Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk
Macrophages develop into specialized cell types with special functional properties, depending on locally produced stimuli. Adipose tissue macrophages present particular characteristics, such as the M2 cell phenotype, and produce cytokines and chemokines usually produced by M1 cells. Our aim was to s...
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| Veröffentlicht in: | In vitro cellular & developmental biology. Animal 2013-06, Vol.49 (6), p.473-478 |
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| creator | Acedo, Simone Coghetto Gambero, Sheley Cunha, Fernanda Gonçalves Pereira Lorand-Metze, Irene Gambero, Alessandra |
| description | Macrophages develop into specialized cell types with special functional properties, depending on locally produced stimuli. Adipose tissue macrophages present particular characteristics, such as the M2 cell phenotype, and produce cytokines and chemokines usually produced by M1 cells. Our aim was to study the role of leptin, which is an adipokine produced and released by adipocytes, in the induction of these characteristics in macrophages found in the adipose tissue. Human CD14⁺ cells were obtained and maintained in culture with IFN-γ (classical M1 phenotype), IL-4 (alternative M2 phenotype) or leptin for 5 d. Surface marker expression was then analyzed by cytometry. In addition, the release of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, IL-10, IL-1ra, MCP-1, MIP-1α, and RANTES was quantified by ELISA after an LPS stimulus, in the culture supernatant. Macrophages exposed to leptin in culture expressed surface markers that were more similar to the M2 phenotype, but they were able to produce TNF-α, IL-6, IL-1β, IL-1ra, IL-10, MCP-1, and MIP-1α, as observed for M1 cells. Results suggest that leptin strongly contributes to the phenotype observed in macrophages found in adipose tissue. |
| doi_str_mv | 10.1007/s11626-013-9629-x |
| format | Article |
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Adipose tissue macrophages present particular characteristics, such as the M2 cell phenotype, and produce cytokines and chemokines usually produced by M1 cells. Our aim was to study the role of leptin, which is an adipokine produced and released by adipocytes, in the induction of these characteristics in macrophages found in the adipose tissue. Human CD14⁺ cells were obtained and maintained in culture with IFN-γ (classical M1 phenotype), IL-4 (alternative M2 phenotype) or leptin for 5 d. Surface marker expression was then analyzed by cytometry. In addition, the release of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, IL-10, IL-1ra, MCP-1, MIP-1α, and RANTES was quantified by ELISA after an LPS stimulus, in the culture supernatant. Macrophages exposed to leptin in culture expressed surface markers that were more similar to the M2 phenotype, but they were able to produce TNF-α, IL-6, IL-1β, IL-1ra, IL-10, MCP-1, and MIP-1α, as observed for M1 cells. Results suggest that leptin strongly contributes to the phenotype observed in macrophages found in adipose tissue.</description><identifier>ISSN: 1071-2690</identifier><identifier>EISSN: 1543-706X</identifier><identifier>DOI: 10.1007/s11626-013-9629-x</identifier><identifier>PMID: 23708919</identifier><identifier>CODEN: IVCAED</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adipocytes ; Adipocytes - cytology ; Adipocytes - drug effects ; Adipocytes - metabolism ; adipose tissue ; Adipose tissues ; Animal Genetics and Genomics ; Biomedical and Life Sciences ; Cell Biology ; Cell Culture ; CELL GROWTH/DIFFERENTIATION/APOPTOSIS ; Chemokines ; Cytokines ; Developmental Biology ; enzyme-linked immunosorbent assay ; Gene Expression Regulation - drug effects ; Humans ; interferon-gamma ; Interleukin-1 - metabolism ; interleukin-10 ; Interleukin-10 - metabolism ; interleukin-1beta ; interleukin-4 ; Interleukin-4 - metabolism ; interleukin-6 ; Interleukin-6 - metabolism ; leptin ; Leptin - pharmacology ; Life Sciences ; Lipopolysaccharide Receptors - metabolism ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Mice ; Monocytes ; Obesity ; phenotype ; Phenotypes ; Receptors ; Stem Cells ; tumor necrosis factor-alpha ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>In vitro cellular & developmental biology. Animal, 2013-06, Vol.49 (6), p.473-478</ispartof><rights>2013 Society for In Vitro Biology</rights><rights>The Society for In Vitro