Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction

A small-molecule activator of Wnt/β-catenin signaling acts by binding a negative regulator of β-catenin, Axin, leading to a conformational change that promotes association of Axin with LRP6. The Wnt/β-catenin signaling pathway has a crucial role in embryonic development, stem cell maintenance and hu...

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Veröffentlicht in:	Nature chemical biology 2013-09, Vol.9 (9), p.579-585
Hauptverfasser:	Wang, Sheng, Yin, Junlin, Chen, Duozhi, Nie, Fen, Song, Xiaomin, Fei, Cong, Miao, Haofei, Jing, Changbin, Ma, Wenjing, Wang, Lei, Xie, Sichun, Li, Chen, Zeng, Rong, Pan, Weijun, Hao, Xiaojiang, Li, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/86 631/92/555 631/92/613 Animals Axin Protein - antagonists & inhibitors Axin Protein - chemistry Axin Protein - metabolism Benzodioxoles - chemistry Benzodioxoles - pharmacology Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemistry Chemistry/Food Science Embryonic growth stage Embryos HEK293 Cells Humans Low Density Lipoprotein Receptor-Related Protein-5 - chemistry Low Density Lipoprotein Receptor-Related Protein-5 - metabolism Low Density Lipoprotein Receptor-Related Protein-6 - chemistry Low Density Lipoprotein Receptor-Related Protein-6 - metabolism Molecules Phenanthridines - chemistry Phenanthridines - pharmacology Phosphorylation Protein Binding - drug effects Signal transduction Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Stem cells Wnt Proteins - metabolism Wnt Signaling Pathway - drug effects Zebrafish - embryology Zebrafish - metabolism
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