Distribution of genes of toxin-antitoxin systems of MazEF and RelBE families in bifidobacteria from human intestinal microbiota
The in silico analysis of 36 sequenced genomes of bacteria of the Bifidobacterium genus determined the presence of 19 genes of toxin-antitoxin (TA) system that belong to the MazEF and RelBE families, including five mazF and two relE genes that encode toxins and 12 relB genes that encode antitoxins....
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| Veröffentlicht in: | Russian journal of genetics 2013-03, Vol.49 (3), p.275-285 |
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| container_title | Russian journal of genetics |
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| creator | Averina, O. V. Alekseeva, M. G. Abilev, S. K. Ilyin, V. K. Danilenko, V. N. |
| description | The in silico analysis of 36 sequenced genomes of bacteria of the
Bifidobacterium
genus determined the presence of 19 genes of toxin-antitoxin (TA) system that belong to the MazEF and RelBE families, including five
mazF
and two
relE
genes that encode toxins and 12
relB
genes that encode antitoxins. A high level of gene (at the level of nucleotide changes) and genomic (presence or absence of genes in distinct genomes) polymorphism in the investigated genes was revealed. The highest level of polymorphism was observed in strains of the
Bifidobacterium longum
species, primarily in
relB1-relB10
genes. Gene and genomic polymorphism might be used to identify the strain of
B. longum
species. PCR analysis of genomic DNA of 30 bifidobacteria strains belonging to the three species,
B. longum, B. adolescentis
, and
B. bifidum
, isolated from the intestinal microbiota of astronauts demonstrated the presence of
mazF
and
relB
genes. The observed polymorphism of TA genes indicates the presence of differences in bifidobacteria strains isolated from the intestinal microbiota of astronauts before and after space flight and the control group. |
| doi_str_mv | 10.1134/S1022795413030022 |
| format | Article |
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Bifidobacterium
genus determined the presence of 19 genes of toxin-antitoxin (TA) system that belong to the MazEF and RelBE families, including five
mazF
and two
relE
genes that encode toxins and 12
relB
genes that encode antitoxins. A high level of gene (at the level of nucleotide changes) and genomic (presence or absence of genes in distinct genomes) polymorphism in the investigated genes was revealed. The highest level of polymorphism was observed in strains of the
Bifidobacterium longum
species, primarily in
relB1-relB10
genes. Gene and genomic polymorphism might be used to identify the strain of
B. longum
species. PCR analysis of genomic DNA of 30 bifidobacteria strains belonging to the three species,
B. longum, B. adolescentis
, and
B. bifidum
, isolated from the intestinal microbiota of astronauts demonstrated the presence of
mazF
and
relB
genes. The observed polymorphism of TA genes indicates the presence of differences in bifidobacteria strains isolated from the intestinal microbiota of astronauts before and after space flight and the control group.</description><identifier>ISSN: 1022-7954</identifier><identifier>EISSN: 1608-3369</identifier><identifier>DOI: 10.1134/S1022795413030022</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Animal Genetics and Genomics ; Antitoxins ; Bifidobacterium longum ; Biomedical and Life Sciences ; Biomedicine ; Genetics of Microorganisms ; Human Genetics ; Microbial Genetics and Genomics</subject><ispartof>Russian journal of genetics, 2013-03, Vol.49 (3), p.275-285</ispartof><rights>Pleiades Publishing, Ltd. 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-e59e9d2702c955fa3536a35388c7d332d4c25af4aa5f585cff6197309150791c3</citedby><cites>FETCH-LOGICAL-c321t-e59e9d2702c955fa3536a35388c7d332d4c25af4aa5f585cff6197309150791c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1022795413030022$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1022795413030022$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Averina, O. V.</creatorcontrib><creatorcontrib>Alekseeva, M. G.</creatorcontrib><creatorcontrib>Abilev, S. K.</creatorcontrib><creatorcontrib>Ilyin, V. K.</creatorcontrib><creatorcontrib>Danilenko, V. N.</creatorcontrib><title>Distribution of genes of toxin-antitoxin systems of MazEF and RelBE families in bifidobacteria from human intestinal microbiota</title><title>Russian journal of genetics</title><addtitle>Russ J Genet</addtitle><description>The in silico analysis of 36 sequenced genomes of bacteria of the
Bifidobacterium
genus determined the presence of 19 genes of toxin-antitoxin (TA) system that belong to the MazEF and RelBE families, including five
mazF
and two
relE
genes that encode toxins and 12
relB
genes that encode antitoxins. A high level of gene (at the level of nucleotide changes) and genomic (presence or absence of genes in distinct genomes) polymorphism in the investigated genes was revealed. The highest level of polymorphism was observed in strains of the
Bifidobacterium longum
species, primarily in
relB1-relB10
