Effect of polychlorinated biphenyls on several endocrine reproductive parameters in the female rhesus monkey
Female rhesus monkeys (Macaca mulatta) ingested gelatin capsules containing daily doses of 0 (control), 5, 20, 40, or 80 micrograms of Aroclor 1254/kg/day (PCB) which was dissolved in corn oil plus glycerol. After approximately two years of dosing and when the monkeys were near an adipose tissue PCB...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 1990-11, Vol.19 (6), p.939-943 |
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| creator | Truelove, J.F. (Health and Welfare Canada, Ottawa, Ontario, Canada) Tanner, J.R Langlois, I.A Stapley, R.A Arnold, D.L Mes, J.C |
| description | Female rhesus monkeys (Macaca mulatta) ingested gelatin capsules containing daily doses of 0 (control), 5, 20, 40, or 80 micrograms of Aroclor 1254/kg/day (PCB) which was dissolved in corn oil plus glycerol. After approximately two years of dosing and when the monkeys were near an adipose tissue PCBs equilibrium, each dose group of 16 animals was randomly divided into two test groups. Daily blood samples from both groups were acquired for estrogen and progesterone analysis during one menstrual cycle. Test group 1 was sampled during February-March and test group 2 during August-September. Serum estrogen and progesterone concentrations in monkeys dosed with PCBs were equivalent to control values with the exception of the luteal phase progesterone levels in the 20 and 80 micrograms/kg/day dosed monkeys in test group 1. There was no difference in menstrual cycle length between control and treated monkeys for the month sampled, however, menses duration was marginally longer in the 80 micrograms/kg/day dose group. There were no apparent treatment related differences in the incidence of anovulatory cycles nor on the temporal relationship between the estrogen peak and menses onset, menses end or the progesterone peak. |
| doi_str_mv | 10.1007/BF01055065 |
| format | Article |
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(Health and Welfare Canada, Ottawa, Ontario, Canada) ; Tanner, J.R ; Langlois, I.A ; Stapley, R.A ; Arnold, D.L ; Mes, J.C</creator><creatorcontrib>Truelove, J.F. (Health and Welfare Canada, Ottawa, Ontario, Canada) ; Tanner, J.R ; Langlois, I.A ; Stapley, R.A ; Arnold, D.L ; Mes, J.C</creatorcontrib><description>Female rhesus monkeys (Macaca mulatta) ingested gelatin capsules containing daily doses of 0 (control), 5, 20, 40, or 80 micrograms of Aroclor 1254/kg/day (PCB) which was dissolved in corn oil plus glycerol. After approximately two years of dosing and when the monkeys were near an adipose tissue PCBs equilibrium, each dose group of 16 animals was randomly divided into two test groups. Daily blood samples from both groups were acquired for estrogen and progesterone analysis during one menstrual cycle. Test group 1 was sampled during February-March and test group 2 during August-September. Serum estrogen and progesterone concentrations in monkeys dosed with PCBs were equivalent to control values with the exception of the luteal phase progesterone levels in the 20 and 80 micrograms/kg/day dosed monkeys in test group 1. There was no difference in menstrual cycle length between control and treated monkeys for the month sampled, however, menses duration was marginally longer in the 80 micrograms/kg/day dose group. There were no apparent treatment related differences in the incidence of anovulatory cycles nor on the temporal relationship between the estrogen peak and menses onset, menses end or the progesterone peak.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/BF01055065</identifier><identifier>PMID: 2124092</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>Animals ; BIFENILOS POLICLORADOS ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; ENDOCRINE GLANDS ; ENDOCRINE SYSTEM ; Estrogens - blood ; Female ; FEMALES ; FEMELLE ; GLANDE ENDOCRINE ; GLANDULAS ENDOCRINAS ; HEALTH ; HEALTH HAZARDS ; HEMBRA ; MACACA MULATTA ; Medical sciences ; Menstruation - drug effects ; MONKEYS ; MONO ; PERFORMANCE DE REPRODUCTION ; POLLUTION ; POLUCION ; POLYCHLORINATED BIPHENYLS ; Polychlorinated Biphenyls - toxicity ; POLYCHLORURE DE BIPHENYLE ; Progesterone - blood ; REPRODUCTIVE