Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres

ABSTRACT Current strategies for bone regeneration after traumatic injury often fail to provide adequate healing and integration. Here, we combined the poly (ethylene glycol) diacrylate (PEGDA) hydrogel with allogeneic “carrier” cells transduced with an adenovirus expressing BMP2. The system is uniqu...

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Veröffentlicht in:	Journal of orthopaedic research 2013-10, Vol.31 (10), p.1597-1604
Hauptverfasser:	Sonnet, Corinne, Simpson, C. LaShan, Olabisi, Ronke M., Sullivan, Kayleigh, Lazard, ZaWaunyka, Gugala, Zbigniew, Peroni, John F., Weh, J. Michael, Davis, Alan R., West, Jennifer L., Olmsted-Davis, Elizabeth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomechanical Phenomena - drug effects Biomechanical Phenomena - physiology BMP2 bone healing Bone Morphogenetic Protein 2 - pharmacology critical size defect Disease Models, Animal Dose-Response Relationship, Drug Drug Compounding - methods Femoral Fractures - diagnostic imaging Femoral Fractures - drug therapy Femoral Fractures - physiopathology Femur - drug effects Femur - physiology Fibroblasts - cytology Fracture Healing - drug effects Fracture Healing - physiology Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology microencapsulation Microspheres PEGDA Polyethylene Glycols - pharmacology Radiography Rats Rats, Wistar Skin - cytology Stromal Cells - cytology
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