Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib

Low brain accumulation of anticancer drugs due to efflux transporters may limit chemotherapeutic efficacy, necessitating a better understanding of the underlying mechanisms. P-glycoprotein (Abcb1a/1b) and breast cancer resistance protein (Abcg2) combination knockout mice often display disproportiona...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2013-09, Vol.346 (3), p.486-494
Hauptverfasser:	Tang, Seng Chuan, de Vries, Niels, Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve ATP Binding Cassette Transporter, Sub-Family B - genetics ATP Binding Cassette Transporter, Sub-Family B - physiology ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - physiology Brain - metabolism Dasatinib DNA, Complementary - biosynthesis DNA, Complementary - genetics Female Gene Dosage Half-Life Indoles - pharmacokinetics Male Maternal-Fetal Exchange Mice Mice, Knockout Niacinamide - analogs & derivatives Niacinamide - pharmacokinetics Phenylurea Compounds - pharmacokinetics Pregnancy Protein Kinase Inhibitors - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Pyrimidines - pharmacokinetics Pyrroles - pharmacokinetics Real-Time Polymerase Chain Reaction RNA - biosynthesis RNA - genetics Sex Characteristics Thiazoles - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!