PERFORMANCE ; REPRODUCTIVIDAD ; SALUD ; SANTE ; SINGE ; Toxicology ; TREATMENT ; Various organic compounds</subject><ispartof>Archives of environmental contamination and toxicology, 1990-11, Vol.19 (6), p.939-943</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-e3cbcc5169a8240070a6525188630c22055ebd63ad2d187f372990dfddb96aa83</citedby><cites>FETCH-LOGICAL-c362t-e3cbcc5169a8240070a6525188630c22055ebd63ad2d187f372990dfddb96aa83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19427137$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2124092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Truelove, J.F. (Health and Welfare Canada, Ottawa, Ontario, Canada)</creatorcontrib><creatorcontrib>Tanner, J.R</creatorcontrib><creatorcontrib>Langlois, I.A</creatorcontrib><creatorcontrib>Stapley, R.A</creatorcontrib><creatorcontrib>Arnold, D.L</creatorcontrib><creatorcontrib>Mes, J.C</creatorcontrib><title>Effect of polychlorinated biphenyls on several endocrine reproductive parameters in the female rhesus monkey</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><description>Female rhesus monkeys (Macaca mulatta) ingested gelatin capsules containing daily doses of 0 (control), 5, 20, 40, or 80 micrograms of Aroclor 1254/kg/day (PCB) which was dissolved in corn oil plus glycerol. After approximately two years of dosing and when the monkeys were near an adipose tissue PCBs equilibrium, each dose group of 16 animals was randomly divided into two test groups. Daily blood samples from both groups were acquired for estrogen and progesterone analysis during one menstrual cycle. Test group 1 was sampled during February-March and test group 2 during August-September. Serum estrogen and progesterone concentrations in monkeys dosed with PCBs were equivalent to control values with the exception of the luteal phase progesterone levels in the 20 and 80 micrograms/kg/day dosed monkeys in test group 1. There was no difference in menstrual cycle length between control and treated monkeys for the month sampled, however, menses duration was marginally longer in the 80 micrograms/kg/day dose group. There were no apparent treatment related differences in the incidence of anovulatory cycles nor on the temporal relationship between the estrogen peak and menses onset, menses end or the progesterone peak.</description><subject>Animals</subject><subject>BIFENILOS POLICLORADOS</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>ENDOCRINE GLANDS</subject><subject>ENDOCRINE SYSTEM</subject><subject>Estrogens - blood</subject><subject>Female</subject><subject>FEMALES</subject><subject>FEMELLE</subject><subject>GLANDE ENDOCRINE</subject><subject>GLANDULAS ENDOCRINAS</subject><subject>HEALTH</subject><subject>HEALTH HAZARDS</subject><subject>HEMBRA</subject><subject>MACACA MULATTA</subject><subject>Medical sciences</subject><subject>Menstruation - drug effects</subject><subject>MONKEYS</subject><subject>MONO</subject><subject>PERFORMANCE DE REPRODUCTION</subject><subject>POLLUTION</subject><subject>POLUCION</subject><subject>POLYCHLORINATED BIPHENYLS</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>POLYCHLORURE DE BIPHENYLE</subject><subject>Progesterone - blood</subject><subject>REPRODUCTIVE PERFORMANCE</subject><subject>REPRODUCTIVIDAD</subject><subject>SALUD</subject><subject>SANTE</subject><subject>SINGE</subject><subject>Toxicology</subject><subject>TREATMENT</subject><subject>Various organic compounds</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1P3DAQBmALFcGWcumxEpIv9FAp7djOl48tghYJqQfgHE3scTfFiVM7Qdp_j6tdwcmHefR65mXso4CvAqD59uMGBFQV1NUR24hSyQIaUO_YBkBDUapSnLL3Kf0FELJtyxN2IoUsQcsN89fOkVl4cHwOfme2PsRhwoUs74d5S9POJx4mnuiZInpOkw0mC-KR5hjsapbhmfiMEUdaKCY-THzZEnc0os9qS2lNfAzTE-0-sGOHPtH54T1jjzfXD1e_irvfP2-vvt8VRtVyKUiZ3phK1BrbvGa-BetKVqJtawVGynwq9bZWaKUVbeNUI7UG66ztdY3YqjP2eZ-bN_y3Ulq6cUiGvMeJwpo6UcqmLpXO8MsemhhSiuS6OQ4jxl0noPtfbfdWbcYXh9S1H8m-0kOXeX55mGMy6F3EyQzpLVHnX4Vqsvu0dw5Dh39iNo_3WkAjVaVeANkziYg</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Truelove, J.F. 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(Health and Welfare Canada, Ottawa, Ontario, Canada) ; Tanner, J.R ; Langlois, I.A ; Stapley, R.A ; Arnold, D.L ; Mes, J.