Metabolite extract of Streptomyces hygroscopicus Hygroscopicus inhibit the growth of Plasmodium berghei through inhibition of ubiquitin - proteasome system

Streptomyces hygroscopicus Hygroscopicus, a member of family of Actinomycetes produces eponemycin a proteasome inhibitor that can inhibit Ubiquitin-Proteasome System (UPS) function in eukaryotic cell. Previous study showed that coronamycin, an active substrate isolated from Streptomyces sp. can act...

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Veröffentlicht in:	Tropical biomedicine 2013-06, Vol.30 (2), p.291-300
Hauptverfasser:	Rivo, Y B, Alkarimah, A, Ramadhani, N N, Cahyono, A W, Laksmi, D A, Winarsih, S, Fitri, L E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - isolation & purification Antimalarials - therapeutic use Blotting, Western Disease Models, Animal Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - therapeutic use Enzyme-Linked Immunosorbent Assay Malaria - drug therapy Malaria - parasitology Male Mice Mice, Inbred BALB C Parasitemia - drug therapy Parasitemia - parasitology Plasmodium Plasmodium berghei - cytology Plasmodium berghei - drug effects Polyubiquitin - analysis Proteasome Endopeptidase Complex - drug effects Streptomyces - metabolism Treatment Outcome Ubiquitin - antagonists & inhibitors
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