Biology 2013</rights><rights>Copyright Society for In Vitro Biology Jun 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-ba2028c4f1f37fa808b25aa948fef359c482ef2ecafcd905fe206154b6e81923</citedby><cites>FETCH-LOGICAL-c517t-ba2028c4f1f37fa808b25aa948fef359c482ef2ecafcd905fe206154b6e81923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23481787$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23481787$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,41488,42557,51319,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23708919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Acedo, Simone Coghetto</creatorcontrib><creatorcontrib>Gambero, Sheley</creatorcontrib><creatorcontrib>Cunha, Fernanda Gonçalves Pereira</creatorcontrib><creatorcontrib>Lorand-Metze, Irene</creatorcontrib><creatorcontrib>Gambero, Alessandra</creatorcontrib><title>Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell.Dev.Biol.-Animal</addtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>Macrophages develop into specialized cell types with special functional properties, depending on locally produced stimuli. Adipose tissue macrophages present particular characteristics, such as the M2 cell phenotype, and produce cytokines and chemokines usually produced by M1 cells. Our aim was to study the role of leptin, which is an adipokine produced and released by adipocytes, in the induction of these characteristics in macrophages found in the adipose tissue. Human CD14⁺ cells were obtained and maintained in culture with IFN-γ (classical M1 phenotype), IL-4 (alternative M2 phenotype) or leptin for 5 d. Surface marker expression was then analyzed by cytometry. In addition, the release of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, IL-10, IL-1ra, MCP-1, MIP-1α, and RANTES was quantified by ELISA after an LPS stimulus, in the culture supernatant. Macrophages exposed to leptin in culture expressed surface markers that were more similar to the M2 phenotype, but they were able to produce TNF-α, IL-6, IL-1β, IL-1ra, IL-10, MCP-1, and MIP-1α, as observed for M1 cells. Results suggest that leptin strongly contributes to the phenotype observed in macrophages found in adipose tissue.</description><subject>Adipocytes</subject><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>adipose tissue</subject><subject>Adipose tissues</subject><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>CELL GROWTH/DIFFERENTIATION/APOPTOSIS</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Developmental Biology</subject><subject>enzyme-linked immunosorbent assay</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>interferon-gamma</subject><subject>Interleukin-1 - metabolism</subject><subject>interleukin-10</subject><subject>Interleukin-10 - metabolism</subject><subject>interleukin-1beta</subject><subject>interleukin-4</subject><subject>Interleukin-4 - metabolism</subject><subject>interleukin-6</subject><subject>Interleukin-6 - metabolism</subject><subject>leptin</subject><subject>Leptin - pharmacology</subject><subject>Life Sciences</subject><subject>Lipopolysaccharide Receptors - metabolism</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Monocytes</subject><subject>Obesity</subject><subject>phenotype</subject><subject>Phenotypes</subject><subject>Receptors</subject><subject>Stem Cells</subject><subject>tumor necrosis factor-alpha</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1071-2690</issn><issn>1543-706X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9v1DAQxSNERf_AB-AAROLCJTB2EsfmhioKlSqBRJG4WbPJeNdLEqe2V-pe-8nrkFKtOGBZ8sjvN8_yvCx7yeA9A2g-BMYEFwWwslCCq-L2SXbC6qosGhC_nqYaGlZwoeA4Ow1hC2kpJp5lx7xsQCqmTrK77-ijbe2E0boxdybvaYp2zNOOG8o7iuQHOz7K8-WArXfTBteUTxsaXdxP9DHHMceuszOIfe5dT7MJdnZy7T5S0rvDzlSEELH__Tw7MtgHevFwnmXXF5-vz78WV9--XJ5_uiramjWxWCEHLtvKMFM2BiXIFa8RVSUNmbJWbSU5GU4tmrZTUBviINI0VoIkU7w8y94ttpN3NzsKUQ82tNT3OJLbBc0q3qShMgkJffsPunU7n341U1U9z1HUiWIL9ecnnoyevB3Q7zUDPeejl3x0ykfP-ejb1PP6wXm3Gqh77PgbSAL4AoQkjWvyB0__x_XV0rQN0fkD00qyRjZJf7PoBp3GtbdB__zBgVUATNTAeXkPSbiwZQ</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Acedo, Simone Coghetto</creator><creator>Gambero, Sheley</creator><creator>Cunha, Fernanda Gonçalves Pereira</creator><creator>Lorand-Metze, Irene</creator><creator>Gambero, Alessandra</creator><general>Springer-Verlag</general><general>Springer Science + Business Media</general><general>Society for In Vitro