Regulation of adipolin/CTRP12 cleavage by obesity

► Obesity leads to an increase in the cleaved/full adipolin ratio in mouse plasma. ► The motif 90-KKSR-93 is necessary for cleavage of adipolin. ► Inhibitor for furin abolishes the level of cleaved adipolin in media from adipocytes. ► Furin is upregulated in TNF-treated adipocytes and fat tissues of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-11, Vol.428 (1), p.155-159
Hauptverfasser:	Enomoto, Takashi, Shibata, Rei, Ohashi, Koji, Kambara, Takahiro, Kataoka, Yoshiyuki, Uemura, Yusuke, Yuasa, Daisuke, Murohara, Toyoaki, Ouchi, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipokines - blood Adipokines - genetics Adipokines - metabolism Adipolin Adipose Tissue - enzymology Amino Acid Motifs Animals CTRP Diet - adverse effects Furin Furin - biosynthesis HEK293 Cells Humans Mice Mice, Inbred C57BL Obesity Obesity - blood Obesity - metabolism Proprotein convertase Proprotein Convertases - antagonists & inhibitors Proprotein Convertases - metabolism Sequence Deletion Thinness - blood Thinness - metabolism TNF Up-Regulation
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