Longitudinal Oxygen Tension Gradients in Small Cortical Microvessels in the Rat Brain on Development of Acute Anemia
Oxygen microelectrodes were used to study longitudinal oxygen tension gradients (pO 2 ) in small arterioles (with lumen diameters in control conditions of 5–20 μm) and capillaries in the rat cerebral cortex during stepwise decreases in the blood hemoglobin concentration ([Hb]) from an initial 14.4 ±...
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| Veröffentlicht in: | Neuroscience and behavioral physiology 2013-07, Vol.43 (6), p.748-754 |
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| description | Oxygen microelectrodes were used to study longitudinal oxygen tension gradients (pO
2
) in small arterioles (with lumen diameters in control conditions of 5–20 μm) and capillaries in the rat cerebral cortex during stepwise decreases in the blood hemoglobin concentration ([Hb]) from an initial 14.4 ± 0.3 g/liter to 10.1 ± 0.2 (step 1), 7.0 ± 0.2 (step 2), and 3.7 ± 0.2 (step 3) g/liter. All data are presented as mean ± error of the mean. Oxygen tension was measured at two points in arteriole segments, separated from each other by distances of ΔL = 265 ± 34 μm,
n
= 30. The mean diameter of arteriole lumens in controls was 10.7 ± 0.5 μm,
n
= 71. The magnitude of the longitudinal pO
2
gradient (ΔpO
2
/ΔL) for the study arterioles was (mmHg/μm): 0.03 ± 0.01,
n
= 15 (controls), 0.06 ± 0.01,
n
= 16 (step 1), 0.07 ± 0.01,
n
= 14 (step 2), and 0.1 ± 0.01,
n
= 30 (step 3). In capillaries, ΔpO
2
/ΔL (with a segment length ΔL = 201 ± 45 μm,
n
= 18) was (mmHg/μm): 0.07 ± 0.01,
n
= 17 (controls), 0.09 ± 0.02,
n
= 16 (step 1), 0.08 ± 0.01,
n
= 15 (step 2), and 0.1 ± 0.02,
n
= 18 (step 3). The more than threefold decrease in oxygen content in arterial blood did not lead to significant changes (
p
> 0.05) in ΔpO
2
/ΔL in capillaries. Longitudinal hemoglobin oxygenation gradients (ΔSO
2
/ΔL) in capillaries (calculated using the animals' systemic blood oxyhemoglobin dissociation curve) was some three times greater than in arterioles, which provides evidence for the leading role of capillaries in supplying oxygen to the cerebral cortex in these conditions. These data include the first measurements of longitudinal pO
2
gradients in arterioles and capillaries in the cerebral cortex on development of acute anemia. |
| doi_str_mv | 10.1007/s11055-013-9804-2 |
| format | Article |
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2
) in small arterioles (with lumen diameters in control conditions of 5–20 μm) and capillaries in the rat cerebral cortex during stepwise decreases in the blood hemoglobin concentration ([Hb]) from an initial 14.4 ± 0.3 g/liter to 10.1 ± 0.2 (step 1), 7.0 ± 0.2 (step 2), and 3.7 ± 0.2 (step 3) g/liter. All data are presented as mean ± error of the mean. Oxygen tension was measured at two points in arteriole segments, separated from each other by distances of ΔL = 265 ± 34 μm,
n
= 30. The mean diameter of arteriole lumens in controls was 10.7 ± 0.5 μm,
n
= 71. The magnitude of the longitudinal pO
2
gradient (ΔpO
2
/ΔL) for the study arterioles was (mmHg/μm): 0.03 ± 0.01,
n
= 15 (controls), 0.06 ± 0.01,
n
= 16 (step 1), 0.07 ± 0.01,
n
= 14 (step 2), and 0.1 ± 0.01,
n
= 30 (step 3). In capillaries, ΔpO
2
/ΔL (with a segment length ΔL = 201 ± 45 μm,
n
= 18) was (mmHg/μm): 0.07 ± 0.01,
n
= 17 (controls), 0.09 ± 0.02,
n
= 16 (step 1), 0.08 ± 0.01,
n
= 15 (step 2), and 0.1 ± 0.02,
n
= 18 (step 3). The more than threefold decrease in oxygen content in arterial blood did not lead to significant changes (
p
> 0.05) in ΔpO
2
/ΔL in capillaries. Longitudinal hemoglobin oxygenation gradients (ΔSO
2
