Androgen receptor binding sites identified in mouse testis
Androgen/androgen receptor （AR） signaling plays decisive roles in testicular spermatogenesis [ 1 ]. However, the under- lying molecular mechanism of androgen and AR regulation （i.e. the genes that are regulated and their functions） remains largely undefined. Microarray analysis combined with an- dro...
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| Veröffentlicht in: | Acta biochimica et biophysica Sinica 2013-09, Vol.45 (9), p.795-797 |
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| container_title | Acta biochimica et biophysica Sinica |
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| creator | Hu, Shuanggang Yao, Guangxin Li, Xiangqi Chen, Zijiang Sun, Yun |
| description | Androgen/androgen receptor （AR） signaling plays decisive roles in testicular spermatogenesis [ 1 ]. However, the under- lying molecular mechanism of androgen and AR regulation （i.e. the genes that are regulated and their functions） remains largely undefined. Microarray analysis combined with an- drogen treatment or AR knockout animal models has iden- tified androgen-dependent genes in mouse testis [2,3]. However, this approach does not distinguish direct and indirect targets of androgen/AR. Until now, only a few AR-binding sites containing androgen responsive elements （AREs） located within the promoter regions of androgen re- sponsive genes in testis have these genes are direct targets been reported, |
| doi_str_mv | 10.1093/abbs/gmt076 |
| format | Article |
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However, the under- lying molecular mechanism of androgen and AR regulation （i.e. the genes that are regulated and their functions） remains largely undefined. Microarray analysis combined with an- drogen treatment or AR knockout animal models has iden- tified androgen-dependent genes in mouse testis [2,3]. However, this approach does not distinguish direct and indirect targets of androgen/AR. 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However, the under- lying molecular mechanism of androgen and AR regulation （i.e. the genes that are regulated and their functions） remains largely undefined. Microarray analysis combined with an- drogen treatment or AR knockout animal models has iden- tified androgen-dependent genes in mouse testis [2,3]. However, this approach does not distinguish direct and indirect targets of androgen/AR. Until now, only a few AR-binding sites containing androgen responsive elements （AREs） located within the promoter regions of androgen re- sponsive genes in testis have these genes are direct targets been reported,</description><subject>Androgens - metabolism</subject><subject>Androgens - pharmacology</subject><subject>Animals</subject><subject>Binding Sites - genetics</subject><subject>Chromatin Immunoprecipitation</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Homeodomain Proteins - genetics</subject><subject>Kallikreins - genetics</subject><subject>Male</subject><subject>Mice</subject><subject>Proteins - genetics</subject><subject>Receptors, Androgen - metabolism</subject><subject>Response Elements - genetics</subject><subject>Steroid 17-alpha-Hydroxylase - genetics</subject><subject>Testis - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>分子机制</subject><subject>受体结合位点</subject><subject>基因敲除</subject><subject>小鼠睾丸</subject><subject>微阵列分析</subject><subject>激素反应元件</subject><subject>生精功能</subject><subject>雄激素受体</subject><issn>1672-9145</issn><issn>1745-7270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhiMEYmNw4o7KDQmVxUmbNNymiS9pEhc4V2nilqA13ZLuwL8n0wYnW9aj1_ZDyDXQB6CKz3XTxHnXj1SKEzIFWZS5ZJKepl5Ilisoygm5iPGbUi4E0HMyYbziVSnVlDwuvA1Dhz4LaHAzDiFrnLfOd1l0I8bMWfSjax3azPmsH3YRszQfXbwkZ61eR7w61hn5fH76WL7mq_eXt-VilRsm-ZgbSg0WIJnhqK0Fxjm2TOmiRYmlRUBsmAIoKW1QmFIY1UKjK2Wx1cZqPiN3h9xNGLa7tLruXTS4XmuP6ZwaivQtBS4hofcH1IQhxoBtvQmu1-GnBlrvZdV7WfVBVqJvjsG7pkf7z_7ZScDtMe5r8N02SflnCkkrIQrFfwHQKXLQ</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Hu, Shuanggang</creator><creator>Yao, Guangxin</creator><creator>Li, Xiangqi</creator><creator>Chen, Zijiang</creator><creator>Sun, Yun</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Androgen receptor binding sites identified in mouse testis</title><author>Hu, Shuanggang ; Yao, Guangxin ; Li, Xiangqi ; Chen, Zijiang ; Sun, Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-c00ce4172c3eadd1233ef29a4fe7e5de1eeb2911500be6c56c9f1ba89defacda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Androgens - metabolism</topic><topic>Androgens - pharmacology</topic><topic>Animals</topic><topic>Binding Sites - genetics</topic><topic>Chromatin Immunoprecipitation</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Homeodomain Proteins - genetics</topic><topic>Kallikreins - genetics</topic><topic>Male</topic><topic>Mice</topic><topic>Proteins - genetics</topic><topic>Receptors, Androgen - metabolism</topic><topic>Response Elements - genetics</topic><topic>Steroid 17-alpha-Hydroxylase - genetics</topic><topic>Testis - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>分子机制</topic><topic>受体结合位点</topic><topic>基因敲除</topic><topic>小鼠睾丸</topic><topic>微阵列分析</topic><topic>激素反应元件</topic><topic>生精功能</topic><topic>雄激素受体</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Shuanggang</creatorcontrib><creatorcontrib>Yao, Guangxin</creatorcontrib><creatorcontrib>Li, Xiangqi</creatorcontrib><creatorcontrib>Chen, Zijiang</creatorcontrib><creatorcontrib>Sun, Yun</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biochimica et biophysica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Shuanggang</au><au>Yao, Guangxin</au><au>Li, Xiangqi</au><au>Chen, Zijiang</au><au>Sun, Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Androgen receptor binding sites identified in mouse testis</atitle><jtitle>Acta biochimica et biophysica Sinica</jtitle><addtitle>Acta Biochimica et Biophysica Sinica</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>45</volume><issue>9</issue><spage>795</spage><epage>797</epage><pages>795-797</pages><issn>1672-9145</issn><eissn>1745-7270</eissn><abstract>Androgen/androgen receptor （AR） signaling plays decisive roles in testicular spermatogenesis [ 1 ]. However, the under- lying molecular mechanism of androgen and AR regulation （i.e. the genes that are regulated and their functions） remains largely undefined. Microarray analysis combined with an- drogen treatment or AR knockout animal models has iden- tified androgen-dependent genes in mouse testis [2,3]. However, this approach does not distinguish direct and indirect targets of androgen/AR. Until now, only a few AR-binding sites containing androgen responsive elements （AREs） located within the promoter regions of androgen re- sponsive genes in testis have these genes are direct targets been reported,</abstract><cop>China</cop><pmid>23838579</pmid><doi>10.1093/abbs/gmt076</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1672-9145 |
| ispartof | Acta biochimica et biophysica Sinica, 2013-09, Vol.45 (9), p.795-797 |
| issn | 1672-9145 1745-7270 |
| language | eng |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; PubMed Central; Alma/SFX Local Collection |
| subjects | Androgens - metabolism Androgens - pharmacology Animals Binding Sites - genetics Chromatin Immunoprecipitation Gene Expression Regulation - drug effects Homeodomain Proteins - genetics Kallikreins - genetics Male Mice Proteins - genetics Receptors, Androgen - metabolism Response Elements - genetics Steroid 17-alpha-Hydroxylase - genetics Testis - metabolism Transcription Factors - genetics 分子机制 受体结合位点 基因敲除 小鼠睾丸 微阵列分析 激素反应元件 生精功能 雄激素受体 |
| title | Androgen receptor binding sites identified in mouse testis |
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