Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract
On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), this paper reports the first congener-specific analysis of a commercial PCB preparation, Aroclor 1260, and the PCB composition of a human milk extract. The analysis indicates that...
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| Veröffentlicht in: | J. Agric. Food Chem.; (United States) 1985-01, Vol.33 (1), p.24-29 |
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| creator | Safe, Stephen Safe, Lorna Mullin, Michael |
| description | On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), this paper reports the first congener-specific analysis of a commercial PCB preparation, Aroclor 1260, and the PCB composition of a human milk extract. The analysis indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2,2',3,4',5',6-, 2,2,3,4,4',5,5'-, 2,2'3,4,5,5'-, and 2,2'3,4,4',5'-hexachlorobipheny l and 2,2'3,3',4,4',5-, 2,2',3,3',4,5,6'-, 2,2',3,4,4',5,5'-, and 2,2',3,4',5,5',6-heptachlorobiphenyl. In contrast, the major PCB components of the human milk fraction were the 2,4,4'-tri-, 2,4,4',5-tetra-, 2,2',4,4'5-penta-, 2,3',4,4',5-penta-, 2,2',3,4,4',5'-hexa-, 2,2',4,4',5,5'-hexa-, 2,2'3,3',4,4',5-hepta-, and 2,2'3,4,4',5,5'-heptachlorobiphenyls. The significance of congener-specific PCB analysis is dicussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity. |
| doi_str_mv | 10.1021/jf00061a007 |
| format | Article |
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The analysis indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2,2',3,4',5',6-, 2,2,3,4,4',5,5'-, 2,2'3,4,5,5'-, and 2,2'3,4,4',5'-hexachlorobipheny l and 2,2'3,3',4,4',5-, 2,2',3,3',4,5,6'-, 2,2',3,4,4',5,5'-, and 2,2',3,4',5,5',6-heptachlorobiphenyl. In contrast, the major PCB components of the human milk fraction were the 2,4,4'-tri-, 2,4,4',5-tetra-, 2,2',4,4'5-penta-, 2,3',4,4',5-penta-, 2,2',3,4,4',5'-hexa-, 2,2',4,4',5,5'-hexa-, 2,2'3,3',4,4',5-hepta-, and 2,2'3,4,4',5,5'-heptachlorobiphenyls. The significance of congener-specific PCB analysis is dicussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf00061a007</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ANIMALS ; Applied sciences ; AROMATICS ; BIOLOGICAL ACCUMULATION ; BIOLOGICAL MATERIALS ; BODY FLUIDS ; CHEMICAL ANALYSIS ; CHLORINATED AROMATIC HYDROCARBONS ; Exact sciences and technology ; FOOD ; HALOGENATED AROMATIC HYDROCARBONS ; MAMMALS ; MAN ; MATERIALS ; MILK ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; Other techniques and industries ; PRIMATES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Food Chem.; (United States), 1985-01, Vol.33 (1), p.24-29</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a454t-9ca44824777bd14affeeb7354c90639460896e5907b5ff0abf9ebccbe63bc1a43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf00061a007$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf00061a007$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,886,2766,4025,27080,27927,27928,27929,56742,56792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8835771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/7009641$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Safe, Stephen</creatorcontrib><creatorcontrib>Safe, Lorna</creatorcontrib><creatorcontrib>Mullin, Michael</creatorcontrib><creatorcontrib>Texas A and M Univ., College Station</creatorcontrib><title>Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract</title><title>J. Agric. Food Chem.; (United States)</title><addtitle>J. Agric. Food Chem</addtitle><description>On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), this paper reports the first congener-specific analysis of a commercial PCB preparation, Aroclor 1260, and the PCB composition of a human milk extract. The analysis indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2,2',3,4',5',6-, 2,2,3,4,4',5,5'-, 2,2'3,4,5,5'-, and 2,2'3,4,4',5'-hexachlorobipheny l and 2,2'3,3',4,4',5-, 2,2',3,3',4,5,6'-, 2,2',3,4,4',5,5'-, and 2,2',3,4',5,5',6-heptachlorobiphenyl. In contrast, the major PCB components of the human milk fraction were the 2,4,4'-tri-, 2,4,4',5-tetra-, 2,2',4,4'5-penta-, 2,3',4,4',5-penta-, 2,2',3,4,4',5'-hexa-, 2,2',4,4',5,5'-hexa-, 2,2'3,3',4,4',5-hepta-, and 2,2'3,4,4',5,5'-heptachlorobiphenyls. The significance of congener-specific PCB analysis is dicussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ANIMALS</subject><subject>Applied sciences</subject><subject>AROMATICS</subject><subject>BIOLOGICAL ACCUMULATION</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BODY FLUIDS</subject><subject>CHEMICAL ANALYSIS</subject><subject>CHLORINATED AROMATIC