Long-term survival after hepatic and pulmonary resection of colorectal cancer metastases
Background Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified. Methods From 1995 to 2010, 69 patients had curative resection...
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| Veröffentlicht in: | Journal of surgical oncology 2013-09, Vol.108 (4), p.220-224 |
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| creator | Sourrouille, Isabelle Mordant, Pierre Maggiori, Léon Dokmak, Safi Lesèche, Guy Panis, Yves Belghiti, Jacques Castier, Yves |
| description | Background
Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified.
Methods
From 1995 to 2010, 69 patients had curative resection of pulmonary metastases of colorectal cancer; 31 had also hepatic metastases. Pulmonary and hepatic resection occurred in 2 steps (87%). We studied overall and disease‐free survival and prognostic factors.
Results
Primary tumor location was the rectum in 10 cases (32%). Pulmonary metastases were synchronous in 5 (16%) and bilateral in 6 (19%). One patient (3%) died after pulmonary surgery. One (3%) had positive surgical margins for pulmonary metastases. Median overall survival was 44 months (5‐year rate = 36%); median disease‐free survival was 22 months (5‐year rate = 10%). Factors linked to impaired survival were rectal primary tumor (P = 0.04) and bilateral pulmonary metastases (P = 0.02) for overall survival, and pulmonary metastase≥20 mm (P = 0.04) for disease‐free survival.
Conclusion
When associated to adjuvant therapy, complete resection of pulmonary and hepatic metastases of colorectal cancer allows long‐term survival in one third of the patients. J. Surg. Oncol. 2013 108:220–224. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jso.23385 |
| format | Article |
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Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified.
Methods
From 1995 to 2010, 69 patients had curative resection of pulmonary metastases of colorectal cancer; 31 had also hepatic metastases. Pulmonary and hepatic resection occurred in 2 steps (87%). We studied overall and disease‐free survival and prognostic factors.
Results
Primary tumor location was the rectum in 10 cases (32%). Pulmonary metastases were synchronous in 5 (16%) and bilateral in 6 (19%). One patient (3%) died after pulmonary surgery. One (3%) had positive surgical margins for pulmonary metastases. Median overall survival was 44 months (5‐year rate = 36%); median disease‐free survival was 22 months (5‐year rate = 10%). Factors linked to impaired survival were rectal primary tumor (P = 0.04) and bilateral pulmonary metastases (P = 0.02) for overall survival, and pulmonary metastase≥20 mm (P = 0.04) for disease‐free survival.
Conclusion
When associated to adjuvant therapy, complete resection of pulmonary and hepatic metastases of colorectal cancer allows long‐term survival in one third of the patients. J. Surg. Oncol. 2013 108:220–224. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23385</identifier><identifier>PMID: 23893480</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Colorectal cancer ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Hepatectomy - mortality ; Humans ; liver metastasis ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; lung metastasis ; Lung Neoplasms - secondary ; Lung Neoplasms - surgery ; Lymph Node Excision ; Male ; Medical treatment ; Middle Aged ; overall survival ; Pneumonectomy - mortality ; Prognosis ; Retrospective Studies</subject><ispartof>Journal of surgical oncology, 2013-09, Vol.108 (4), p.220-224</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4575-bef2be30a73ab2527829d694b82ce796ba07237612362e920751d463fe8429ca3</citedby><cites>FETCH-LOGICAL-c4575-bef2be30a73ab2527829d694b82ce796ba07237612362e920751d463fe8429ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.23385$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.23385$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23893480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sourrouille, Isabelle</creatorcontrib><creatorcontrib>Mordant, Pierre</creatorcontrib><creatorcontrib>Maggiori, Léon</creatorcontrib><creatorcontrib>Dokmak, Safi</creatorcontrib><creatorcontrib>Lesèche, Guy</creatorcontrib><creatorcontrib>Panis, Yves</creatorcontrib><creatorcontrib>Belghiti, Jacques</creatorcontrib><creatorcontrib>Castier, Yves</creatorcontrib><title>Long-term survival after hepatic and pulmonary resection of colorectal cancer metastases</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified.
Methods
From 1995 to 2010, 69 patients had curative resection of pulmonary metastases of colorectal cancer; 31 had also hepatic metastases. Pulmonary and hepatic resection occurred in 2 steps (87%). We studied overall and disease‐free survival and prognostic factors.
Results
Primary tumor location was the rectum in 10 cases (32%). Pulmonary metastases were synchronous in 5 (16%) and bilateral in 6 (19%). One patient (3%) died after pulmonary surgery. One (3%) had positive surgical margins for pulmonary metastases. Median overall survival was 44 months (5‐year rate = 36%); median disease‐free survival was 22 months (5‐year rate = 10%). Factors linked to impaired survival were rectal primary tumor (P = 0.04) and bilateral pulmonary metastases (P = 0.02) for overall survival, and pulmonary metastase≥20 mm (P = 0.04) for disease‐free survival.
