Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-β signalling pathway

Pancreatic cancer treatment is limited and effective drugs are needed. We investigated cucurmosin (CUS)-induced apoptosis in cystic fibrosis pancreatic adenocarcinoma cells (CFPAC-1) and a possible mechanism of action to evaluate the clinical application potential of this new Type I ribosome-inactiv...

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Veröffentlicht in:	Pharmacological reports 2013, Vol.65 (3), p.682-688
Hauptverfasser:	Xie, Jieming, Wang, Congfei, Zhang, Baoming, Yang, Aiqin, Yin, Qiang, Huang, Heguang, Chen, Minghuang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism apoptosis Apoptosis - drug effects Apoptosis - genetics Caspase 3 - genetics Caspase 3 - metabolism Caspase 9 - genetics Caspase 9 - metabolism Cell Line, Tumor Cell Proliferation - drug effects cucurmosin Cystic Fibrosis - genetics Cystic Fibrosis - metabolism Down-Regulation - drug effects Down-Regulation - genetics Drug Safety and Pharmacovigilance Humans pancreatic carcinoma Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism PDGFR Pharmacotherapy Pharmacy Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt/mTOR Plant Proteins - pharmacology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptor, Platelet-Derived Growth Factor beta - genetics Receptor, Platelet-Derived Growth Factor beta - metabolism RNA, Messenger - genetics Signal Transduction - drug effects Signal Transduction - genetics TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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