HYDROCARBONS</subject><subject>Exact sciences and technology</subject><subject>FOOD</subject><subject>HALOGENATED AROMATIC HYDROCARBONS</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MATERIALS</subject><subject>MILK</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>Other techniques and industries</subject><subject>PRIMATES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>STRUCTURE-ACTIVITY RELATIONSHIPS</subject><subject>TOXICITY</subject><subject>VERTEBRATES</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNpt0cFu1DAQBuAIgcRSOPECEUJwqAL2xo4TbqgUFqkSRV04cLEms2PWWydZPI60-_a42qriwMmS_8_j8bgoXkrxToqlfL9zQohGghDmUbGQeikqLWX7uFiIHFetbuTT4hnzLrNWG7Eo3PUUjrgNU_QjJNqUvd9vaTwG_lDiNP6mkWLFe0LvPJYwQjiy53JyJeR8GCiih1AO_pDmSBlscrCdBxjzXrgt6ZAiYHpePHEQmF7cr2fFj8-X64tVdfXty9eLj1cVKK1S1SEo1S6VMabfSAXOEfWm1go70dSdakTbNaQ7YXrtnIDeddQj9tTUPUpQ9Vnx6lR34uQto0-E2_yOkTBZI0TXKJnRmxPax-nPTJzs4BkpBBhpmtlKtWy0Em2G5yeIcWKO5Ow--gHi0Uph7wZu_xl41q_vywIjBBdhRM8PR9q21sbc3V6dmOdEh4cY4q1tTG20XV_f2Jvvq_WvTz9bu8r-7ckDst1Nc8x_wP9t4C8gF5zD</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Safe, Stephen</creator><creator>Safe, Lorna</creator><creator>Mullin, Michael</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>19850101</creationdate><title>Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract</title><author>Safe, Stephen ; Safe, Lorna ; Mullin, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a454t-9ca44824777bd14affeeb7354c90639460896e5907b5ff0abf9ebccbe63bc1a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ANIMALS</topic><topic>Applied sciences</topic><topic>AROMATICS</topic><topic>BIOLOGICAL ACCUMULATION</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BODY FLUIDS</topic><topic>CHEMICAL ANALYSIS</topic><topic>CHLORINATED AROMATIC HYDROCARBONS</topic><topic>Exact sciences and technology</topic><topic>FOOD</topic><topic>HALOGENATED AROMATIC HYDROCARBONS</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MATERIALS</topic><topic>MILK</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>Other techniques and industries</topic><topic>PRIMATES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>STRUCTURE-ACTIVITY RELATIONSHIPS</topic><topic>TOXICITY</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Safe, Stephen</creatorcontrib><creatorcontrib>Safe, Lorna</creatorcontrib><creatorcontrib>Mullin, Michael</creatorcontrib><creatorcontrib>Texas A and M Univ., College Station</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>J. Agric. Food Chem.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Safe, Stephen</au><au>Safe, Lorna</au><au>Mullin, Michael</au><aucorp>Texas A and M Univ., College Station</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract</atitle><jtitle>J. Agric. Food Chem.; (United States)</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>33</volume><issue>1</issue><spage>24</spage><epage>29</epage><pages>24-29</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), this paper reports the first congener-specific analysis of a commercial PCB preparation, Aroclor 1260, and the PCB composition of a human milk extract. The analysis indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2,2',3,4',5',6-, 2,2,3,4,4',5,5'-, 2,2'3,4,5,5'-, and 2,2'3,4,4',5'-hexachlorobipheny l and 2,2'3,3',4,4',5-, 2,2',3,3',4,5,6'-, 2,2',3,4,4',5,5'-, and 2,2',3,4',5,5',6-heptachlorobiphenyl. In contrast, the major PCB components of the human milk fraction were the 2,4,4'-tri-, 2,4,4',5-tetra-, 2,2',4,4'5-penta-, 2,3',4,4',5-penta-, 2,2',3,4,4',5'-hexa-, 2,2',4,4',5,5'-hexa-, 2,2'3,3',4,4',5-hepta-, and 2,2'3,4,4',5,5'-heptachlorobiphenyls. The significance of congener-specific PCB analysis is dicussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/jf00061a007</doi><tpages>6</tpages></addata></record> |
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| ispartof | J. Agric. Food Chem.; (United States), 1985-01, Vol.33 (1), p.24-29 |
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| language | eng |
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| source | ACS Publications |
| subjects | 560300 - Chemicals Metabolism & Toxicology ANIMALS Applied sciences AROMATICS BIOLOGICAL ACCUMULATION BIOLOGICAL MATERIALS BODY FLUIDS CHEMICAL ANALYSIS CHLORINATED AROMATIC HYDROCARBONS Exact sciences and technology FOOD HALOGENATED AROMATIC HYDROCARBONS MAMMALS MAN MATERIALS MILK ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS Other techniques and industries PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT STRUCTURE-ACTIVITY RELATIONSHIPS TOXICITY VERTEBRATES |
| title | Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract |
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