Effect of Hypogammaglobulinemia on the Incidence of Community-Acquired Respiratory Viral Infections After Lung Transplantation
Abstract Background Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipi...
Gespeichert in:
| Veröffentlicht in: | Transplantation proceedings 2013-07, Vol.45 (6), p.2371-2374 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2374 |
|---|---|
| container_issue | 6 |
| container_start_page | 2371 |
| container_title | Transplantation proceedings |
| container_volume | 45 |
| creator | Noell, B.C Dawson, K.L Seethamraju, H |
| description | Abstract Background Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipients with HGG are at an increased risk of developing CARV infection. Secondary endpoints included the effect of HGG on lung function, incidence of rejection, and mortality. Methods A retrospective review of all lung transplant recipients from 2008 to 2011 was performed. Patients were stratified as either having HGG after transplantation or having normal IgG titers according to their nadir IgG level. HGG was defined a serum IgG level of |
| doi_str_mv | 10.1016/j.transproceed.2012.11.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1426516467</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0041134512013164</els_id><sourcerecordid>1426516467</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-f7ba8e095bd1d4e5be450bfd1519b4107fe1c8137f69253493369bb81774e6ab3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEokvhLyCLE5cET-x8cUBaLYVWWgkJClfLccaLl8Te2g5SLvx2HLaVECdOtjXvvDPzeLLsFdACKNRvjkX00oaTdwpxKEoKZQFQUKCPsg20DcvLumSPsw2lHHJgvLrInoVwpOldcvY0uyhZwxto603260prVJE4Ta6XkzvIaZKH0fXzaCxORhJnSfyO5MYqM6BVuCp3bppma-KSb9XdbDwO5DOGk_EyOr-Qb-kypozV2DgbyFZH9GQ_2wO5_dP5KG2Ua-x59kTLMeCL-_My-_rh6nZ3ne8_fbzZbfe54qyKuW562SLtqn6AgWPVI69orweooOs50EYjqBZYo-uurBjvGKu7vm-haTjWsmeX2euzb4J2N2OIYjJB4ZgaQTcHAbysK6h53STp27NUeReCRy1O3kzSLwKoWPmLo_ibv1j5CwCR-Kfkl_d15n5KsYfUB-BJ8P4swDTtT4NeBGVWrkPCqKIYnPm_Ou_-sVHpw4yS4w9cMBzd7G3iKUCEUlDxZd2EdREgmbA0J_sNzkS0zQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1426516467</pqid></control><display><type>article</type><title>Effect of Hypogammaglobulinemia on the Incidence of Community-Acquired Respiratory Viral Infections After Lung Transplantation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Noell, B.C ; Dawson, K.L ; Seethamraju, H</creator><creatorcontrib>Noell, B.C ; Dawson, K.L ; Seethamraju, H</creatorcontrib><description>Abstract Background Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipients with HGG are at an increased risk of developing CARV infection. Secondary endpoints included the effect of HGG on lung function, incidence of rejection, and mortality. Methods A retrospective review of all lung transplant recipients from 2008 to 2011 was performed. Patients were stratified as either having HGG after transplantation or having normal IgG titers according to their nadir IgG level. HGG was defined a serum IgG level of <700 mg/dL. CARVs included human metapneumovirus, influenza A/B, respiratory syncytial virus A/B, parainfluenza 1/2/3, rhinovirus, and adenovirus isolated from bronchoalveolar lavage/wash, sputum, or nasal swab. Results The cohort consisted of 263 patients with a mean follow-up time of 612 ± 356 days. The incidence of CARV infection was 27% in patients with normal IgG titers and 23.4% in patients with HGG ( P = .62). No difference in rejection, mortality, or lung function was found between the groups. As expected, patients who ever had a CARV infection had a significantly lower 1-second forced expiratory volume % reference on their most recent spirometry than those who had not had a CARV infection (81.6% vs 86.9%; P = .027). Conclusions Although CARV infection has been shown to affect lung graft function, these data suggests that HGG is not associated with the incidence of CARV infection.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2012.11.010</identifier><identifier>PMID: 23747186</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Biomarkers - blood ; Common Variable Immunodeficiency - diagnosis ; Common Variable Immunodeficiency - epidemiology ; Common Variable Immunodeficiency - mortality ; Community-Acquired Infections - diagnosis ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - mortality ; Community-Acquired Infections - virology ; Female ; Forced Expiratory Volume ; Graft Rejection - epidemiology ; Humans ; Immunoglobulin G - blood ; Incidence ; Kaplan-Meier Estimate ; Lung - physiopathology ; Lung - virology ; Lung Transplantation - adverse effects ; Lung Transplantation - mortality ; Male ; Middle Aged ; Respiratory Function Tests ; Respiratory Tract Infections - diagnosis ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - mortality ; Respiratory Tract Infections - virology ; Retrospective Studies ; Risk Factors ; Surgery ; Texas - epidemiology ; Time Factors ; Treatment Outcome ; Virus Diseases - diagnosis ; Virus Diseases - epidemiology ; Virus Diseases - mortality ; Virus Diseases - virology</subject><ispartof>Transplantation proceedings, 2013-07, Vol.45 (6), p.2371-2374</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-f7ba8e095bd1d4e5be450bfd1519b4107fe1c8137f69253493369bb81774e6ab3</citedby><cites>FETCH-LOGICAL-c435t-f7ba8e095bd1d4e5be450bfd1519b4107fe1c8137f69253493369bb81774e6ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2012.11.