Acute tolerance development to the diuretic effect of furosemide in the rat

Furosemide was given to rats as five different i.v. bolus doses (2.5–100mg kg−1), or as an i.v. infusion to a steady‐state concentration in plasma of 14μg ml−1. The urinary furosemide excretion rate (ΔAe/Δt) and the diuretic effect (volume of urine) were measured. A parallel shift in the excretion—r...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1985-01, Vol.6 (1), p.9-21
Hauptverfasser:	Hammarlund, Margareta, Paalzow, Lennart K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute tolerance development Animals Biological and medical sciences Diuretics Drug Tolerance Efficiency Furosemide Furosemide - administration & dosage Furosemide - metabolism Furosemide - pharmacology Infusions, Parenteral Injections, Intravenous Kinetics Male Medical sciences Pharmacodynamics Pharmacokinetics Pharmacology. Drug treatments Rats Rats, Inbred Strains Urinary system
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