Effects of 6-hydroxydopamine-induced catecholamine depletion on shock-precipitated wall climbing of infant rat pups
Sprague‐Dawley rat pups were intracisternally injected with 6‐hydroxydopamine (6OHDA) or vehicle on postnatal Day 3 and tested for footshock‐precipitated wall climbing behavior every 48 hr from postnatal Days 5 through 17. The 6OHDA treatment was observed to lower brain catecholamine levels, particu...
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| Veröffentlicht in: | Developmental psychobiology 1985-05, Vol.18 (3), p.215-227 |
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| container_title | Developmental psychobiology |
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| creator | Emerich, Dwaine F. Scalzo, Frank M. Enters, E. Karl Spear, Norman E. Spear, Linda Patia |
| description | Sprague‐Dawley rat pups were intracisternally injected with 6‐hydroxydopamine (6OHDA) or vehicle on postnatal Day 3 and tested for footshock‐precipitated wall climbing behavior every 48 hr from postnatal Days 5 through 17. The 6OHDA treatment was observed to lower brain catecholamine levels, particularly in forebrain, and to decrease the incidence of wall climbing. This attenuation in the amount of wall climbing did not appear to be related to any neurotoxin‐induced alterations in general motor activity, body weight, or body temperature. It also did not appear that the depression in wall climbing seen in 6OHDA‐treated animals was related to an observed neurotoxin‐induced increase in shock sensitivity, given that amount of wall climbing was observed to be positively correlated with footshock intensity. These results provide further support that catecholaminergic systems are involved in the elicitation of wall climbing behavior. The 6OHDA treatment did not alter the ontogenetic time course of disappearance of this behavior pattern, suggesting that maturational changes occurring in forebrain catecholaminergic terminals may not be critical for the dissipation of wall climbing following the second postnatal week. |
| doi_str_mv | 10.1002/dev.420180303 |
| format | Article |
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Karl ; Spear, Norman E. ; Spear, Linda Patia</creator><creatorcontrib>Emerich, Dwaine F. ; Scalzo, Frank M. ; Enters, E. Karl ; Spear, Norman E. ; Spear, Linda Patia</creatorcontrib><description>Sprague‐Dawley rat pups were intracisternally injected with 6‐hydroxydopamine (6OHDA) or vehicle on postnatal Day 3 and tested for footshock‐precipitated wall climbing behavior every 48 hr from postnatal Days 5 through 17. The 6OHDA treatment was observed to lower brain catecholamine levels, particularly in forebrain, and to decrease the incidence of wall climbing. This attenuation in the amount of wall climbing did not appear to be related to any neurotoxin‐induced alterations in general motor activity, body weight, or body temperature. It also did not appear that the depression in wall climbing seen in 6OHDA‐treated animals was related to an observed neurotoxin‐induced increase in shock sensitivity, given that amount of wall climbing was observed to be positively correlated with footshock intensity. These results provide further support that catecholaminergic systems are involved in the elicitation of wall climbing behavior. The 6OHDA treatment did not alter the ontogenetic time course of disappearance of this behavior pattern, suggesting that maturational changes occurring in forebrain catecholaminergic terminals may not be critical for the dissipation of wall climbing following the second postnatal week.</description><identifier>ISSN: 0012-1630</identifier><identifier>EISSN: 1098-2302</identifier><identifier>DOI: 10.1002/dev.420180303</identifier><identifier>PMID: 3921418</identifier><identifier>CODEN: DEPBA5</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Animals, Suckling ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Body Temperature - drug effects ; Body Weight - drug effects ; Brain Chemistry - drug effects ; Dopamine - analysis ; Dopamine - metabolism ; Electroshock ; Fundamental and applied biological sciences. 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Karl</creatorcontrib><creatorcontrib>Spear, Norman E.</creatorcontrib><creatorcontrib>Spear, Linda Patia</creatorcontrib><title>Effects of 6-hydroxydopamine-induced catecholamine depletion on shock-precipitated wall climbing of infant rat pups</title><title>Developmental psychobiology</title><addtitle>Dev. Psychobiol</addtitle><description>Sprague‐Dawley rat pups were intracisternally injected with 6‐hydroxydopamine (6OHDA) or vehicle on postnatal Day 3 and tested for footshock‐precipitated wall climbing behavior every 48 hr from postnatal Days 5 through 17. The 6OHDA treatment was observed to lower brain catecholamine levels, particularly in forebrain, and to decrease the incidence of wall climbing. This attenuation in the amount of wall climbing did not appear to be related to any neurotoxin‐induced alterations in general motor activity, body weight, or body temperature. It also did not appear that the depression in wall climbing seen in 6OHDA‐treated animals was related to an observed neurotoxin‐induced increase in shock sensitivity, given that amount of wall climbing was observed to be positively correlated with footshock intensity. These results provide further support that catecholaminergic systems are involved in the elicitation of wall climbing behavior. The 6OHDA treatment did not alter the ontogenetic time course of disappearance of this behavior pattern, suggesting that maturational changes occurring in forebrain catecholaminergic terminals may not be critical for the dissipation of wall climbing following the second postnatal week.</description><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Brain Chemistry - drug effects</subject><subject>Dopamine - analysis</subject><subject>Dopamine - metabolism</subject><subject>Electroshock</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydroxydopamines - pharmacology</subject><subject>Motor Activity - drug effects</subject><subject>Norepinephrine - analysis</subject><subject>Norepinephrine - metabolism</subject><subject>Oxidopamine</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0012-1630</issn><issn>1098-2302</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EKkvLkSNSDohbih07cXJEZdtFrShCBY6WPR6zps5H7YR2_z0pG604VRppNDPPvDN6CXnD6CmjtPhg8c-pKCirKaf8GVkx2tR5wWnxnKwoZUXOKk5fklcp_Z5LJmp5RI54UzDB6hVJa-cQxpT1Lqvy7c7G_mFn-0G3vsPcd3YCtBnoEWHbh3_dzOIQcPR9l82Rtj3c5kNE8IMfZ85m9zqEDIJvje9-PQr7zuluzKIes2Ea0gl54XRI-HrJx-T7-frmbJNfXV98Pvt4lYPggueFKKGy1lFDnZbQlBaMrLEutQFrGlo2WFHpaA1YgRC8Fhw1GGM4K42VyI_J-73uEPu7CdOoWp8AQ9Ad9lNSTBSyFJLPYL4HIfYpRXRqiL7VcacYVY8mq9lkdTB55t8uwpNp0R7oxdV5_m6Z6wQ6uKg78OmA1bKRVFQzJvfYvQ-4e_qm-rT-8f8Dy8M-jfhw2NTxVlWSy1L9_HKhLvnlZnP-9Zuq-F_btqaR</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Emerich, Dwaine F.</creator><creator>Scalzo, Frank M.</creator><creator>Enters, E. 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| ispartof | Developmental psychobiology, 1985-05, Vol.18 (3), p.215-227 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Animals, Suckling Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Body Temperature - drug effects Body Weight - drug effects Brain Chemistry - drug effects Dopamine - analysis Dopamine - metabolism Electroshock Fundamental and applied biological sciences. Psychology Hydroxydopamines - pharmacology Motor Activity - drug effects Norepinephrine - analysis Norepinephrine - metabolism Oxidopamine Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains |
| title | Effects of 6-hydroxydopamine-induced catecholamine depletion on shock-precipitated wall climbing of infant rat pups |
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