Disrupting proton dynamics and energy metabolism for cancer therapy

Key Points In rapidly growing cancer cells, oncogenes and hypoxia stimulate glycolytic metabolism, which generates increased amounts of lactic and carbonic acids. Several pH-regulating systems — Na + /H + exchangers (NHEs), carbonic anhydrases (CAIX and CAXII), HCO 3 − transporters, lactate/H + symp...

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Veröffentlicht in:	Nature reviews. Cancer 2013-09, Vol.13 (9), p.611-623
Hauptverfasser:	Parks, Scott K., Chiche, Johanna, Pouysségur, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/153 631/67/2327 692/308/153 692/699/67/1059/153 692/699/67/2327 Autophagy Bicarbonates - metabolism Bioenergetics Biomedicine Cancer Cancer Research Carbonic Acid - metabolism Carbonic Anhydrases - metabolism Care and treatment Cation Transport Proteins - metabolism Energy Metabolism Humans Hydrogen-Ion Concentration Hypoxia-Inducible Factor 1 - metabolism Lactic Acid - metabolism Monocarboxylic Acid Transporters - metabolism Muscle Proteins - metabolism Neoplasms - drug therapy Neoplasms - metabolism Physiological aspects Protons review-article Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers - metabolism Symporters - metabolism Tumor Microenvironment
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