Effect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liver
Abstract Background The aim of this study was to investigate the effects of prostaglandin E-1 (PGE-1) on preservation injury in livers perfused with the University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solutions. Materials and methods Five groups each including six rats inclu...
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| Veröffentlicht in: | Transplantation proceedings 2013-07, Vol.45 (6), p.2446-2450 |
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| creator | Aliosmanoglu, I Sevmis, S Karakayali, H Kocbiyik, A Dagdeviren, A Haberal, A Haberal, M |
| description | Abstract Background The aim of this study was to investigate the effects of prostaglandin E-1 (PGE-1) on preservation injury in livers perfused with the University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solutions. Materials and methods Five groups each including six rats included. Ringer’s lactate RL (group 1), HTK (group 2), HTK + PGE-1 (group 3), UW (group 4), or UW PGE-1 (group 5). Liver tissue and preservation fluid samples were obtained from the perfused lives for pathological and biochemical examinations respectively at 0, 6 and 12 hours. Results Upon biochemical examination, aspartate aminotrasnferase and alanine aminotransferase values were highest among the group with RL solution and lowest with PGE-1. Liver structure was found to be damaged immediately after RL solution, whereas it was preserved in the other four groups. Fewer cellular changes were reported at the end of 12 hours in the groups administered PGE-1 compared with the other groups. Conclusions PGE-1 when applied before preservation protected liver functions, decreased pathologic injury, and delayed changes that occur under cold ischemic conditions. |
| doi_str_mv | 10.1016/j.transproceed.2012.05.093 |
| format | Article |
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Materials and methods Five groups each including six rats included. Ringer’s lactate RL (group 1), HTK (group 2), HTK + PGE-1 (group 3), UW (group 4), or UW PGE-1 (group 5). Liver tissue and preservation fluid samples were obtained from the perfused lives for pathological and biochemical examinations respectively at 0, 6 and 12 hours. Results Upon biochemical examination, aspartate aminotrasnferase and alanine aminotransferase values were highest among the group with RL solution and lowest with PGE-1. Liver structure was found to be damaged immediately after RL solution, whereas it was preserved in the other four groups. Fewer cellular changes were reported at the end of 12 hours in the groups administered PGE-1 compared with the other groups. Conclusions PGE-1 when applied before preservation protected liver functions, decreased pathologic injury, and delayed changes that occur under cold ischemic conditions.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2012.05.093</identifier><identifier>PMID: 23871184</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenosine - pharmacology ; Alanine Transaminase - metabolism ; Allopurinol - pharmacology ; Alprostadil - pharmacology ; Animals ; Aspartate Aminotransferases - metabolism ; Biomarkers - metabolism ; Cold Ischemia - adverse effects ; Cytoprotection ; Glucose - pharmacology ; Glutathione - pharmacology ; Hepatectomy ; Insulin - pharmacology ; Isotonic Solutions - pharmacology ; Liver - blood supply ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Male ; Mannitol - pharmacology ; Organ Preservation - methods ; Organ Preservation Solutions - pharmacology ; Perfusion ; Potassium Chloride - pharmacology ; Procaine - pharmacology ; Raffinose - pharmacology ; Rats ; Rats, Wistar ; Reperfusion Injury - etiology ; Reperfusion Injury - metabolism ; Reperfusion Injury - pathology ; Reperfusion Injury - prevention & control ; Surgery ; Time Factors</subject><ispartof>Transplantation proceedings, 2013-07, Vol.45 (6), p.2446-2450</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-649619c66ae801247bb64da91d537ca219c0f9d9f1bd0770567d2ce94cf734703</citedby><cites>FETCH-LOGICAL-c435t-649619c66ae801247bb64da91d537ca219c0f9d9f1bd0770567d2ce94cf734703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134512012973$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23871184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aliosmanoglu, I</creatorcontrib><creatorcontrib>Sevmis, S</creatorcontrib><creatorcontrib>Karakayali, H</creatorcontrib><creatorcontrib>Kocbiyik, A</creatorcontrib><creatorcontrib>Dagdeviren, A</creatorcontrib><creatorcontrib>Haberal, A</creatorcontrib><creatorcontrib>Haberal, M</creatorcontrib><title>Effect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liver</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Background The aim of this study was to investigate the effects of prostaglandin E-1 (PGE-1) on preservation injury in livers perfused with the University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solutions. Materials and methods Five groups each including six rats included. Ringer’s lactate RL (group 1), HTK (group 2), HTK + PGE-1 (group 3), UW (group 4), or UW PGE-1 (group 5). Liver tissue and preservation fluid samples were obtained from the perfused lives for pathological and biochemical examinations respectively at 0, 6 and 12 hours. Results Upon biochemical examination, aspartate aminotrasnferase and alanine aminotransferase values were highest among the group with RL solution and lowest with PGE-1. Liver structure was found to be damaged immediately after RL solution, whereas it was preserved in the other four groups. Fewer cellular changes were reported at the end of 12 hours in the groups administered PGE-1 compared with the other groups. Conclusions PGE-1 when applied before preservation protected liver functions, decreased pathologic injury, and delayed changes that occur under cold ischemic conditions.