/ΔL) in capillaries (calculated using the animals' systemic blood oxyhemoglobin dissociation curve) was some three times greater than in arterioles, which provides evidence for the leading role of capillaries in supplying oxygen to the cerebral cortex in these conditions. These data include the first measurements of longitudinal pO
2
gradients in arterioles and capillaries in the cerebral cortex on development of acute anemia.</description><identifier>ISSN: 0097-0549</identifier><identifier>EISSN: 1573-899X</identifier><identifier>DOI: 10.1007/s11055-013-9804-2</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Anemia ; Behavioral Sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood vessels ; Electrodes ; Hemoglobin ; Hypoxia ; Neurobiology ; Neurosciences ; Physiology ; Veins & arteries</subject><ispartof>Neuroscience and behavioral physiology, 2013-07, Vol.43 (6), p.748-754</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2642-42eebd7388a29d69e5f49159037dfa31512a1f55b8ebdb3941d7da3e06317cf53</citedby><cites>FETCH-LOGICAL-c2642-42eebd7388a29d69e5f49159037dfa31512a1f55b8ebdb3941d7da3e06317cf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11055-013-9804-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11055-013-9804-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Vovenko, E. P.</creatorcontrib><creatorcontrib>Chuikin, A. E.</creatorcontrib><title>Longitudinal Oxygen Tension Gradients in Small Cortical Microvessels in the Rat Brain on Development of Acute Anemia</title><title>Neuroscience and behavioral physiology</title><addtitle>Neurosci Behav Physi</addtitle><description>Oxygen microelectrodes were used to study longitudinal oxygen tension gradients (pO
2
) in small arterioles (with lumen diameters in control conditions of 5–20 μm) and capillaries in the rat cerebral cortex during stepwise decreases in the blood hemoglobin concentration ([Hb]) from an initial 14.4 ± 0.3 g/liter to 10.1 ± 0.2 (step 1), 7.0 ± 0.2 (step 2), and 3.7 ± 0.2 (step 3) g/liter. All data are presented as mean ± error of the mean. Oxygen tension was measured at two points in arteriole segments, separated from each other by distances of ΔL = 265 ± 34 μm,
n
= 30. The mean diameter of arteriole lumens in controls was 10.7 ± 0.5 μm,
n
= 71. The magnitude of the longitudinal pO
2
gradient (ΔpO
2
/ΔL) for the study arterioles was (mmHg/μm): 0.03 ± 0.01,
n
= 15 (controls), 0.06 ± 0.01,
n
= 16 (step 1), 0.07 ± 0.01,
n
= 14 (step 2), and 0.1 ± 0.01,
n
= 30 (step 3). In capillaries, ΔpO
2
/ΔL (with a segment length ΔL = 201 ± 45 μm,
n
= 18) was (mmHg/μm): 0.07 ± 0.01,
n
= 17 (controls), 0.09 ± 0.02,
n
= 16 (step 1), 0.08 ± 0.01,
n
= 15 (step 2), and 0.1 ± 0.02,
n
= 18 (step 3). The more than threefold decrease in oxygen content in arterial blood did not lead to significant changes (
p
> 0.05) in ΔpO
2
/ΔL in capillaries. Longitudinal hemoglobin oxygenation gradients (ΔSO
2
/ΔL) in capillaries (calculated using the animals' systemic blood oxyhemoglobin dissociation curve) was some three times greater than in arterioles, which provides evidence for the leading role of capillaries in supplying oxygen to the cerebral cortex in these conditions. These data include the first measurements of longitudinal pO
2
gradients in arterioles and capillaries in the cerebral cortex on development of acute anemia.</description><subject>Anemia</subject><subject>Behavioral Sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood vessels</subject><subject>Electrodes</subject><subject>Hemoglobin</subject><subject>Hypoxia</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Physiology</subject><subject>Veins & arteries</subject><issn>0097-0549</issn><issn>1573-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1LJDEQhoOs4Kz6A7wFvHhprSSdSec4zu6qMCL4Ad5Cprt6jHQnY9It-u_NOB5kwVNR1PMUVL2EHDE4ZQDqLDEGUhbARKErKAu-QyZMKlFUWj_-IhMArQqQpd4jv1N6huyoCiZkWAS_csPYOG87evP2vkJP79EnFzy9iLZx6IdEnad3ve06Og9xcHVGr10dwyumhN3neHhCemsHeh5t7rL8B1-xC-s--zS0dFaPA9KZx97ZA7Lb2i7h4VfdJw___t7PL4vFzcXVfLYoaj4teVFyxGWjRFVZrpupRtmWmkkNQjWtFUwyblkr5bLK2FLokjWqsQJhKpiqWyn2ycl27zqGlxHTYHqXauw66zGMybCSK8i0gIwe_4c-hzHmn2woJkqYcqUyxbZUvj2liK1ZR9fb-G4YmE0OZpuDyTmYTQ6GZ4dvnZRZv8L4bfOP0ge9HoqS</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Vovenko, E. 