Age-related changes of blood-oxygen-leveladependent signal dynamics during optokinetic stimulation

Age-related changes of blood-oxygen-leveladependent signal dynamics during optokinetic stimulation

The present study aimed to reveal the effects of age on the temporal profile of the positive blood-oxygen-leveladependent response (PBR) during low-velocity optokinetic nystagmus (OKN) in healthy subjects. We were specifically interested in comparing these effects with the effects of age on the PBR...

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Veröffentlicht in:Neurobiology of aging 2013-10, Vol.34 (10), p.2277-2286
Hauptverfasser: Stefanova, Iskra, Stephan, Thomas, Becker-Bense, Sandra, Dera, Thomas, Brandt, Thomas, Dieterich, Marianne
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container_issue 10
container_start_page 2277
container_title Neurobiology of aging
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creator Stefanova, Iskra
Stephan, Thomas
Becker-Bense, Sandra
Dera, Thomas
Brandt, Thomas
Dieterich, Marianne
description The present study aimed to reveal the effects of age on the temporal profile of the positive blood-oxygen-leveladependent response (PBR) during low-velocity optokinetic nystagmus (OKN) in healthy subjects. We were specifically interested in comparing these effects with the effects of age on the PBR elicited by pure visual and motor tasks. Therefore, we conducted 2 additional control experiments: a checkerboard experiment (visual stimulation) and a finger-tapping (motor task) experiment. Whereas the oculomotor performance of the subjects remained unaltered, the temporal profile of the PBR changed significantly with increasing age in visual and oculomotor areas. None of the control experiments revealed significant age-related PBR changes. Thus, this study demonstrates that the PBR changes during OKN occur before any changes in the oculomotor performance can be detected. These effects of age are specific for the OKN task and probably reflect both changes in the neurovascular coupling and changes in the neural processing during OKN.
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