</description><subject>Adenosine - pharmacology</subject><subject>Alanine Transaminase - metabolism</subject><subject>Allopurinol - pharmacology</subject><subject>Alprostadil - pharmacology</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Cold Ischemia - adverse effects</subject><subject>Cytoprotection</subject><subject>Glucose - pharmacology</subject><subject>Glutathione - pharmacology</subject><subject>Hepatectomy</subject><subject>Insulin - pharmacology</subject><subject>Isotonic Solutions - pharmacology</subject><subject>Liver - blood supply</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Mannitol - pharmacology</subject><subject>Organ Preservation - methods</subject><subject>Organ Preservation Solutions - pharmacology</subject><subject>Perfusion</subject><subject>Potassium Chloride - pharmacology</subject><subject>Procaine - pharmacology</subject><subject>Raffinose - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion Injury - etiology</subject><subject>Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Surgery</subject><subject>Time Factors</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1DAQtRCILoVfQBEnLgl27MQbDkioLLRiJZDaiqPltSetl6y9tZ2V8jXwLXwZE20rASdOtmfevPG8N4S8YrRilLVvtlWO2qd9DAbAVjVldUWbinb8EVmwpeRl3db8MVlQKljJuGhOyLOUthTfteBPyUnNl5KxpViQH6u-B5OL0BdfY0hZ3wzaW-eLVcmK4ItvLpngEwauvTtATC5PBSKKc5eyQyCUV3Ha57C_1b78DDncDGPWUWdAQkgQDzo7JLoMGMdLQtZfP_9KXfjtGKf5C_kWqyD2YwJbrOd-z8mTXg8JXtyfp-T64-rq7Lxcf_l0cfZ-XRrBm1y2omtZZ9pWwxLlEHKzaYXVHbMNl0bXmKN9Z7uebSyVkjattLWBTpheciEpPyWvj7yo6t0IKasdTg4DqgFhTIqJum2Y5LRF6Nsj1KBgKUKv9tHtdJwUo2o2SG3Vnwap2SBFG4UGYfHL-z7jZoe5h9IHRxDw4QgAnPbgIKpkHHgD1kU0Stng_q_Pu39ozOC8M3r4DhOkbRijRz0VUwlr1OW8KvOmsJmkk5z_BnDuwek</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Aliosmanoglu, I</creator><creator>Sevmis, S</creator><creator>Karakayali, H</creator><creator>Kocbiyik, A</creator><creator>Dagdeviren, A</creator><creator>Haberal, A</creator><creator>Haberal, M</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Effect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liver</title><author>Aliosmanoglu, I ; Sevmis, S ; Karakayali, H ; Kocbiyik, A ; Dagdeviren, A ; Haberal, A ; Haberal, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-649619c66ae801247bb64da91d537ca219c0f9d9f1bd0770567d2ce94cf734703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenosine - pharmacology</topic><topic>Alanine Transaminase - metabolism</topic><topic>Allopurinol - pharmacology</topic><topic>Alprostadil - pharmacology</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Cold Ischemia - adverse effects</topic><topic>Cytoprotection</topic><topic>Glucose - pharmacology</topic><topic>Glutathione - pharmacology</topic><topic>Hepatectomy</topic><topic>Insulin - pharmacology</topic><topic>Isotonic Solutions - pharmacology</topic><topic>Liver - blood supply</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Mannitol - pharmacology</topic><topic>Organ Preservation - methods</topic><topic>Organ Preservation Solutions - pharmacology</topic><topic>Perfusion</topic><topic>Potassium Chloride - pharmacology</topic><topic>Procaine - pharmacology</topic><topic>Raffinose - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion Injury - etiology</topic><topic>Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Surgery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aliosmanoglu, I</creatorcontrib><creatorcontrib>Sevmis, S</creatorcontrib><creatorcontrib>Karakayali, H</creatorcontrib><creatorcontrib>Kocbiyik, A</creatorcontrib><creatorcontrib>Dagdeviren, A</creatorcontrib><creatorcontrib>Haberal, A</creatorcontrib><creatorcontrib>Haberal, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aliosmanoglu, I</au><au>Sevmis, S</au><au>Karakayali, H</au><au>Kocbiyik, A</au><au>Dagdeviren, A</au><au>Haberal, A</au><au>Haberal, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liver</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>45</volume><issue>6</issue><spage>2446</spage><epage>2450</epage><pages>2446-2450</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>Abstract Background The aim of this study was to investigate the effects of prostaglandin E-1 (PGE-1) on preservation injury in livers perfused with the University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solutions. Materials and methods Five groups each including six rats included. Ringer’s lactate RL (group 1), HTK (group 2), HTK + PGE-1 (group 3), UW (group 4), or UW PGE-1 (group 5). Liver tissue and preservation fluid samples were obtained from the perfused lives for pathological and biochemical examinations respectively at 0, 6 and 12 hours. Results Upon biochemical examination, aspartate aminotrasnferase and alanine aminotransferase values were highest among the group with RL solution and lowest with PGE-1. Liver structure was found to be damaged immediately after RL solution, whereas it was preserved in the other four groups. Fewer cellular changes were reported at the end of 12 hours in the groups administered PGE-1 compared with the other groups. Conclusions PGE-1 when applied before preservation protected liver functions, decreased pathologic injury, and delayed changes that occur under cold ischemic conditions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23871184</pmid><doi>10.1016/j.transproceed.2012.05.093</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine - pharmacology Alanine Transaminase - metabolism Allopurinol - pharmacology Alprostadil - pharmacology Animals Aspartate Aminotransferases - metabolism Biomarkers - metabolism Cold Ischemia - adverse effects Cytoprotection Glucose - pharmacology Glutathione - pharmacology Hepatectomy Insulin - pharmacology Isotonic Solutions - pharmacology Liver - blood supply Liver - drug effects Liver - enzymology Liver - pathology Male Mannitol - pharmacology Organ Preservation - methods Organ Preservation Solutions - pharmacology Perfusion Potassium Chloride - pharmacology Procaine - pharmacology Raffinose - pharmacology Rats Rats, Wistar Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control Surgery Time Factors |
| title | Effect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liver |
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