing to identify further roles for complement-targeting therapy.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Complement activation</subject><subject>complement dysregulation</subject><subject>Complement Pathway, Alternative - immunology</subject><subject>Complement Pathway, Classical - immunology</subject><subject>Complement System Proteins - immunology</subject><subject>Complement System Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>kidney disease</subject><subject>Kidney Diseases - diagnosis</subject><subject>Kidney Diseases - immunology</subject><subject>Kidney Diseases - metabolism</subject><subject>Medical sciences</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuLFDEURoMoTjv6B1xINoKbavNORUSQ0nkwAy56BHchndzS1NSjTaqF_vem6NYBF8KFbM733XAuQi8pWVMi-dtu7br7sGaEsnUZwvkjtKKS8UrVvH6MVoRpVileqzP0LOeOEGK4Uk_RGeOiNkqLFbq8-wG4mYZdDwOMM25c9i4AjiO-iWGEA_4UM7gM7_BFmga8iQH6OAKeJ9yUACS8md13eI6etK7P8OL0nqOvF5_vmqvq9svldfPxtvJC0LnitWRMCs4lCKK3WgsDLHDjOBdC1sbr2vPWGLYVrSSMBG2kIaAY0z4w3_Jz9ObYu0vTzz3k2Q4xe-h7N8K0z5YKVjNNyrKCsiPq05RzgtbuUhxcOlhK7CLQdnYRaBeBtkwRWEKvTv377QDhb-SPsQK8PgGLqb5NbvQxP3BaKS3lwr0_clBs_IqQbPYRRg8hJvCzDVP8_z8-_BP3RXssG-_hALmb9mksni21uQTsZjn1cmnKSWmR3_hv1dmf6Q</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>McCaughan, Jennifer A., MBChB</creator><creator>O'Rourke, Declan M., MBChB, BAO</creator><creator>Courtney, Aisling E., MBChB, BAO, MPhil</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>The Complement Cascade in Kidney Disease: From Sideline to Center Stage</title><author>McCaughan, Jennifer A., MBChB ; O'Rourke, Declan M., MBChB, BAO ; Courtney, Aisling E., MBChB, BAO, MPhil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-3852254335e407b7749e2d39a3344589c78c3f992b4f5020d79590e6227cd2cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Complement activation</topic><topic>complement dysregulation</topic><topic>Complement Pathway, Alternative - immunology</topic><topic>Complement Pathway, Classical - immunology</topic><topic>Complement System Proteins - immunology</topic><topic>Complement System Proteins - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>kidney disease</topic><topic>Kidney Diseases - diagnosis</topic><topic>Kidney Diseases - immunology</topic><topic>Kidney Diseases - metabolism</topic><topic>Medical sciences</topic><topic>Nephrology</topic><topic>Nephrology. 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The pathologic and clinical features of these diseases are determined in part by the mechanism and location of complement activation within the kidney parenchyma. This review describes the physiology, action, and control of the complement cascade and explains the role of complement overactivation and dysregulation in kidney disease. There have been recent advances in the understanding of the effects of upregulation of the complement cascade after kidney transplantation. Complement plays an important role in initiating and propagating damage to transplanted kidneys in ischemia-reperfusion injury, antibody-mediated rejection, and cell-mediated rejection. Complement-targeting therapies presently are in development, and the first direct complement medication for kidney disease was licensed in 2011. The potential therapeutic targets for anticomplement drugs in kidney disease are described. Clinical and experimental studies are ongoing to identify further roles for complement-targeting therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23489674</pmid><doi>10.1053/j.ajkd.2012.12.033</doi><tpages>11</tpages></addata></record> |
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| ispartof | American journal of kidney diseases, 2013-09, Vol.62 (3), p.604-614 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biological and medical sciences Complement activation complement dysregulation Complement Pathway, Alternative - immunology Complement Pathway, Classical - immunology Complement System Proteins - immunology Complement System Proteins - metabolism Female Humans kidney disease Kidney Diseases - diagnosis Kidney Diseases - immunology Kidney Diseases - metabolism Medical sciences Nephrology Nephrology. Urinary tract diseases |
| title | The Complement Cascade in Kidney Disease: From Sideline to Center Stage |
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