Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches
It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase activity as well as enhances the production of reactive oxygen species, thus resulting in diminished nitric oxide bioavailability and the consequent pro-atherogenetic alterations. Important biomarkers of the...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2013-08, Vol.62 (8), p.667-676 |
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| container_title | Journal of the American College of Cardiology |
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| creator | Tousoulis, Dimitris Papageorgiou, Nikolaos Androulakis, Emmanuel Siasos, Gerasimos Latsios, George Tentolouris, Konstantinos Stefanadis, Christodoulos |
| description | It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase activity as well as enhances the production of reactive oxygen species, thus resulting in diminished nitric oxide bioavailability and the consequent pro-atherogenetic alterations. Important biomarkers of the vasculature are related to endothelial dysfunction, to inflammatory and coagulation processes, and to oxidative stress in DM. Several therapeutic strategies might exert favorable effects on the vasculature of diabetic patients, such as insulin analogues, antihypertensive agents, statins, and hypoglycemic agents, whereas in spite of the prominent role of oxidative stress in diabetes, antioxidant therapy remains controversial. The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients. |
| doi_str_mv | 10.1016/j.jacc.2013.03.089 |
| format | Article |
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Important biomarkers of the vasculature are related to endothelial dysfunction, to inflammatory and coagulation processes, and to oxidative stress in DM. Several therapeutic strategies might exert favorable effects on the vasculature of diabetic patients, such as insulin analogues, antihypertensive agents, statins, and hypoglycemic agents, whereas in spite of the prominent role of oxidative stress in diabetes, antioxidant therapy remains controversial. The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients.</description><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2013.03.089</identifier><identifier>PMID: 23948511</identifier><language>eng</language><publisher>United States</publisher><subject>Antioxidants - therapeutic use ; Biomarkers - blood ; C-Reactive Protein - analysis ; Cytokines - blood ; Diabetic Angiopathies - blood ; Diabetic Angiopathies - physiopathology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hyperglycemia - physiopathology ; Insulin Resistance - physiology ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; RNA, Messenger - physiology ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>Journal of the American College of Cardiology, 2013-08, Vol.62 (8), p.667-676</ispartof><rights>Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23948511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tousoulis, Dimitris</creatorcontrib><creatorcontrib>Papageorgiou, Nikolaos</creatorcontrib><creatorcontrib>Androulakis, Emmanuel</creatorcontrib><creatorcontrib>Siasos, Gerasimos</creatorcontrib><creatorcontrib>Latsios, George</creatorcontrib><creatorcontrib>Tentolouris, Konstantinos</creatorcontrib><creatorcontrib>Stefanadis, Christodoulos</creatorcontrib><title>Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase activity as well as enhances the production of reactive oxygen species, thus resulting in diminished nitric oxide bioavailability and the consequent pro-atherogenetic alterations. Important biomarkers of the vasculature are related to endothelial dysfunction, to inflammatory and coagulation processes, and to oxidative stress in DM. Several therapeutic strategies might exert favorable effects on the vasculature of diabetic patients, such as insulin analogues, antihypertensive agents, statins, and hypoglycemic agents, whereas in spite of the prominent role of oxidative stress in diabetes, antioxidant therapy remains controversial. The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients.</description><subject>Antioxidants - therapeutic use</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cytokines - blood</subject><subject>Diabetic Angiopathies - blood</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Hyperglycemia - physiopathology</subject><subject>Insulin Resistance - physiology</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>RNA, Messenger - physiology</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UE1Lw0AUXASxtfoHPMgevSS-l92kW29SP6HgRc_hZfNqt-bL3Y3gvzdihYE5zDDDjBAXCCkCFtf7dE_WphmgSmGCWR2JOea5SVS-Ws7EaQh7ACgMrk7ELFMrbXLEuXB3jiqOHGTLTePiGBIKobeOItfyi4IdG_LStQM533IXb2TXf3EjrfO_UnTdu6xc35L_YB8kdbWMO_Y08BidlTQMvie743AmjrfUBD4_8EK8Pdy_rp-Szcvj8_p2kwwZYkw4A1CVxkJnmYUtFRo0aqQCKjYKLBiroTbLLedWK7RkGDRpVZFFRLBqIa7-cqfiz5FDLFsX7DSOOu7HUKLOCsAM82KyXh6sY9VyXQ7eTTu-y_971A8-Q2gq</recordid><startdate>20130820</startdate><enddate>20130820</enddate><creator>Tousoulis, Dimitris</creator><creator>Papageorgiou, Nikolaos</creator><creator>Androulakis, Emmanuel</creator><creator>Siasos, Gerasimos</creator><creator>Latsios, George</creator><creator>Tentolouris, Konstantinos</creator><creator>Stefanadis, Christodoulos</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130820</creationdate><title>Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches</title><author>Tousoulis, Dimitris ; Papageorgiou, Nikolaos ; Androulakis, Emmanuel ; Siasos, Gerasimos ; Latsios, George ; Tentolouris, Konstantinos ; Stefanadis, Christodoulos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-e2003b416422c0fa6404141a60be830c08c40d87fe5c431ca8e04a43bac1110c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antioxidants - therapeutic use</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cytokines - blood</topic><topic>Diabetic Angiopathies - blood</topic><topic>Diabetic Angiopathies - physiopathology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Hyperglycemia - physiopathology</topic><topic>Insulin Resistance - physiology</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>RNA, Messenger - physiology</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tousoulis, Dimitris</creatorcontrib><creatorcontrib>Papageorgiou, Nikolaos</creatorcontrib><creatorcontrib>Androulakis, Emmanuel</creatorcontrib><creatorcontrib>Siasos, Gerasimos</creatorcontrib><creatorcontrib>Latsios, George</creatorcontrib><creatorcontrib>Tentolouris, Konstantinos</creatorcontrib><creatorcontrib>Stefanadis, Christodoulos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tousoulis, Dimitris</au><au>Papageorgiou, Nikolaos</au><au>Androulakis, Emmanuel</au><au>Siasos, Gerasimos</au><au>Latsios, George</au><au>Tentolouris, Konstantinos</au><au>Stefanadis, Christodoulos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2013-08-20</date><risdate>2013</risdate><volume>62</volume><issue>8</issue><spage>667</spage><epage>676</epage><pages>667-676</pages><eissn>1558-3597</eissn><abstract>It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase activity as well as enhances the production of reactive oxygen species, thus resulting in diminished nitric oxide bioavailability and the consequent pro-atherogenetic alterations. Important biomarkers of the vasculature are related to endothelial dysfunction, to inflammatory and coagulation processes, and to oxidative stress in DM. Several therapeutic strategies might exert favorable effects on the vasculature of diabetic patients, such as insulin analogues, antihypertensive agents, statins, and hypoglycemic agents, whereas in spite of the prominent role of oxidative stress in diabetes, antioxidant therapy remains controversial. The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients.</abstract><cop>United States</cop><pmid>23948511</pmid><doi>10.1016/j.jacc.2013.03.089</doi><tpages>10</tpages></addata></record> |
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| identifier | EISSN: 1558-3597 |
| ispartof | Journal of the American College of Cardiology, 2013-08, Vol.62 (8), p.667-676 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antioxidants - therapeutic use Biomarkers - blood C-Reactive Protein - analysis Cytokines - blood Diabetic Angiopathies - blood Diabetic Angiopathies - physiopathology Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperglycemia - physiopathology Insulin Resistance - physiology Oxidative Stress - drug effects Oxidative Stress - physiology RNA, Messenger - physiology Tumor Necrosis Factor-alpha - physiology |
| title | Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches |
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