Transcriptional and post-transcriptional regulation of IκB-ζ upon engagement of the BCR, TLRs and FcγR

IκB-ζ is a nuclear IκB protein robustly induced in macrophages and fibroblasts upon TLR or IL-1R stimulation. IκB-ζ associates with NF-κB in the cell nucleus and is essential for the induction of a subset of secondary response genes represented by IL-6. Here, we analyzed induction of IκB-ζ in mouse...

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Veröffentlicht in:	International immunology 2013-09, Vol.25 (9), p.531-544
Hauptverfasser:	Hanihara, Fumito, Takahashi, Yuta, Okuma, Atsushi, Ohba, Tomoyuki, Muta, Tatsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Animals Cell Line Chromones - pharmacology Mice Morpholines - pharmacology Nuclear Proteins - genetics Nuclear Proteins - immunology Proto-Oncogene Proteins c-bcr - antagonists & inhibitors Proto-Oncogene Proteins c-bcr - immunology Receptors, IgG - immunology Structure-Activity Relationship Toll-Like Receptors - immunology Transcription, Genetic - genetics
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