genes. Gene and genomic polymorphism might be used to identify the strain of
B. longum
species. PCR analysis of genomic DNA of 30 bifidobacteria strains belonging to the three species,
B. longum, B. adolescentis
, and
B. bifidum
, isolated from the intestinal microbiota of astronauts demonstrated the presence of
mazF
and
relB
genes. The observed polymorphism of TA genes indicates the presence of differences in bifidobacteria strains isolated from the intestinal microbiota of astronauts before and after space flight and the control group.</description><subject>Animal Genetics and Genomics</subject><subject>Antitoxins</subject><subject>Bifidobacterium longum</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Genetics of Microorganisms</subject><subject>Human Genetics</subject><subject>Microbial Genetics and Genomics</subject><issn>1022-7954</issn><issn>1608-3369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9UDtPwzAQthBIlMIPYPPIEvAjTuIRSgtIRUg85shx7OIqsYvtSJSFv47TsiGx3H2676G7A-Aco0uMaX71ghEhJWc5poiihA_ABBeoyigt-GHCaZSN_DE4CWGNEEaooBPwfWtC9KYZonEWOg1Xyqowgug-jc2EjWaHYNiGqPod9Si-5gsobAufVXczh1r0pjPJlmSN0aZ1jZBReSOg9q6H70MvbCKjCtFY0cHeSO8a46I4BUdadEGd_fYpeFvMX2f32fLp7mF2vcwkJThminHFW1IiIjljWlBGi7FUlSxbSkmbS8KEzoVgmlVMal1gXlLEMUMlx5JOwcU-d-Pdx5D2qHsTpOo6YZUbQo3zFI5YwUiS4r007RiCV7reeNMLv60xqsdn13-enTxk7wlJa1fK12s3-HRq-Mf0Az47gcg</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Averina, O. V.</creator><creator>Alekseeva, M. G.</creator><creator>Abilev, S. K.</creator><creator>Ilyin, V. K.</creator><creator>Danilenko, V. N.</creator><general>SP MAIK Nauka/Interperiodica</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130301</creationdate><title>Distribution of genes of toxin-antitoxin systems of MazEF and RelBE families in bifidobacteria from human intestinal microbiota</title><author>Averina, O. V. ; Alekseeva, M. G. ; Abilev, S. K. ; Ilyin, V. K. ; Danilenko, V. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-e59e9d2702c955fa3536a35388c7d332d4c25af4aa5f585cff6197309150791c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animal Genetics and Genomics</topic><topic>Antitoxins</topic><topic>Bifidobacterium longum</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Genetics of Microorganisms</topic><topic>Human Genetics</topic><topic>Microbial Genetics and Genomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Averina, O. V.</creatorcontrib><creatorcontrib>Alekseeva, M. G.</creatorcontrib><creatorcontrib>Abilev, S. K.</creatorcontrib><creatorcontrib>Ilyin, V. K.</creatorcontrib><creatorcontrib>Danilenko, V. N.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Russian journal of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Averina, O. V.</au><au>Alekseeva, M. G.</au><au>Abilev, S. K.</au><au>Ilyin, V. K.</au><au>Danilenko, V. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of genes of toxin-antitoxin systems of MazEF and RelBE families in bifidobacteria from human intestinal microbiota</atitle><jtitle>Russian journal of genetics</jtitle><stitle>Russ J Genet</stitle><date>2013-03-01</date><risdate>2013</risdate><volume>49</volume><issue>3</issue><spage>275</spage><epage>285</epage><pages>275-285</pages><issn>1022-7954</issn><eissn>1608-3369</eissn><abstract>The in silico analysis of 36 sequenced genomes of bacteria of the
Bifidobacterium
genus determined the presence of 19 genes of toxin-antitoxin (TA) system that belong to the MazEF and RelBE families, including five
mazF
and two
relE
genes that encode toxins and 12
relB
genes that encode antitoxins. A high level of gene (at the level of nucleotide changes) and genomic (presence or absence of genes in distinct genomes) polymorphism in the investigated genes was revealed. The highest level of polymorphism was observed in strains of the
Bifidobacterium longum
species, primarily in
relB1-relB10
genes. Gene and genomic polymorphism might be used to identify the strain of
B. longum
species. PCR analysis of genomic DNA of 30 bifidobacteria strains belonging to the three species,
B. longum, B. adolescentis
, and
B. bifidum
, isolated from the intestinal microbiota of astronauts demonstrated the presence of
mazF
and
relB
genes. The observed polymorphism of TA genes indicates the presence of differences in bifidobacteria strains isolated from the intestinal microbiota of astronauts before and after space flight and the control group.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S1022795413030022</doi><tpages>11</tpages></addata></record> |
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| ispartof | Russian journal of genetics, 2013-03, Vol.49 (3), p.275-285 |
| issn | 1022-7954 1608-3369 |
| language | eng |
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| subjects | Animal Genetics and Genomics Antitoxins Bifidobacterium longum Biomedical and Life Sciences Biomedicine Genetics of Microorganisms Human Genetics Microbial Genetics and Genomics |
| title | Distribution of genes of toxin-antitoxin systems of MazEF and RelBE families in bifidobacteria from human intestinal microbiota |
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