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23747186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noell, B.C</creatorcontrib><creatorcontrib>Dawson, K.L</creatorcontrib><creatorcontrib>Seethamraju, H</creatorcontrib><title>Effect of Hypogammaglobulinemia on the Incidence of Community-Acquired Respiratory Viral Infections After Lung Transplantation</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Background Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipients with HGG are at an increased risk of developing CARV infection. Secondary endpoints included the effect of HGG on lung function, incidence of rejection, and mortality. Methods A retrospective review of all lung transplant recipients from 2008 to 2011 was performed. Patients were stratified as either having HGG after transplantation or having normal IgG titers according to their nadir IgG level. HGG was defined a serum IgG level of <700 mg/dL. CARVs included human metapneumovirus, influenza A/B, respiratory syncytial virus A/B, parainfluenza 1/2/3, rhinovirus, and adenovirus isolated from bronchoalveolar lavage/wash, sputum, or nasal swab. Results The cohort consisted of 263 patients with a mean follow-up time of 612 ± 356 days. The incidence of CARV infection was 27% in patients with normal IgG titers and 23.4% in patients with HGG ( P = .62). No difference in rejection, mortality, or lung function was found between the groups. As expected, patients who ever had a CARV infection had a significantly lower 1-second forced expiratory volume % reference on their most recent spirometry than those who had not had a CARV infection (81.6% vs 86.9%; P = .027). Conclusions Although CARV infection has been shown to affect lung graft function, these data suggests that HGG is not associated with the incidence of CARV infection.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Common Variable Immunodeficiency - diagnosis</subject><subject>Common Variable Immunodeficiency - epidemiology</subject><subject>Common Variable Immunodeficiency - mortality</subject><subject>Community-Acquired Infections - diagnosis</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - mortality</subject><subject>Community-Acquired Infections - virology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Graft Rejection - epidemiology</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Incidence</subject><subject>Kaplan-Meier Estimate</subject><subject>Lung - physiopathology</subject><subject>Lung - virology</subject><subject>Lung Transplantation - adverse effects</subject><subject>Lung Transplantation - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Tract Infections - diagnosis</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - mortality</subject><subject>Respiratory Tract Infections - virology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Texas - epidemiology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Virus Diseases - diagnosis</subject><subject>Virus Diseases - epidemiology</subject><subject>Virus Diseases - mortality</subject><subject>Virus Diseases - virology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhLyCLE5cET-x8cUBaLYVWWgkJClfLccaLl8Te2g5SLvx2HLaVECdOtjXvvDPzeLLsFdACKNRvjkX00oaTdwpxKEoKZQFQUKCPsg20DcvLumSPsw2lHHJgvLrInoVwpOldcvY0uyhZwxto603260prVJE4Ta6XkzvIaZKH0fXzaCxORhJnSfyO5MYqM6BVuCp3bppma-KSb9XdbDwO5DOGk_EyOr-Qb-kypozV2DgbyFZH9GQ_2wO5_dP5KG2Ua-x59kTLMeCL-_My-_rh6nZ3ne8_fbzZbfe54qyKuW562SLtqn6AgWPVI69orweooOs50EYjqBZYo-uurBjvGKu7vm-haTjWsmeX2euzb4J2N2OIYjJB4ZgaQTcHAbysK6h53STp27NUeReCRy1O3kzSLwKoWPmLo_ibv1j5CwCR-Kfkl_d15n5KsYfUB-BJ8P4swDTtT4NeBGVWrkPCqKIYnPm_Ou_-sVHpw4yS4w9cMBzd7G3iKUCEUlDxZd2EdREgmbA0J_sNzkS0zQ</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Noell, B.C</creator><creator>Dawson, K.L</creator><creator>Seethamraju, H</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Effect of Hypogammaglobulinemia on the Incidence of Community-Acquired Respiratory Viral Infections After Lung Transplantation</title><author>Noell, B.C ; Dawson, K.L ; Seethamraju, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-f7ba8e095bd1d4e5be450bfd1519b4107fe1c8137f69253493369bb81774e6ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Common Variable Immunodeficiency - diagnosis</topic><topic>Common Variable Immunodeficiency - epidemiology</topic><topic>Common Variable Immunodeficiency - mortality</topic><topic>Community-Acquired Infections - diagnosis</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - mortality</topic><topic>Community-Acquired Infections - virology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Graft