Donor Assists Acceptor Binding and Catalysis of Human α1,6-Fucosyltransferase

α1,6-Core-fucosyltransferase (FUT8) is a vital enzyme in mammalian physiological and pathophysiological processes such as tumorigenesis and progress of, among others, non-small cell lung cancer and colon carcinoma. It was also shown that therapeutic antibodies have a dramatically higher efficacy if...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS chemical biology 2013-08, Vol.8 (8), p.1830-1840
Hauptverfasser:	Kötzler, Miriam P, Blank, Simon, Bantleon, Frank I, Wienke, Martin, Spillner, Edzard, Meyer, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Carbohydrate Sequence Catalysis Fucosyltransferases - chemistry Fucosyltransferases - metabolism Humans Models, Molecular Molecular Dynamics Simulation Peptides - chemistry Peptides - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!