Lysinoalanine: Absence of mutagenic response in the salmonella/mammalian-microsome mutagenicity assay
Lysinoalanine ( N ϵ -( dl-2-amino-2-carboxyethyl)- l-lysine) was tested for mutagenicity in the Ames Salmonella/mammalian-microsome mutagenicity assay. No mutagenic response was detected at doses up to 5 mg/plate when samples were pre-incubated without S-9 mix, nor when they were pre-incubuted with...
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| Veröffentlicht in: | Food and chemical toxicology 1985-01, Vol.23 (8), p.763-765 |
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| container_title | Food and chemical toxicology |
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| creator | Pintauro, S.J. Philippossian, G. Finot, P.A. Lee, T.-C. |
| description | Lysinoalanine (
N
ϵ
-(
dl-2-amino-2-carboxyethyl)-
l-lysine) was tested for mutagenicity in the Ames Salmonella/mammalian-microsome mutagenicity assay. No mutagenic response was detected at doses up to 5 mg/plate when samples were pre-incubated without S-9 mix, nor when they were pre-incubuted with S-9 mix prepared from Aroclor 1254-induced rat liver or kidney. The results indicate that the stereoisomers of lysinoalanine likely to be present in the greatest proportions in processed foods are not mutagenic in the Ames assay. |
| doi_str_mv | 10.1016/0278-6915(85)90272-8 |
| format | Article |
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N
ϵ
-(
dl-2-amino-2-carboxyethyl)-
l-lysine) was tested for mutagenicity in the Ames Salmonella/mammalian-microsome mutagenicity assay. No mutagenic response was detected at doses up to 5 mg/plate when samples were pre-incubated without S-9 mix, nor when they were pre-incubuted with S-9 mix prepared from Aroclor 1254-induced rat liver or kidney. The results indicate that the stereoisomers of lysinoalanine likely to be present in the greatest proportions in processed foods are not mutagenic in the Ames assay.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/0278-6915(85)90272-8</identifier><identifier>PMID: 3930353</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Food industries ; Food toxicology ; foods ; Fundamental and applied biological sciences. Psychology ; Kidney Tubules - drug effects ; Lysine - analogs & derivatives ; lysinoalanine ; Lysinoalanine - toxicity ; Microsomes - drug effects ; Microsomes - metabolism ; Mutagenicity Tests ; Mutagens - metabolism ; Rats ; Salmonella - drug effects ; Stereoisomerism ; toxicology</subject><ispartof>Food and chemical toxicology, 1985-01, Vol.23 (8), p.763-765</ispartof><rights>1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-ac98311aff6bbdbd7219fdbf46cd144d1183256ef43d91baa0ccce02e42f61b93</citedby><cites>FETCH-LOGICAL-c441t-ac98311aff6bbdbd7219fdbf46cd144d1183256ef43d91baa0ccce02e42f61b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0278691585902728$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9223692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3930353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pintauro, S.J.</creatorcontrib><creatorcontrib>Philippossian, G.</creatorcontrib><creatorcontrib>Finot, P.A.</creatorcontrib><creatorcontrib>Lee, T.-C.</creatorcontrib><title>Lysinoalanine: Absence of mutagenic response in the salmonella/mammalian-microsome mutagenicity assay</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Lysinoalanine (
N
ϵ
-(
dl-2-amino-2-carboxyethyl)-
l-lysine) was tested for mutagenicity in the Ames Salmonella/mammalian-microsome mutagenicity assay. No mutagenic response was detected at doses up to 5 mg/plate when samples were pre-incubated without S-9 mix, nor when they were pre-incubuted with S-9 mix prepared from Aroclor 1254-induced rat liver or kidney. The results indicate that the stereoisomers of lysinoalanine likely to be present in the greatest proportions in processed foods are not mutagenic in the Ames assay.