Effect of Different Pump Heads for CPB on Early Cognitive Outcome after Coronary Artery Bypass Surgery
Objectives: Reduction of cognitive function is a possible side effect after coronary artery surgery using cardiopulmonary bypass (CPB). We investigated the effect of roller versus centrifugal pumps for CPB on cognitive performance in patients undergoing coronary artery bypass grafting (CABG).Methods...
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| Veröffentlicht in: | Annals of Thoracic and Cardiovascular Surgery 2013/08/20, Vol.19(4), pp.273-278 |
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| creator | Holinski, Sebastian Claus, Benjamin Haeger, Nicole Neumann, Konrad Uebelhack, Ralf Konertz, Wolfgang |
| description | Objectives: Reduction of cognitive function is a possible side effect after coronary artery surgery using cardiopulmonary bypass (CPB). We investigated the effect of roller versus centrifugal pumps for CPB on cognitive performance in patients undergoing coronary artery bypass grafting (CABG).Methods: 50 consecutive CABG patients operated with centrifugal pump were compared to 50 roller pump patients matched for age and duration of CPB. Six neuropsychological subtests from the Syndrom Kurz Test and the Alzheimer's Disease Assessment Scale were performed preoperatively and on the third postoperative day in a double blind fashion. To assess the overall cognitive function and the degree of cognitive decline across all tests after surgery we combined the six test-scores by principal component analysis.Results: Patients with a mean age of 63.9±8.4 years received a mean of 3.0±0.9 bypasses within an average of 80.6±20.7 mins on CPB. These parameters as well as the preoperative combined neurocognitive score were not significantly different between the groups. After the operation there was a significant deterioration of the combined neuropsychological score in both groups (centrifugal: preop 0.41±2.49 vs.postop −2.86±2.70, p |
| doi_str_mv | 10.5761/atcs.oa.12.01938 |
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We investigated the effect of roller versus centrifugal pumps for CPB on cognitive performance in patients undergoing coronary artery bypass grafting (CABG).Methods: 50 consecutive CABG patients operated with centrifugal pump were compared to 50 roller pump patients matched for age and duration of CPB. Six neuropsychological subtests from the Syndrom Kurz Test and the Alzheimer's Disease Assessment Scale were performed preoperatively and on the third postoperative day in a double blind fashion. To assess the overall cognitive function and the degree of cognitive decline across all tests after surgery we combined the six test-scores by principal component analysis.Results: Patients with a mean age of 63.9±8.4 years received a mean of 3.0±0.9 bypasses within an average of 80.6±20.7 mins on CPB. These parameters as well as the preoperative combined neurocognitive score were not significantly different between the groups. After the operation there was a significant deterioration of the combined neuropsychological score in both groups (centrifugal: preop 0.41±2.49 vs.postop −2.86±2.70, p <0.0005 and roller: preop −0.41±2.35 vs. postop −2.73±3.16, p <0.0005). However, the patients operated with a centrifugal pump had a significantly greater decline of overall cognitive function compared to the roller pump patients(3.3±1.7 vs. 2.3±2.7, p = 0.04).Conclusion: Roller pumps have a less cerebro-damaging effect than centrifugal pumps since they lead to a smaller postoperative decline of neuropsychological abilities in coronary bypass patients.</description><identifier>ISSN: 1341-1098</identifier><identifier>EISSN: 2186-1005</identifier><identifier>DOI: 10.5761/atcs.oa.12.01938</identifier><identifier>PMID: 23237983</identifier><language>eng</language><publisher>Japan: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery</publisher><subject>Aged ; Aged, 80 and over ; Attention ; cardiopulmonary bypass ; Cardiopulmonary Bypass - adverse effects ; Cardiopulmonary Bypass - instrumentation ; Cognition ; cognition disorders ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Cognition Disorders - prevention & control ; Cognition Disorders - psychology ; Coronary Artery Bypass - adverse effects ; coronary artery bypass surgery ; Double-Blind Method ; Equipment Design ; Female ; Humans ; Male ; Mental Recall ; Middle Aged ; Neuropsychological Tests ; Predictive Value of Tests ; Principal Component Analysis ; Recognition (Psychology) ; Time Factors ; Treatment Outcome</subject><ispartof>Annals of Thoracic and Cardiovascular Surgery, 2013/08/20, Vol.19(4), pp.273-278</ispartof><rights>2013 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-d3045df9b0b1568f705ea39da5d4d46a11ee8ddba5612069a63b912716cd235a3</citedby><cites>FETCH-LOGICAL-c595t-d3045df9b0b1568f705ea39da5d4d46a11ee8ddba5612069a63b912716cd235a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23237983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holinski, Sebastian</creatorcontrib><creatorcontrib>Claus, Benjamin</creatorcontrib><creatorcontrib>Haeger, Nicole</creatorcontrib><creatorcontrib>Neumann, Konrad</creatorcontrib><creatorcontrib>Uebelhack, Ralf</creatorcontrib><creatorcontrib>Konertz, Wolfgang</creatorcontrib><title>Effect of Different Pump Heads for CPB on Early Cognitive Outcome after Coronary Artery Bypass Surgery</title><title>Annals of Thoracic and Cardiovascular Surgery</title><addtitle>ATCS</addtitle><description>Objectives: Reduction of cognitive function is a possible side effect after coronary artery surgery using cardiopulmonary bypass (CPB). We investigated the effect of roller versus centrifugal pumps for CPB on cognitive performance in patients undergoing coronary artery bypass grafting (CABG).Methods: 50 consecutive CABG patients operated with centrifugal pump were compared to 50 roller pump patients matched for age and duration of CPB. Six neuropsychological subtests from the Syndrom Kurz Test and the Alzheimer's Disease Assessment Scale were performed preoperatively and on the third postoperative day in a double blind fashion. To assess the overall cognitive function and the degree of cognitive decline across all tests after surgery we combined the six test-scores by principal component analysis.Results: Patients with a mean age of 63.9±8.4 years received a mean of 3.0±0.9 bypasses within an average of 80.6±20.7 mins on CPB. These parameters as well as the preoperative combined neurocognitive score were not significantly different between the groups. After the operation there was a significant deterioration of the combined neuropsychological score in both groups (centrifugal: preop 0.41±2.49 vs.postop −2.86±2.70, p <0.0005 and roller: preop −0.41±2.35 vs. postop −2.73±3.16, p <0.0005). However, the patients operated with a centrifugal pump had a significantly greater decline of overall cognitive function compared to the roller pump patients(3.3±1.7 vs. 2.3±2.7, p = 0.04).Conclusion: Roller pumps have a less cerebro-damaging effect than centrifugal pumps since they lead to a smaller postoperative decline of neuropsychological abilities in coronary bypass patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Attention</subject><subject>cardiopulmonary bypass</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Cardiopulmonary Bypass - instrumentation</subject><subject>Cognition</subject><subject>cognition disorders</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - prevention & control</subject><subject>Cognition Disorders - psychology</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>coronary artery bypass surgery</subject><subject>Double-Blind Method</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mental Recall</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Predictive Value of Tests</subject><subject>Principal Component Analysis</subject><subject>Recognition (Psychology)</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1341-1098</issn><issn>2186-1005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1rGzEQxUVoSdy0956Kjr3Y1Ugr7eqYuE5TCCTQ9ixm9eFu2F25krbg_z7rODG5zMyD33swj5DPwFayVvANi82riCvgKwZaNGdkwaFRS2BMviMLEBXMt24uyIecHxkTjVLsnFxwwUWtG7EgYROCt4XGQL9385n8WOjDNOzorUeXaYiJrh-uaRzpBlO_p-u4HbvS_ff0fio2Dp5iKH6GYoojpj29SrPc0-v9DnOmv6a0neVH8j5gn_2nl31J_txsfq9vl3f3P36ur-6WVmpZlk6wSrqgW9aCVE2omfQotEPpKlcpBPC-ca5FqYAzpVGJVgOvQVnHhURxSb4ec3cp_pt8LmbosvV9j6OPUzZQ8bqumkbBjLIjalPMOflgdqkb5g8MMHNo1xzaNRENcPPc7mz58pI-tYN3J8NrnTNwcwQec8GtPwGYSmd7f0wEbarDeJN8AuxfTMaP4gnCM5AO</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Holinski, Sebastian</creator><creator>Claus, Benjamin</creator><creator>Haeger, Nicole</creator><creator>Neumann, Konrad</creator><creator>Uebelhack, Ralf</creator><creator>Konertz, Wolfgang</creator><general>The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Effect of Different Pump Heads for CPB on Early Cognitive Outcome after Coronary Artery Bypass Surgery</title><author>Holinski, Sebastian ; Claus, Benjamin ; Haeger, Nicole ; Neumann, Konrad ; Uebelhack, Ralf ; Konertz, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-d3045df9b0b1568f705ea39da5d4d46a11ee8ddba5612069a63b912716cd235a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Attention</topic><topic>cardiopulmonary bypass</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Cardiopulmonary Bypass - instrumentation</topic><topic>Cognition</topic><topic>cognition disorders</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - prevention & control</topic><topic>Cognition Disorders - psychology</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>coronary artery bypass surgery</topic><topic>Double-Blind Method</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mental Recall</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Predictive Value of Tests</topic><topic>Principal Component Analysis</topic><topic>Recognition (Psychology)</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Holinski, Sebastian</creatorcontrib><creatorcontrib>Claus, Benjamin</creatorcontrib><creatorcontrib>Haeger, Nicole</creatorcontrib><creatorcontrib>Neumann, Konrad</creatorcontrib><creatorcontrib>Uebelhack, Ralf</creatorcontrib><creatorcontrib>Konertz, Wolfgang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of Thoracic and Cardiovascular Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holinski, Sebastian</au><au>Claus, Benjamin</au><au>Haeger, Nicole</au><au>Neumann, Konrad</au><au>Uebelhack, Ralf</au><au>Konertz, Wolfgang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Different Pump Heads for CPB on Early Cognitive Outcome after Coronary Artery Bypass Surgery</atitle><jtitle>Annals of Thoracic and Cardiovascular Surgery</jtitle><addtitle>ATCS</addtitle><date>2013</date><risdate>2013</risdate><volume>19</volume><issue>4</issue><spage>273</spage><epage>278</epage><pages>273-278</pages><issn>1341-1098</issn><eissn>2186-1005</eissn><abstract>Objectives: Reduction of cognitive function is a possible side effect after coronary artery surgery using cardiopulmonary bypass (CPB). We investigated the effect of roller versus centrifugal pumps for CPB on cognitive performance in patients undergoing coronary artery bypass grafting (CABG).Methods: 50 consecutive CABG patients operated with centrifugal pump were compared to 50 roller pump patients matched for age and duration of CPB. Six neuropsychological subtests from the Syndrom Kurz Test and the Alzheimer's Disease Assessment Scale were performed preoperatively and on the third postoperative day in a double blind fashion. To assess the overall cognitive function and the degree of cognitive decline across all tests after surgery we combined the six test-scores by principal component analysis.Results: Patients with a mean age of 63.9±8.4 years received a mean of 3.0±0.9 bypasses within an average of 80.6±20.7 mins on CPB. These parameters as well as the preoperative combined neurocognitive score were not significantly different between the groups. After the operation there was a significant deterioration of the combined neuropsychological score in both groups (centrifugal: preop 0.41±2.49 vs.postop −2.86±2.70, p <0.0005 and roller: preop −0.41±2.35 vs. postop −2.73±3.16, p <0.0005). However, the patients operated with a centrifugal pump had a significantly greater decline of overall cognitive function compared to the roller pump patients(3.3±1.7 vs. 2.3±2.7, p = 0.04).Conclusion: Roller pumps have a less cerebro-damaging effect than centrifugal pumps since they lead to a smaller postoperative decline of neuropsychological abilities in coronary bypass patients.</abstract><cop>Japan</cop><pub>The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery</pub><pmid>23237983</pmid><doi>10.5761/atcs.oa.12.01938</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Attention cardiopulmonary bypass Cardiopulmonary Bypass - adverse effects Cardiopulmonary Bypass - instrumentation Cognition cognition disorders Cognition Disorders - diagnosis Cognition Disorders - etiology Cognition Disorders - prevention & control Cognition Disorders - psychology Coronary Artery Bypass - adverse effects coronary artery bypass surgery Double-Blind Method Equipment Design Female Humans Male Mental Recall Middle Aged Neuropsychological Tests Predictive Value of Tests Principal Component Analysis Recognition (Psychology) Time Factors Treatment Outcome |
| title | Effect of Different Pump Heads for CPB on Early Cognitive Outcome after Coronary Artery Bypass Surgery |
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