Pentylentetrazole-induced loss of blood–brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase

Abstract Dysfunction of the blood–brain barrier (BBB) is one of the major pathophysiological consequences of epilepsy. The increase in the permeability caused by BBB failure is thought to contribute to the development of epileptic outcomes. We developed a method by which the BBB permeability can be...

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Veröffentlicht in:	Brain research 2013-09, Vol.1530, p.44-53
Hauptverfasser:	Danjo, Sonoko, Ishihara, Yasuhiro, Watanabe, Masatomo, Nakamura, Yu, Itoh, Kouichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood-Brain Barrier - metabolism Blood–brain barrier Brain - metabolism Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges cerebral cortex drugs epilepsy Fundamental and applied biological sciences. Psychology Gd-HP-DO3A Generalized convulsive seizures Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hippocampus image analysis Male Medical sciences Mice Mice, Inbred ICR MRI Nervous system (semeiology, syndromes) Neurology neuronal nitric oxide synthase Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism parenchyma Pentylenetetrazole Pentylenetetrazole - pharmacology permeability seizures Seizures - chemically induced Seizures - metabolism Vertebrates: nervous system and sense organs
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