Rejection - epidemiology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Incidence</topic><topic>Kaplan-Meier Estimate</topic><topic>Lung - physiopathology</topic><topic>Lung - virology</topic><topic>Lung Transplantation - adverse effects</topic><topic>Lung Transplantation - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Tract Infections - diagnosis</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - mortality</topic><topic>Respiratory Tract Infections - virology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Texas - epidemiology</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Virus Diseases - diagnosis</topic><topic>Virus Diseases - epidemiology</topic><topic>Virus Diseases - mortality</topic><topic>Virus Diseases - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noell, B.C</creatorcontrib><creatorcontrib>Dawson, K.L</creatorcontrib><creatorcontrib>Seethamraju, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noell, B.C</au><au>Dawson, K.L</au><au>Seethamraju, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Hypogammaglobulinemia on the Incidence of Community-Acquired Respiratory Viral Infections After Lung Transplantation</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>45</volume><issue>6</issue><spage>2371</spage><epage>2374</epage><pages>2371-2374</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>Abstract Background Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipients with HGG are at an increased risk of developing CARV infection. Secondary endpoints included the effect of HGG on lung function, incidence of rejection, and mortality. Methods A retrospective review of all lung transplant recipients from 2008 to 2011 was performed. Patients were stratified as either having HGG after transplantation or having normal IgG titers according to their nadir IgG level. HGG was defined a serum IgG level of <700 mg/dL. CARVs included human metapneumovirus, influenza A/B, respiratory syncytial virus A/B, parainfluenza 1/2/3, rhinovirus, and adenovirus isolated from bronchoalveolar lavage/wash, sputum, or nasal swab. Results The cohort consisted of 263 patients with a mean follow-up time of 612 ± 356 days. The incidence of CARV infection was 27% in patients with normal IgG titers and 23.4% in patients with HGG ( P = .62). No difference in rejection, mortality, or lung function was found between the groups. As expected, patients who ever had a CARV infection had a significantly lower 1-second forced expiratory volume % reference on their most recent spirometry than those who had not had a CARV infection (81.6% vs 86.9%; P = .027). Conclusions Although CARV infection has been shown to affect lung graft function, these data suggests that HGG is not associated with the incidence of CARV infection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23747186</pmid><doi>10.1016/j.transproceed.2012.11.010</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1345 |
| ispartof | Transplantation proceedings, 2013-07, Vol.45 (6), p.2371-2374 |
| issn | 0041-1345 1873-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1426516467 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Biomarkers - blood Common Variable Immunodeficiency - diagnosis Common Variable Immunodeficiency - epidemiology Common Variable Immunodeficiency - mortality Community-Acquired Infections - diagnosis Community-Acquired Infections - epidemiology Community-Acquired Infections - mortality Community-Acquired Infections - virology Female Forced Expiratory Volume Graft Rejection - epidemiology Humans Immunoglobulin G - blood Incidence Kaplan-Meier Estimate Lung - physiopathology Lung - virology Lung Transplantation - adverse effects Lung Transplantation - mortality Male Middle Aged Respiratory Function Tests Respiratory Tract Infections - diagnosis Respiratory Tract Infections - epidemiology Respiratory Tract Infections - mortality Respiratory Tract Infections - virology Retrospective Studies Risk Factors Surgery Texas - epidemiology Time Factors Treatment Outcome Virus Diseases - diagnosis Virus Diseases - epidemiology Virus Diseases - mortality Virus Diseases - virology |
| title | Effect of Hypogammaglobulinemia on the Incidence of Community-Acquired Respiratory Viral Infections After Lung Transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T02%3A31%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Hypogammaglobulinemia%20on%20the%20Incidence%20of%20Community-Acquired%20Respiratory%20Viral%20Infections%20After%20Lung%20Transplantation&rft.jtitle=Transplantation%20proceedings&rft.au=Noell,%20B.C&rft.date=2013-07-01&rft.volume=45&rft.issue=6&rft.spage=2371&rft.epage=2374&rft.pages=2371-2374&rft.issn=0041-1345&rft.eissn=1873-2623&rft_id=info:doi/10.1016/j.transproceed.2012.11.010&rft_dat=%3Cproquest_cross%3E1426516467%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1426516467&rft_id=info:pmid/23747186&rft_els_id=1_s2_0_S0041134512013164&rfr_iscdi=true |