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-e3cbcc5169a8240070a6525188630c22055ebd63ad2d187f372990dfddb96aa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>BIFENILOS POLICLORADOS</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>ENDOCRINE GLANDS</topic><topic>ENDOCRINE SYSTEM</topic><topic>Estrogens - blood</topic><topic>Female</topic><topic>FEMALES</topic><topic>FEMELLE</topic><topic>GLANDE ENDOCRINE</topic><topic>GLANDULAS ENDOCRINAS</topic><topic>HEALTH</topic><topic>HEALTH HAZARDS</topic><topic>HEMBRA</topic><topic>MACACA MULATTA</topic><topic>Medical sciences</topic><topic>Menstruation - drug effects</topic><topic>MONKEYS</topic><topic>MONO</topic><topic>PERFORMANCE DE REPRODUCTION</topic><topic>POLLUTION</topic><topic>POLUCION</topic><topic>POLYCHLORINATED BIPHENYLS</topic><topic>Polychlorinated Biphenyls - toxicity</topic><topic>POLYCHLORURE DE BIPHENYLE</topic><topic>Progesterone - blood</topic><topic>REPRODUCTIVE PERFORMANCE</topic><topic>REPRODUCTIVIDAD</topic><topic>SALUD</topic><topic>SANTE</topic><topic>SINGE</topic><topic>Toxicology</topic><topic>TREATMENT</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Truelove, J.F. (Health and Welfare Canada, Ottawa, Ontario, Canada)</creatorcontrib><creatorcontrib>Tanner, J.R</creatorcontrib><creatorcontrib>Langlois, I.A</creatorcontrib><creatorcontrib>Stapley, R.A</creatorcontrib><creatorcontrib>Arnold, D.L</creatorcontrib><creatorcontrib>Mes, J.C</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Archives of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Truelove, J.F. (Health and Welfare Canada, Ottawa, Ontario, Canada)</au><au>Tanner, J.R</au><au>Langlois, I.A</au><au>Stapley, R.A</au><au>Arnold, D.L</au><au>Mes, J.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of polychlorinated biphenyls on several endocrine reproductive parameters in the female rhesus monkey</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>19</volume><issue>6</issue><spage>939</spage><epage>943</epage><pages>939-943</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>Female rhesus monkeys (Macaca mulatta) ingested gelatin capsules containing daily doses of 0 (control), 5, 20, 40, or 80 micrograms of Aroclor 1254/kg/day (PCB) which was dissolved in corn oil plus glycerol. After approximately two years of dosing and when the monkeys were near an adipose tissue PCBs equilibrium, each dose group of 16 animals was randomly divided into two test groups. Daily blood samples from both groups were acquired for estrogen and progesterone analysis during one menstrual cycle. Test group 1 was sampled during February-March and test group 2 during August-September. Serum estrogen and progesterone concentrations in monkeys dosed with PCBs were equivalent to control values with the exception of the luteal phase progesterone levels in the 20 and 80 micrograms/kg/day dosed monkeys in test group 1. There was no difference in menstrual cycle length between control and treated monkeys for the month sampled, however, menses duration was marginally longer in the 80 micrograms/kg/day dose group. There were no apparent treatment related differences in the incidence of anovulatory cycles nor on the temporal relationship between the estrogen peak and menses onset, menses end or the progesterone peak.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>2124092</pmid><doi>10.1007/BF01055065</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archives of environmental contamination and toxicology, 1990-11, Vol.19 (6), p.939-943 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals BIFENILOS POLICLORADOS Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases ENDOCRINE GLANDS ENDOCRINE SYSTEM Estrogens - blood Female FEMALES FEMELLE GLANDE ENDOCRINE GLANDULAS ENDOCRINAS HEALTH HEALTH HAZARDS HEMBRA MACACA MULATTA Medical sciences Menstruation - drug effects MONKEYS MONO PERFORMANCE DE REPRODUCTION POLLUTION POLUCION POLYCHLORINATED BIPHENYLS Polychlorinated Biphenyls - toxicity POLYCHLORURE DE BIPHENYLE Progesterone - blood REPRODUCTIVE PERFORMANCE REPRODUCTIVIDAD SALUD SANTE SINGE Toxicology TREATMENT Various organic compounds |
| title | Effect of polychlorinated biphenyls on several endocrine reproductive parameters in the female rhesus monkey |
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