Conclusion
When associated to adjuvant therapy, complete resection of pulmonary and hepatic metastases of colorectal cancer allows long‐term survival in one third of the patients. J. Surg. Oncol. 2013 108:220–224. © 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Hepatectomy - mortality</subject><subject>Humans</subject><subject>liver metastasis</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>lung metastasis</subject><subject>Lung Neoplasms - secondary</subject><subject>Lung Neoplasms - surgery</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>overall survival</subject><subject>Pneumonectomy - mortality</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtP3DAUhS1UBMPAgj-AInUDi8CNn_GygpaHRiDUVrCzHM9Nm2kSD3ZCO_8elwEWSEiWrCN_59zrQ8h-AccFAD1ZRH9MGSvFBpkUoGWuQZefyCS90ZwrDdtkJ8YFAGgt-RbZpqzUjJcwIfcz3__KBwxdFsfw2DzaNrN10tlvXNqhcZnt59lybDvf27DKAkZ0Q-P7zNeZ860PSSaPs71Lpg4HG9PBuEs2a9tG3Hu5p-Tnt68_Ti_y2c355emXWe64UCKvsKYVMrCK2YoKqkqq51LzqqQOlZaVBUWZkgVlkqKmoEQx55LVWHKqnWVTcrjOXQb_MGIcTNdEh21re_RjNAWnUoAuVJnQz-_QhR9Dn7ZLFGcC0niVqKM15YKPMWBtlqHp0t9NAeZ_3SbVbZ7rTuzBS-JYdTh_I1_7TcDJGvjbtLj6OMlcfb95jczXjiYO-O_NYcMfIxVTwtxdnxt1L0Gcwa25Zk8zUJe4</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Sourrouille, Isabelle</creator><creator>Mordant, Pierre</creator><creator>Maggiori, Léon</creator><creator>Dokmak, Safi</creator><creator>Lesèche, Guy</creator><creator>Panis, Yves</creator><creator>Belghiti, Jacques</creator><creator>Castier, Yves</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Long-term survival after hepatic and pulmonary resection of colorectal cancer metastases</title><author>Sourrouille, Isabelle ; Mordant, Pierre ; Maggiori, Léon ; Dokmak, Safi ; Lesèche, Guy ; Panis, Yves ; Belghiti, Jacques ; Castier, Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4575-bef2be30a73ab2527829d694b82ce796ba07237612362e920751d463fe8429ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Hepatectomy - mortality</topic><topic>Humans</topic><topic>liver metastasis</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>lung metastasis</topic><topic>Lung Neoplasms - secondary</topic><topic>Lung Neoplasms - surgery</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>overall survival</topic><topic>Pneumonectomy - mortality</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sourrouille, Isabelle</creatorcontrib><creatorcontrib>Mordant, Pierre</creatorcontrib><creatorcontrib>Maggiori, Léon</creatorcontrib><creatorcontrib>Dokmak, Safi</creatorcontrib><creatorcontrib>Lesèche, Guy</creatorcontrib><creatorcontrib>Panis, Yves</creatorcontrib><creatorcontrib>Belghiti, Jacques</creatorcontrib><creatorcontrib>Castier, Yves</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sourrouille, Isabelle</au><au>Mordant, Pierre</au><au>Maggiori, Léon</au><au>Dokmak, Safi</au><au>Lesèche, Guy</au><au>Panis, Yves</au><au>Belghiti, Jacques</au><au>Castier, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term survival after hepatic and pulmonary resection of colorectal cancer metastases</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>108</volume><issue>4</issue><spage>220</spage><epage>224</epage><pages>220-224</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background
Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified.
Methods
From 1995 to 2010, 69 patients had curative resection of pulmonary metastases of colorectal cancer; 31 had also hepatic metastases. Pulmonary and hepatic resection occurred in 2 steps (87%). We studied overall and disease‐free survival and prognostic factors.
Results
Primary tumor location was the rectum in 10 cases (32%). Pulmonary metastases were synchronous in 5 (16%) and bilateral in 6 (19%). One patient (3%) died after pulmonary surgery. One (3%) had positive surgical margins for pulmonary metastases. Median overall survival was 44 months (5‐year rate = 36%); median disease‐free survival was 22 months (5‐year rate = 10%). Factors linked to impaired survival were rectal primary tumor (P = 0.04) and bilateral pulmonary metastases (P = 0.02) for overall survival, and pulmonary metastase≥20 mm (P = 0.04) for disease‐free survival.
Conclusion
When associated to adjuvant therapy, complete resection of pulmonary and hepatic metastases of colorectal cancer allows long‐term survival in one third of the patients. J. Surg. Oncol. 2013 108:220–224. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23893480</pmid><doi>10.1002/jso.23385</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Colorectal cancer Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Hepatectomy - mortality Humans liver metastasis Liver Neoplasms - secondary Liver Neoplasms - surgery lung metastasis Lung Neoplasms - secondary Lung Neoplasms - surgery Lymph Node Excision Male Medical treatment Middle Aged overall survival Pneumonectomy - mortality Prognosis Retrospective Studies |
| title | Long-term survival after hepatic and pulmonary resection of colorectal cancer metastases |
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