Phenotropil Succinate as a Substance Correcting Neuroimmune Impairments in Conditions of Informational-Physical Stress

The psychoimmunomodulatory properties of phenotropil succinate were studied in conditions of experimental informational-physical stress in Wistar rats. Stress was modeled by alternation of two loads: physical (swimming with a load of 10% of body weight as long as could be tolerated) and informational (formation of a food-procuring behavior in a multiple-choice maze) for 20 days. The effects of phenotropil succinate on the specific and nonspecific resistance of the body were studied. Changes in the animals’ psychoemotional status during exposure to phenotropil succinate were analyzed in the elevated plus maze test and the Porsolt test. The results provide evidence that courses of phenotropil succinate can eliminate neuroimmune impairments developing in conditions of informational-physical stress.