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Food industries</subject><subject>Food toxicology</subject><subject>foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kidney Tubules - drug effects</subject><subject>Lysine - analogs & derivatives</subject><subject>lysinoalanine</subject><subject>Lysinoalanine - toxicity</subject><subject>Microsomes - drug effects</subject><subject>Microsomes - metabolism</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - metabolism</subject><subject>Rats</subject><subject>Salmonella - drug effects</subject><subject>Stereoisomerism</subject><subject>toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo67j6DxT7IKKHdlNJ-iN7EJbFLxjwoHsO1enKGukkY9IjzL-32xnGm6cQ6nmLl6cYew78HXBor7jo-rrV0Lzpm7d6-Ym6f8A20HeybmUDD9nmjDxmT0r5yTnvoGsv2IXUkstGbhhtD8XHhBNGH-m6uhkKRUtVclXYz3hP0dsqU9mlWKjysZp_UFVwCinSNOFVwBBw8hjr4G1OJQX6F_TzocJS8PCUPXI4FXp2ei_Z3ccP328_19uvn77c3mxrqxTMNVrdSwB0rh2GcRg7AdqNg1OtHUGpEaCXomnJKTlqGBC5tZa4ICVcC4OWl-z1ce8up197KrMJvti1aKS0LwaU6EDzFVRHcO1cMjmzyz5gPhjgZrVrVnVmVWf6xvy1a_ol9uK0fz8EGs-hk85l_uo0x2Jxchmj9eWMaSFkq8WCvTxiDpPB-7wgd98EB8lBNU0v137vjwQttn57yqZYvx5m9JnsbMbk_9_0D4CpoZ8</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Pintauro, S.J.</creator><creator>Philippossian, G.</creator><creator>Finot, P.A.</creator><creator>Lee, T.-C.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19850101</creationdate><title>Lysinoalanine: Absence of mutagenic response in the salmonella/mammalian-microsome mutagenicity assay</title><author>Pintauro, S.J. ; Philippossian, G. ; Finot, P.A. ; Lee, T.-C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-ac98311aff6bbdbd7219fdbf46cd144d1183256ef43d91baa0ccce02e42f61b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Food industries</topic><topic>Food toxicology</topic><topic>foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kidney Tubules - drug effects</topic><topic>Lysine - analogs & derivatives</topic><topic>lysinoalanine</topic><topic>Lysinoalanine - toxicity</topic><topic>Microsomes - drug effects</topic><topic>Microsomes - metabolism</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - metabolism</topic><topic>Rats</topic><topic>Salmonella - drug effects</topic><topic>Stereoisomerism</topic><topic>toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pintauro, S.J.</creatorcontrib><creatorcontrib>Philippossian, G.</creatorcontrib><creatorcontrib>Finot, P.A.</creatorcontrib><creatorcontrib>Lee, T.-C.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pintauro, S.J.</au><au>Philippossian, G.</au><au>Finot, P.A.</au><au>Lee, T.-C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lysinoalanine: Absence of mutagenic response in the salmonella/mammalian-microsome mutagenicity assay</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>23</volume><issue>8</issue><spage>763</spage><epage>765</epage><pages>763-765</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Lysinoalanine (
N
ϵ
-(
dl-2-amino-2-carboxyethyl)-
l-lysine) was tested for mutagenicity in the Ames Salmonella/mammalian-microsome mutagenicity assay. No mutagenic response was detected at doses up to 5 mg/plate when samples were pre-incubated without S-9 mix, nor when they were pre-incubuted with S-9 mix prepared from Aroclor 1254-induced rat liver or kidney. The results indicate that the stereoisomers of lysinoalanine likely to be present in the greatest proportions in processed foods are not mutagenic in the Ames assay.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3930353</pmid><doi>10.1016/0278-6915(85)90272-8</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 1985-01, Vol.23 (8), p.763-765 |
| issn | 0278-6915 1873-6351 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Food industries Food toxicology foods Fundamental and applied biological sciences. Psychology Kidney Tubules - drug effects Lysine - analogs & derivatives lysinoalanine Lysinoalanine - toxicity Microsomes - drug effects Microsomes - metabolism Mutagenicity Tests Mutagens - metabolism Rats Salmonella - drug effects Stereoisomerism toxicology |
| title | Lysinoalanine: Absence of mutagenic response in the salmonella/mammalian-microsome mutagenicity assay |
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