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P. ; Chuikin, A. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2642-42eebd7388a29d69e5f49159037dfa31512a1f55b8ebdb3941d7da3e06317cf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anemia</topic><topic>Behavioral Sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood vessels</topic><topic>Electrodes</topic><topic>Hemoglobin</topic><topic>Hypoxia</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Physiology</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vovenko, E. P.</creatorcontrib><creatorcontrib>Chuikin, A. E.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Neuroscience and behavioral physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vovenko, E. P.</au><au>Chuikin, A. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Oxygen Tension Gradients in Small Cortical Microvessels in the Rat Brain on Development of Acute Anemia</atitle><jtitle>Neuroscience and behavioral physiology</jtitle><stitle>Neurosci Behav Physi</stitle><date>2013-07</date><risdate>2013</risdate><volume>43</volume><issue>6</issue><spage>748</spage><epage>754</epage><pages>748-754</pages><issn>0097-0549</issn><eissn>1573-899X</eissn><abstract>Oxygen microelectrodes were used to study longitudinal oxygen tension gradients (pO
2
) in small arterioles (with lumen diameters in control conditions of 5–20 μm) and capillaries in the rat cerebral cortex during stepwise decreases in the blood hemoglobin concentration ([Hb]) from an initial 14.4 ± 0.3 g/liter to 10.1 ± 0.2 (step 1), 7.0 ± 0.2 (step 2), and 3.7 ± 0.2 (step 3) g/liter. All data are presented as mean ± error of the mean. Oxygen tension was measured at two points in arteriole segments, separated from each other by distances of ΔL = 265 ± 34 μm,
n
= 30. The mean diameter of arteriole lumens in controls was 10.7 ± 0.5 μm,
n
= 71. The magnitude of the longitudinal pO
2
gradient (ΔpO
2
/ΔL) for the study arterioles was (mmHg/μm): 0.03 ± 0.01,
n
= 15 (controls), 0.06 ± 0.01,
n
= 16 (step 1), 0.07 ± 0.01,
n
= 14 (step 2), and 0.1 ± 0.01,
n
= 30 (step 3). In capillaries, ΔpO
2
/ΔL (with a segment length ΔL = 201 ± 45 μm,
n
= 18) was (mmHg/μm): 0.07 ± 0.01,
n
= 17 (controls), 0.09 ± 0.02,
n
= 16 (step 1), 0.08 ± 0.01,
n
= 15 (step 2), and 0.1 ± 0.02,
n
= 18 (step 3). The more than threefold decrease in oxygen content in arterial blood did not lead to significant changes (
p
> 0.05) in ΔpO
2
/ΔL in capillaries. Longitudinal hemoglobin oxygenation gradients (ΔSO
2
/ΔL) in capillaries (calculated using the animals' systemic blood oxyhemoglobin dissociation curve) was some three times greater than in arterioles, which provides evidence for the leading role of capillaries in supplying oxygen to the cerebral cortex in these conditions. These data include the first measurements of longitudinal pO
2
gradients in arterioles and capillaries in the cerebral cortex on development of acute anemia.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s11055-013-9804-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Anemia Behavioral Sciences Biomedical and Life Sciences Biomedicine Blood vessels Electrodes Hemoglobin Hypoxia Neurobiology Neurosciences Physiology Veins & arteries |
| title | Longitudinal Oxygen Tension Gradients in Small Cortical Microvessels in the Rat Brain on Development of Acute Anemia |
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