Biology</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7QO</scope></search><sort><creationdate>20130601</creationdate><title>Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk</title><author>Acedo, Simone Coghetto ; Gambero, Sheley ; Cunha, Fernanda Gonçalves Pereira ; Lorand-Metze, Irene ; Gambero, Alessandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-ba2028c4f1f37fa808b25aa948fef359c482ef2ecafcd905fe206154b6e81923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipocytes</topic><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>adipose tissue</topic><topic>Adipose tissues</topic><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>CELL GROWTH/DIFFERENTIATION/APOPTOSIS</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Developmental Biology</topic><topic>enzyme-linked immunosorbent assay</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Humans</topic><topic>interferon-gamma</topic><topic>Interleukin-1 - metabolism</topic><topic>interleukin-10</topic><topic>Interleukin-10 - metabolism</topic><topic>interleukin-1beta</topic><topic>interleukin-4</topic><topic>Interleukin-4 - metabolism</topic><topic>interleukin-6</topic><topic>Interleukin-6 - metabolism</topic><topic>leptin</topic><topic>Leptin - pharmacology</topic><topic>Life Sciences</topic><topic>Lipopolysaccharide Receptors - metabolism</topic><topic>Macrophages</topic><topic>Macrophages - 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Animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acedo, Simone Coghetto</au><au>Gambero, Sheley</au><au>Cunha, Fernanda Gonçalves Pereira</au><au>Lorand-Metze, Irene</au><au>Gambero, Alessandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk</atitle><jtitle>In vitro cellular & developmental biology. Animal</jtitle><stitle>In Vitro Cell.Dev.Biol.-Animal</stitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>49</volume><issue>6</issue><spage>473</spage><epage>478</epage><pages>473-478</pages><issn>1071-2690</issn><eissn>1543-706X</eissn><coden>IVCAED</coden><abstract>Macrophages develop into specialized cell types with special functional properties, depending on locally produced stimuli. Adipose tissue macrophages present particular characteristics, such as the M2 cell phenotype, and produce cytokines and chemokines usually produced by M1 cells. Our aim was to study the role of leptin, which is an adipokine produced and released by adipocytes, in the induction of these characteristics in macrophages found in the adipose tissue. Human CD14⁺ cells were obtained and maintained in culture with IFN-γ (classical M1 phenotype), IL-4 (alternative M2 phenotype) or leptin for 5 d. Surface marker expression was then analyzed by cytometry. In addition, the release of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, IL-10, IL-1ra, MCP-1, MIP-1α, and RANTES was quantified by ELISA after an LPS stimulus, in the culture supernatant. Macrophages exposed to leptin in culture expressed surface markers that were more similar to the M2 phenotype, but they were able to produce TNF-α, IL-6, IL-1β, IL-1ra, IL-10, MCP-1, and MIP-1α, as observed for M1 cells. Results suggest that leptin strongly contributes to the phenotype observed in macrophages found in adipose tissue.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23708919</pmid><doi>10.1007/s11626-013-9629-x</doi><tpages>6</tpages></addata></record> |
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| ispartof | In vitro cellular & developmental biology. Animal, 2013-06, Vol.49 (6), p.473-478 |
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| subjects | Adipocytes Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism adipose tissue Adipose tissues Animal Genetics and Genomics Biomedical and Life Sciences Cell Biology Cell Culture CELL GROWTH/DIFFERENTIATION/APOPTOSIS Chemokines Cytokines Developmental Biology enzyme-linked immunosorbent assay Gene Expression Regulation - drug effects Humans interferon-gamma Interleukin-1 - metabolism interleukin-10 Interleukin-10 - metabolism interleukin-1beta interleukin-4 Interleukin-4 - metabolism interleukin-6 Interleukin-6 - metabolism leptin Leptin - pharmacology Life Sciences Lipopolysaccharide Receptors - metabolism Macrophages Macrophages - drug effects Macrophages - metabolism Mice Monocytes Obesity phenotype Phenotypes Receptors Stem Cells tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - metabolism |
| title | Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk |
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